Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left‐right asymmetry

Abstract

Interactions between magnetic fields (MFs) and living cells may stimulate a large variety of cellular responses to a MF, while the underlying intracellular mechanisms still remain a great puzzle. On a fundamental level, the MF — cell interaction is affected by the two broken symmetries: (a) left‐right (LR) asymmetry of the MF and (b) chirality of DNA molecules carrying electric charges and subjected to the Lorentz force when moving in a MF. Here we report on the chirality‐driven effect of static magnetic fields (SMFs) on DNA synthesis. This newly discovered effect reveals how the interplay between two fundamental features of symmetry in living and inanimate nature—DNA chirality and the inherent features of MFs to distinguish the left and right—manifests itself in different DNA synthesis rates in the upward and downward SMFs, consequently resulting in unequal cell proliferation for the two directions of the field. The interplay between DNA chirality and MF LR asymmetry will provide fundamental knowledge for many MF‐induced biological phenotypes.

An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth

“…Moreover, other than magnetic field intensity, there are multiple evidences showing that the magnetic field direction is also a key factor. More specifically, experiments show that the upward direction and downward direction SMFs could produce differential effects on cells, plants and mice [ 6 , [12] , [13] , [14] , [15] ].…”

Innate Immune Regulation Under Magnetic Fields With Possible Mechanisms and Therapeutic Applications

“…Interestingly, Yang et al recently published very important results regarding the chiralitydriven effect of static MFs on DNA synthesis. This newly discovered effect may provide fundamental knowledge for many MF-induced biological effects (46). An SMF of 27 T was reported to change the orientation and morphology of mitotic spindles in human cells, which suggests that the magnetic torque acts on both microtubules and chromosomes (42).…”

Comparative review on left-handed Z-DNA

“…Amid DNA phosphate group electrostatic repulsion reduce by the cationic backbone of the copolymer and the transition is a result of these 2 factors. The most plausible Z form created negative supercoiling, utilizing B-DNA occurs during several metabolisms like Transcription and replication processes [28]. For reducing the transition stress, unusual such DNA as Z-DNA is formed [6,29].…”

“…Lee et al (1992) used "Magnetic-tweezers" and FRET combinedly to examine at molecule level of negative supercoiling [30]. Mag-netic tweezers are a very useful technique for investigating wind/unwinding procedure of twisted DNA through precisely controlling infinite tension [28,31]. Therefore, B-Z change can be active by tiny negative super helicity and approximately one Pico Newton Tension.…”