An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth

Yang, Xingxing; Chen, Song; Zhang, Lei; Wang, Junjun; Yu, Xin; Yu, Biao; Zablotskii, V.; Zhang, Xin

doi:10.1016/j.tranon.2021.101103

Cited by 31 publications

(35 citation statements)

References 43 publications

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“…Moreover, Csillag et al placed human lung cancer cells (A549) in 389 mT SMF for 30 minutes and observed an obvious decrease in ROS levels [ 34 ]. On the contrary, our previous study showed that 9.4 T SMF could significantly increase A549 cellular ROS levels [ 20 ]. It is obvious that SMFs with different parameters could generate various effects on cancer cells.…”

Section: Discussionmentioning

confidence: 80%

“…To further examine the effects of moderate SMFs on ovarian cancer cells, we used a superconducting magnet that has a cell culture compatible system ( Figure 4(a) ) [ 20 ]. We placed the cells at the upper part of the magnet where the intensity of SMF is ~0.5 T. Similar to the permanent magnet, this 0.5 T SMF also significantly decreased HO8910 and SKOV3 ovarian cancer cell invasion ( Figure 4(b) ) and migration ( Figure 4(c) ) in Transwell assays.…”

Section: Resultsmentioning

confidence: 99%

“…It is similar that ROS levels are increased by 8.5 T SMFs in human-hamster hybrid A(L) cells, mitochondria-deficient rho(0) A(L) cells, and double-strand break repair-deficient cells XRS-5, as well as mouse embryonic stem (ES) cells and derived cells [ 32 ]. Meanwhile, our previous study showed that the ROS levels were obviously increased by 9.4 T SMF, causing cell cycle arrest in human lung cancer cells A549 [ 20 ]. However, multiple studies demonstrate SMFs could reduce cellular ROS levels.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, SMFs of ~0.5 T with gradient were provided by superconducting magnet or permanent magnets. A superconducting magnet (Western Superconducting, Xi'an, China) with proper temperature, gas, and humidity control [ 20 ] was operated at 9.4 T at the maximum intensity at the center. Our samples were placed in the upper part of the superconducting magnet, where the magnetic field is approximately 0.5 T. Besides, N38 neodymium permanent magnets (NdFeB) were also used to provide SMFs of ~0.5 T (Sans, Nanjing, China).…”

Section: Methodsmentioning

confidence: 99%

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Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS‐Mediated Oxidative Stress

Chen

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Metastasis is the leading cause of cancer patient death, which is closely correlated with reactive oxygen species (ROS) levels. It is well known that the effects of ROS on tumors are diverse, depending on ROS concentration and cell type. We found that ovarian cancer cells have significantly lower levels of ROS than normal ovarian cells. Moreover, increased ROS levels in ovarian cancer cells can substantially inhibit their migration and invasion ability. Furthermore, the results show that moderate static magnetic field (SMF) can inhibit ovarian cancer cell migration, invasion, and stemness in a ROS-dependent manner. RNA sequencing results confirm that SMFs increased the oxidative stress level and reduced the stemness of ovarian cancer cells. Consistently, the expressions of stemness-related genes were significantly decreased, including hyaluronan receptor (CD44), SRY-box transcription factor 2 (Sox2), and cell myc proto-oncogene protein (C-myc). Furthermore, moderate SMFs provided by a superconducting magnet and permanent magnet have good biosafety and can both inhibit ovarian cancer metastasis in mice. Therefore, our study demonstrates the effects of SMFs on oxidative stress and metastasis in the ovarian cancer cells, which reveals the potential of applying SMF as a physical method in cancer therapy in the future.

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Section: Discussionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS‐Mediated Oxidative Stress

Chen

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…A recent study 24 showed a different impact of opposite polarity magnetic elds on hematological parameters of spontaneously hypertensive rats. Another recent study 25 found that long-term exposure (88 h) of a MF of 9.4 T (Tesla) strength (planned for use in magnetic resonance imaging) signi cantly inhibited tumor growth (up to 41%) in mice with lung cancer. This effect was observed only with exposure to the magnetic north pole.…”

Section: Introductionmentioning

confidence: 99%

Effect of Magnetic Fields on UV Absorption and Evaporation of Water

Shalatonin¹,

Pollack²

2021

Preprint

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We investigated the effects of unipolar magnetic fields (N or S polarity) on the physical properties of deionized water. Long-term experiments revealed significant pole-dependent changes in water absorption in the UV range (180 – 350 nm). In the case of water in open vessels, the order of absorption values was C-N-S. That is, control (C) water absorbed the most, N-pole-influenced water absorbed less, and S pole the least. The differences in absorption between N and S waters were substantial. In the case of closed vessels, the differences in absorption spectra substantially diminished, and the arrangement of the absorption values became C-S-N (highest to lowest). A correlation between UV absorption values and evaporation rates was also found. The relative order of evaporation rates, C-N-S (highest to lowest), was the same as the order of the absorption values, also C-N-S. The differences in UV absorption spectra of the N- and S-treated waters persisted for several months after removing the magnets. Hence, the effects of magnetic fields were long term. The interaction of magnetic fields with water is of interest not only from a physical sciences perspective, but also in the context of the significant applications in medicine and biology.

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Triggering gel‐sol transition by weak magnetic field

et al. 2023

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The self‐assembly of small and always chiral molecules into fiber‐like structures is a mysterious process, as the physics underlying such self‐assembly is unclear. The energy necessary for this process exceeds the one provided by common dispersion interactions and hydrogen bonding. The recent results obtained by the scientific group of Prof. Naaman from the Weizmann Institute of Science fed light on the nature of forces providing for the self‐assembly of chiral molecules and attributed these forces to spin‐exchange interactions. Therefore, the self‐assembly of chiral molecules should be magneto‐sensitive. We found such sensitivity in solutions of trifluoroacetylated ‐amino alcohols, and the process was inhibited by the magnetic field when fibers grew on the surface of the substrate. On the contrary, in bulk, the self‐assembly was enhanced by the magnetic field and led to the formation of a dense gel, while no gelation was observed in the absence of the external magnetic field. The latter observations are the theme of this short report, aimed to declare the effect itself but not pretend to describe it in full.

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An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth

Cited by 31 publications

References 43 publications

Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS‐Mediated Oxidative Stress

Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS‐Mediated Oxidative Stress

Effect of Magnetic Fields on UV Absorption and Evaporation of Water

Triggering gel‐sol transition by weak magnetic field

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