Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice

Premkumar, Kumpati; Arjunan, Pachiappan; Abraham, Suresh K.; Santhiya, S.; Gopinath, P. M.; Ramesh, A.

doi:10.1016/s0367-326x(01)00340-9

Cited by 87 publications

(58 citation statements)

References 15 publications

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“…This finding suggests that CSE may be successful in quenching free radicals, thus inhibiting LPO and protecting against membrane damage from oxidative damage in mice. Our results are consistent with those of some studies indicating CP intoxication, significant depletion of the GSH level, and significant increase in the MDA, BUN, and Cr levels, thus corroborating the state of oxidative stress (20,(45)(46)(47).…”

Section: Discussionsupporting

confidence: 93%

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Kalantar

Goudarzi

Khodayar

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Cyclophosphamide (CP) is one of the most popular alkylating anticancer drugs despite its toxic side effects, including nephrotoxicity, hematotoxicity, mutagenicity, and immunotoxicity. Capparis spinosa is a multipurpose plant that contains a number of chemically active and diverse secondary metabolites, particularly flavonoids. Rutin and quercetin are two major flavonoids in the caper plant. Objectives: This study was undertaken to investigate the protective effect of Capparis spinosa L. extract on nephrotoxicity induced by cyclophosphamide in mice. Methods: In this experimental study, 40 male Swiss albino mice (20 -25 g) were randomly divided into five groups with each group consisting of eight mice. Mice were pretreated with C. spinosa extract (CSE) orally in doses of 100, 200 and 400 mg/kg for five consecutive days, and CP (200 mg/kg, ip) was administrated on the fifth day 1 hour after the last dose of extract. The animals were sacrificed on the sixth day. Blood samples were collected to determine the serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The malondialdehyde (MDA) and glutathione (GSH) levels were assayed in kidney tissue. The right kidney was maintained in 10% formalin for hematoxylin and eosin staining and histological examination. Results: Different plant parts (fruit, leaves, and petals) were examined for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl assay, and leaf extract was used to determine nephroprotective effects. Results showed a significant increase in the levels of MDA, Cr, and BUN and a reduction of GSH by CP administration. Pre-treatment with CSE decreased the levels of MDA, Cr, and BUN. GSH increased in all doses, but the most significant alteration was observed in the doses of 200 and 400 mg/kg (P < 0.05). The nephroprotective effect of the CSE was confirmed by the histological examination of the kidneys. Conclusions: Our results indicate that CSE ameliorates biochemical indices and oxidative stress parameters against CP-induced nephrotoxicity.

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Section: Discussionsupporting

confidence: 93%

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Kalantar

Goudarzi

Khodayar

et al. 2016

Jundishapur J Nat Pharm Prod

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“…It also normalized the levels of both enzymatic and non-enzymatic antioxidants (GSH, SOD and CAT) in liver. This Spirulina-induced oxidative stress protection may be well correlated with previous studies, where Spirulina has been shown to restored the level of antioxidant enzymes and oxidative stress markers against cyclophosphamide and mitomycin C [25] and cisplatin and urethane [11] in mice. The protective effect of Spirulina against Cd-induced oxidative stress in this study could also be attributed to its antioxidant and chelating effects.…”

Section: Discussionsupporting

confidence: 89%

Spirulina protects against cadmium-induced hepatotoxicity in rats

Amin¹,

Hamza²,

Daoud³

et al. 2006

American J. of Pharmacology and Toxicology

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Cadmium (Cd) is an environmental and industrial cumulative pollutant that most affects many organs specially the liver. The protective effect of Spirulina, filamentous blue green algae, on Cd -induced oxidative stress and hepatotoxicity was evaluated in male rats. Oral administration of water extract of Spirulina for seven days followed by an acute toxic dose of Cd (3.5 mg kg b.wt. 1 ), reduced the hepatotoxicity and attenuated the Cd-induced oxidative stress. Spirulina treatment showed marked reduction in serum aminotrasferase activities and elevation in lipid peroxidation and recovery of the endogenous levels of antioxidants following Cd-intoxication. The Cd-induced hepatic histopathological changes were also minimized with the tested extract. These results suggest that Spirulina algae might play a role in reducing the toxic effect of Cd and its antioxidant properties seems to mediate such a protective effect.

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“…Pretreatment with LOE restored the MDA level, suggesting that LOE might be successful in quenching free radicals, thus inhibiting LPO and protecting against membrane damage from oxidative damage in mice. Our results were parallel to some studies which indicated, the after CP intoxication, significant depletion of the GSH level and also significant increases in MDA, BUN and Cr was evidenced, corroborating the state of oxidative stress (39)(40)(41)(42). The human body is equipped with possesses defense systems against free-radical damage like the nonenzymatic antioxidants such as reduced GSH (41) and endogenous antioxidant enzymes such as GPx, SOD and CAT (43).…”

Section: Discussionsupporting

confidence: 87%

Ameliorative effects of hydroalcoholic extract of Lavandula officinalis L. on cyclophosphamide-induced nephrotoxicity in mice

Sadeghi¹,

Kalantar²,

Molavinia³

et al. 2017

J Nephropathol

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Background: Cyclophosphamide (CP) is amongst the most effective alkylating anticancer drugs which regardless of its harmful side effects including nephrotoxicity, hematotoxicity, mutagenicity and also immunotoxicity, commonly raised for the treatment of a number of cancers and autoimmune ailments. Objectives: This study was undertaken to investigate the ameliorative effect of Lavandula officinalis L extract (LOE) in nephrotoxicity induced by CP in mice. Materials and Methods:In this experimental study, 35 male Swiss albino mice (20-25 g) were randomly divided into 5 groups, each group consist of 7 mice. Mice were pretreated with LOE orally in doses of 100, 200 and 400 mg/kg for 5 consecutive days and CP (200 mg/kg, ip) was administrated on the fifth day 1 hour after the last dose of extract. Then on the sixth day, animals were sacrificed. Blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. Malondialdehyde (MDA), glutathione (GSH) levels and catalase (CAT) and superoxide dismutase (SOD) activity were assayed in kidney tissue. The kidney was maintained in formalin for histological examination. Results: Results showed a significant increase in the levels of MDA, Cr and BUN, and decrease of GSH, CAT and SOD by CP administration. Pre-treatment with LOE showed reduction in the levels of MDA, Cr and BUN and increase of GSH, CAT and SOD in all doses but the most significant alteration was observed at doses of 200 and 400 mg/ kg (P < 0.05). Additionally the nephroprotective effect of the LOE was established by the histological examination of the kidneys. Conclusions: Our results indicated that LOE has produced amelioration in biochemical indices and oxidative stress parameters against CP-induced nephrotoxicity.

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Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice

Cited by 87 publications

References 15 publications

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Spirulina protects against cadmium-induced hepatotoxicity in rats

Ameliorative effects of hydroalcoholic extract of Lavandula officinalis L. on cyclophosphamide-induced nephrotoxicity in mice

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