Hypotensive Effects and Acute Toxicity Property of Methanol Extract of Baissea axillaris Hau. Leaf on Animal Models

Idu, MacDonald; Timothy, O.; Omogbai, Eric K. I.; ., F. Amaechina

doi:10.3923/jbs.2008.675.678

Cited by 4 publications

(2 citation statements)

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“…It has been traditionally used over centuries as a folklore remedy for a wide range of ailments and as an herbal supplement for health improvement (Jarukamjorn & Nemoto, 2008; Mishra, Sangwan, & Sangwan, 2007). The use of plants and plant extracts as therapeutics to treat various diseases has been explored over the years and is still been explored (Idu, Timothy, Omogbai, & Amaechina, 2008). A. paniculata leaves are edible, occasionally mixed with vegetables (Medhi, Sarma, & Borthakur, 2014; Panda, 2015), and has been known to possess a broad range of pharmacological effects such as anti‐inflammatory, hepatoprotective, psychopharmacological, and radical scavenging activities (Akbar, 2011; Mandal, Dhara, & Maiti, 2001; Parixit, Bharath, Rajarajeshwari, & Ganapaty, 2012; Sivakumar & Rajeshkumar, 2015).…”

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confidence: 99%

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

et al. 2020

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The brain plays a major role in the central nervous system (CNS) and an important organ of the body that controls the functions of all other organs with the aid of neurons through signal transmission, whereas, in neurodegeneration, the functions of these neurons are impaired or altered (Ortman, Velkoff, & Hogan, 2014). Neurodegeneration is a process that refers to any pathology that mainly affects the neurons gradually. This condition alters the structure and function of neurons which leads to increased neuronal death, poor decision making, loss

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Section: Introductionmentioning

confidence: 99%

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

et al. 2020

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“…The use of plants, plant extracts or plant-derived chemicals to treat diseases is a therapeutic modality that has been explored for centuries. Over 40,000 species of tropical flowering plants are known to possess medicinal properties [1] and are currently in use for various medical conditions. Majority of Africans patronize herbal or traditional medicine for their health needs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Median Lethal Dose and Subchronic Oral Toxicity Assessment of Ethanolic Leaf Extract of Phyllanthus amarus

Adolor

Onyesom

Opajobi

et al. 2019

JPRI

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Aims: To determine the median lethal dose (LD50) of crude ethanolic leaf extract of Phyllanthus amarus and evaluate its sub-chronic oral toxicity in experimental mice (BALB/C strain). Study Design: One-factor, one-control, one-test group experimental design. Place and Duration of Study: Department of Medical Biochemistry, Delta State University, Abraka, Nigeria, between December, 2014 and November, 2015. Methodology: Crude ethanolic leaf extract of P. amarus was prepared as previously described and twenty (20) Swiss albino mice (BALB/C strain) were randomly and equally divided into two (2) groups and administered 2000 mg/kg body weight (Group A) and 5000 mg/kg body weight (Group B) of the prepared extract as single oral dose in line with the limit dose method of determining LD50. For the sub-chronic oral toxicity study, ten (10) mice were assigned into control (n=5) and experimental (n=5). The control animals were given placebo-normal saline, but the experimental mice were administered with nocebo – 300 mg/kg body weight of P. amarus crude ethanolic extract for twenty one (21) days. Thereafter, the animals in each group were sacrificed and then, serum and liver homogenate were obtained for the assay of total antioxidant capacity (TAC) and oxidative damage (Malondialdehyde-MDA) Using documented methods. Liver tissue was also processed for histopathological examination using H&E stain. Results: Data showed LD50 of the extract to be greater than 5000 mg/kg. Assessment of the herb’s sub-chronic oral toxicity indicates that the leaf extract significantly (P=.03) enhanced total antioxidant capacity (TAC) in both serum (Control: TAC = 0.10±0.03 mM, Experimental: TAC = 0.33±0.05 mM) and liver (Control: TAC = 0.12±0.09 mM, Experimental: TAC = 0.34±0.06 mM) but reduced (P = .01) the biomarker for liver tissue damage (Control: MDA = 41.89±3.36 µM, Experimental: MDA = 4.67±4.04 µM). In addition, hepatic cells were invigorated by P. amarus treatment as suggested by the histopathological features. Conclusion: Collectively, P. amarus crude ethanolic leaf extract possesses high degree of tolerance and hepatic tonic potential with no identifiable toxic or side effects.

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Toxicopathological evaluation of a 28-day repeated dose administration ofZea maysL. (Poaceae),Stigma maydisaqueous extract on key metabolic markers of Wistar rats

Sabiu

O’Neill

Ashafa

2017

Transactions of the Royal Society of South Africa

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Hypotensive Effects and Acute Toxicity Property of Methanol Extract of Baissea axillaris Hau. Leaf on Animal Models

Cited by 4 publications

References 16 publications

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine‐induced amnesic rats

Evaluation of Median Lethal Dose and Subchronic Oral Toxicity Assessment of Ethanolic Leaf Extract of Phyllanthus amarus

Toxicopathological evaluation of a 28-day repeated dose administration ofZea maysL. (Poaceae),Stigma maydisaqueous extract on key metabolic markers of Wistar rats

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