Effect of some calcium channel blockers in experimentally induced diabetic nephropathy in rats

Yousef, Wael Mohamed; Omar, Adel; Ghanayem, Naglaa M; El-Wahed, M M Moshira Mohamed Abd; Morsy, Mohamed D

doi:10.1159/000497591

Cited by 9 publications

(8 citation statements)

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“…Diabetes increased the BUN and plasma CRE level in rats. Elevated levels of BUN and CRE have been documented in experimental 16 and human 17 diabetes. Low dose of vitamin E caused a slight but not significant reduction in BUN and CRE level.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats

Shamsi

Amin

Adeghate

2006

Annals of the New York Academy of Sciences

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Diabetes is associated with hyperglycemia, one of the most important causes of oxidative stress. Endogenous antioxidants are able to destroy the reactive species and create a balance between antioxidant and free radicals. In diabetes, the oxidative stress is increased due to the deficiency in the antioxidant defense. The intake of antioxidants, such as vitamin E, may reduce the oxidative stress associated with diabetes and hence help to restore the antioxidant defense system. The aim of this article was to investigate the effect of different doses of vitamin E on the biochemical parameters of normal and streptozotocin (STZ)-induced diabetic rats. Biochemical analysis was used to study the effect of this vitamin on the biochemical parameters of normal and diabetic rats. The plasma levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactic dehydrogenase (LDH), and gamma-glutamyl transferase (gamma-GT) were significantly increased after the onset of diabetes. In addition, STZ-induced diabetes also caused an increase in the level of blood urea nitrogen (BUN) and creatinine. Oral administration of vitamin E (0.2-0.4 mg daily) significantly (P < 0.05) decreased the plasma level of ALT, AST, and gamma-GT. In addition, there was a slight but not significant reduction in the plasma level of ALP. Parameters of kidney function, such as BUN and creatinine, were slightly reduced after the oral administration of vitamin E. The plasma level of electrolytes, such as calcium and sodium, also changed significantly (P < 0.00001) after the oral administration of vitamin E. Vitamin E ameliorates the metabolic and biochemical parameters of diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats

Shamsi

Amin

Adeghate

2006

Annals of the New York Academy of Sciences

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“…The observed effect of cinnamon oil on lipid profile may be due to its insulin facilitatory action. The urea clearance in diabetic condition has been reported to decrease, and the serum level of urea to increase [4]. The treatment of diabetic rats with cinnamon oil was found to attenuate this increased serum urea level significantly.…”

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confidence: 95%

“…Before the onset of overt proteinuria, various renal functional changes are observed including renal hyperfiltration, hyperfusion, and increased capillary permiability to macromolecules. These alterations are accompanied by ultra structural changes including glomerular basement membrane thickening, mesangial expansion [2], glomerular hypertrophy with the later development of glomerulosclerosis, tubulointerstitial fibrosis and large proteinaceous deposits in glomerular space, hya-line droplets within the glomeruli, and hyaline cast within the tubule [3,4]. Numbers of mechanisms such as increased production of free radicals, decreased antioxidant machinery of the cells [5,6], glycooxidation [7], formation of advanced glycation products, activation of polyol pathway [8], altered glutathione redox status [9], ascorbate metabolism [10], antioxidant enzyme inactivation [11], and altered nitric oxide and prostaglandin metabolism [12] have been implicated in the pathophysiology of diabetes and its complications.…”

mentioning

confidence: 99%

“…Early changes in the diabetic kidney include mesangial expansion, deposition of extra cellular matrix protein, and altered mesangial cell proliferation [31]. Light microscopic examination of the diabetic kidney has been documented to show glomerulopathy characterized by thickening of the glomerular basement membrane, mesangial matrix expansion, arteriolar hyalinosis, insudative large proteinaceous deposits occluding some capillary loops, hyaline proteinaceous droplets within the glomeruli, hyaline cast, and tubular dilatation [3,4]. The histological resurgence of the kidneys in the present study supports the significant renal biochemical changes.…”

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confidence: 99%

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Ameliorative Effect of the Cinnamon Oil fromCinnamomum zeylanicumupon Early Stage Diabetic Nephropathy

et al. 2009

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The current study was designed to evaluate the ameliorative effect of the cinnamon oil upon early stage diabetic nephropathy owing to its antioxidant and antidiabetic effect. Cinnamon oil was extracted by hydro-distillation of the dried inner bark of Cinnamomum zeylanicum Blume. Further characterization of the extracted oil was carried out using IR, (1)H-NMR, and (13)C-NMR techniques. Early stage of diabetic nephropathy was induced by administration of alloxan (150 mg/kg, I. P.). Cinnamon oil was administered at varying doses (5, 10, 20 mg/kg; I. P.) while the level of fasting blood glucose, total cholesterol, high density lipoprotein, urea, thiobarbituric acid reactive substances, reduced glutathione, and catalase were determined. These parameters in cinnamon oil treated groups were compared with those of standard (glipizide; 10 mg/kg) and vehicle treated groups in order to investigate if cinnamon oil confers a significant protection against diabetic nephropathy. Histological studies of the kidney proved the protective effect of cinnamon oil by reducing the glomerular expansion, eradicating hyaline casts, and decreasing the tubular dilatations. Our results indicate that the volatile oil from cinnamon contains more than 98 % cinnamaldehyde and that it confers dose-dependent, significant protection against alloxan-induced renal damage, the maximum decrease in fasting blood glucose having been achieved at the dose of 20 mg/kg.

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“…Kidney sections of diabetic rats showed an increase in mesangial cell and matrix of glomeruli with increase in glycogen deposition and hyalinization of arterioles with thickened basement membranes of proximal and distal convoluted tubules. These changes will lead to progressive reduction in the filtration surface of the glomeruli [35]. Histological examination of the kidney of the control rats showed normal structure of renal glomerular.…”

Section: Kidney Histopathological Observationsmentioning

confidence: 95%

Trigonella Foenum Graecum Extract Benefits on Hematological, Biochemical and Male Reproductive System of as a Complementary Therapy with Glimepiride in Treating Streptozotocin Induced Diabetic Rats

El-Ghazaly

Zaatout

Radwan

et al. 2019

JBD

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Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin is a naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals and induces diabetes. Glimepiride is a second generation sulfonylurea, used as second-line or add-on treatment options for type 2 diabetes. Fenugreek (Trigonellafoenum graecum) seeds have been documented as a traditional plant treatment for diabetes. Soluble dietary fiber of Fenugreek significantly improved oral glucose tolerance in diabetic rats. It also exerts anti-diabetic effects mediated through the inhibition of carbohydrate digestion and absorption and the enhancement of peripheral insulin action. Most herbal remedies can interact with allopathic drugs resulting in altered activity and toxicity. At the same time, herbal remedies might produce the same kind of effects as the drug produce. Current published research information on herb-drug interactions is scanty. So, the aim of this study was to investigate the possible interaction between conventional drug used for the management of diabetes; (Glimepiride) and a traditional herbal remedy; Fenugreek aqueous extract in Streptozotocin induced diabetic male albino rats. In conclusion, combination therapy induces better hematological, biochemical effects and improves the oxidative stress biomarkers and antioxidant enzymes. Histological studies showed better results on some organ functions. The results emphasize the benefit of using the combination of Fenugreek seeds aqueous extracts as supportive complementary anti-diabetic therapy.

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Effect of some calcium channel blockers in experimentally induced diabetic nephropathy in rats

Cited by 9 publications

References 0 publications

Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats

Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats

Ameliorative Effect of the Cinnamon Oil fromCinnamomum zeylanicumupon Early Stage Diabetic Nephropathy

Trigonella Foenum Graecum Extract Benefits on Hematological, Biochemical and Male Reproductive System of as a Complementary Therapy with Glimepiride in Treating Streptozotocin Induced Diabetic Rats

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