Effect of soybean feeding on experimental carcinogenesis—III. Carcinogenecity of nitrite and dibutylamine in mice: a histopathological study

Mokhtar, Nadia; El-Aaser, Abdelbaset Anwer; El-Bolkainy, Mohamed N.; Moustapha, Moustapha E.; El-Din, Nariman Badr; Moharram, Nagia Z.

doi:10.1016/s0277-5379(98)90009-8

Cited by 42 publications

(12 citation statements)

References 9 publications

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“…In contrast, a number of studies have suggested that high consumption of fruits and vegetables decreases the risk of bladder cancer (6)(7)(8). Although the anti-angiogenic activity of food components has received increased attention as a strategy for bladder cancer prevention, there are too few or conflicting studies to formulate accurate guidelines, such as vitamins C and E and selenium, studies demonstrating benefits are balanced by studies demonstrating no benefits (9)(10)(11)(12)(13)(14)(15). Other natural products, such as soy, green tea and isothiocyanates, have been suggested by some studies to be protective and by others to be tumor-promoting (16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

Zhang

Hamada

et al. 1994

Oncol Rep

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Abstract. Bladder cancer is a common but serious malignancy. It is widely accepted that chemoprevention may be an effective way to decrease the rate of recurrence and morbidity. We first determined antigrowth and apoptosis-induction activity of fucoxanthin from dietary Laminaria japonica against EJ-1 human bladder cancers. Fucoxanthin significantly reduced the cell viability in a dose-and time-dependent manner. The induction of apoptosis in EJ-1 cells was characterized by morphological changes, DNA ladder, and increased percentage of hypodiploid cells, activating caspase-3 activity. The ratio of apoptotic cells reached >93% after treatment for 72 h with 20 μM fucoxanthin. The findings obtained indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in bladder cancer cells by modulating cell viability.

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Section: Introductionmentioning

confidence: 99%

Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

Zhang

Hamada

et al. 1994

Oncol Rep

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“…In the United States of America it can be used only as a mixture with salt (sodium chloride) containing a maximum of 0.6% sodium nitrite 11,15,25,26 .…”

Section: Discussionmentioning

confidence: 99%

“…Tumors have been induced in most organs of rodents and other animals by administration of different types of these compounds under very variable experimental conditions 11,15 .…”

Section: The Jejunoileal Bypass Provokes Morphological Changes In Thementioning

confidence: 99%

The jejunoileal bypass provokes morphological changes in the large intestine? An experimental study in rats

et al. 2012

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PURPOSE: To analyse histopathological alterations characterized by the mitotic index in the mucosa of the large intestine in Wistar rats submitted to jejunoileal bypass operation after continued administration of sodium nitrite and vitamin C to different groups. METHODS: Eighty male Wistar rats were employed and separated into 12 groups. In the control group (20 rats): five animals ingested only water; five animals received vitamin C; five animals received sodium nitrite and five received sodium nitrite + vitamin C. In the sham group (20 rats), the animals were anesthetized and underwent midline laparotomy and only intestinal manipulation was performed: five animals ingested only water; five animals received vitamin C; five animals received sodium nitrite and five received sodium nitrite + vitamin C. In the operated group 40 rats underwent a jejunoileal bypass surgery: ten animals ingested only water; ten animals received vitamin C; ten animals received sodium nitrite and ten received sodium nitrite + vitamin C. The mean weight of the animals was measured weekly. The large intestine was subdivided into cecum (S1), ascending colon (S2), transverse colon (S3), descending colon (S4) and rectum (S5) for histopathological analysis and mitotic counts. The statistical analysis was used to compare the mitotic indices. The level of significance was 5%. RESULTS: The mean of all the segments indicates that the sodium nitrite+vitamin C group obtained the lowest mitotic index compared to the other treatments in the control group. The segments S1 and S2 showed a statistical difference with the vitamin C treatment: a higher mitotic index and better preservation of the mucosa in the operated group. In the sham group the main statistical difference occurred only in the sodium nitrite+vitamin C group between the means of the segments. CONCLUSIONS: The comparison of all the colonic segments of the various groups revealed a lower mitotic index in the animals treated with sodium nitrite+vitamin C. In addition, it was found that vitamin C did not present a statistically significant inhibiting effect on the preservation of the mucosa and the mitotic index.

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“…9 Another group used the nitrosamine precursor DBA and nitrite to induce bladder and liver cancers in Swiss albino mice and found that addition of soybeans to their water or feed reduced dysplastic features and completely prevented the occurrence of both bladder and liver tumors. 43 Laboratory-based studies suggest that isoflavones may inhibit tumorigenesis either by inhibiting cell cycle progression 44,45 or by inducing apoptosis. 9,45 In addition, in vitro studies have shown isoflavones to inhibit angiogenesis 45 and proliferation of hepatic stellate cells, a key player in liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Relationship of hepatocellular carcinoma to soya food consumption: A cohort‐based, case‐control study in Japan

Sharp

Lagarde

Mizuno

et al. 2005

Intl Journal of Cancer

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To determine if the risk of hepatocellular carcinoma (HCC) is reduced by consumption of soya foods, we conducted a case-control study within a cohort of Japanese A-bomb survivors. We compared the prediagnosis consumption of isoflavone-rich miso soup and tofu to HCC risk, adjusting for hepatitis B (HBV) and C (HCV) viral infections, the major HCC risk factors in this population. The study included 176 pathologist-confirmed cases of HCC diagnosed in 1964-1988 and 560 controls who died of diseases other than liver cancer. We examined dietary information collected at least 2 years before diagnosis or death and tissue-based measures of viral hepatitis. Using logistic regression, crude ORs were 0.5 (95% CI 0.29-0.95) and 0.5 (95% CI 0.20-0.99) for high vs. low miso soup and tofu intake, respectively. Adjusting for year of birth, sex, HBV, HCV and other factors, the OR for miso soup was unchanged at 0.5 (95% CI 0.14-1.55), and miso results were similar when ORs were recalculated separately for earlier and later birth cohorts to assess consistency of results. The adjusted OR for tofu was 0.9 (95% CI 0.20-3.51). We also found a statistically significant (p < 0.0001) interaction between sex and HCV, with risk of HCC being substantially higher for women. We conclude that consumption of miso soup and other soya foods may reduce HCC risk. ' 2005 Wiley-Liss, Inc.

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Effect of soybean feeding on experimental carcinogenesis—III. Carcinogenecity of nitrite and dibutylamine in mice: a histopathological study

Cited by 42 publications

References 9 publications

Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

The jejunoileal bypass provokes morphological changes in the large intestine? An experimental study in rats

Relationship of hepatocellular carcinoma to soya food consumption: A cohort‐based, case‐control study in Japan

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