Effect of Stachytarpheta jamaicensis L. (Vahl.) on Wistar Rats: Serum Biochemistry and Ultrasonography

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

“…There are few toxicity studies being conducted on S. jamaicensis . Study from Idu et al [45] documented that rats were administered with 25, 50, and 75 g of powdered S. jamaicensis leaves showing no significant alteration in the normal serum biochemistry when compared with control. Moreover, ultrasound picture of heart, liver, kidney, and spleen also showed no significant difference from control [45].…”

“…Study from Idu et al [45] documented that rats were administered with 25, 50, and 75 g of powdered S. jamaicensis leaves showing no significant alteration in the normal serum biochemistry when compared with control. Moreover, ultrasound picture of heart, liver, kidney, and spleen also showed no significant difference from control [45]. However, Ataman et al [46] reported that rats were fed with the same dose and concentration as in Idu et al [45] showed slight variation on the physical signs/body appearance of the animals and mild histopathologic lesions such as congestion, fatty changes, and necrosis were found in certain tissues, such as liver, blood vessels, kidney, lung, and testis.…”

“…Moreover, ultrasound picture of heart, liver, kidney, and spleen also showed no significant difference from control [45]. However, Ataman et al [46] reported that rats were fed with the same dose and concentration as in Idu et al [45] showed slight variation on the physical signs/body appearance of the animals and mild histopathologic lesions such as congestion, fatty changes, and necrosis were found in certain tissues, such as liver, blood vessels, kidney, lung, and testis. On the other hand, the brain, eyes, small and large intestines, and heart tissues were essentially normal.…”