Ameliorative Effect of the Cinnamon Oil fromCinnamomum zeylanicumupon Early Stage Diabetic Nephropathy

Abstract

The current study was designed to evaluate the ameliorative effect of the cinnamon oil upon early stage diabetic nephropathy owing to its antioxidant and antidiabetic effect. Cinnamon oil was extracted by hydro-distillation of the dried inner bark of Cinnamomum zeylanicum Blume. Further characterization of the extracted oil was carried out using IR, (1)H-NMR, and (13)C-NMR techniques. Early stage of diabetic nephropathy was induced by administration of alloxan (150 mg/kg, I. P.). Cinnamon oil was administered at varying doses (5, 10, 20 mg/kg; I. P.) while the level of fasting blood glucose, total cholesterol, high density lipoprotein, urea, thiobarbituric acid reactive substances, reduced glutathione, and catalase were determined. These parameters in cinnamon oil treated groups were compared with those of standard (glipizide; 10 mg/kg) and vehicle treated groups in order to investigate if cinnamon oil confers a significant protection against diabetic nephropathy. Histological studies of the kidney proved the protective effect of cinnamon oil by reducing the glomerular expansion, eradicating hyaline casts, and decreasing the tubular dilatations. Our results indicate that the volatile oil from cinnamon contains more than 98 % cinnamaldehyde and that it confers dose-dependent, significant protection against alloxan-induced renal damage, the maximum decrease in fasting blood glucose having been achieved at the dose of 20 mg/kg.

Ameliorative effect ofAegle marmelosleaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats

“…Alloxan is well documented to induce persistent hyperglycemia by the generation of ROS (Duzguner & Kaya, 2007). These free radical species result in oxidative damage to the heart, kidneys, eyes, nerves, liver, small and large vessels and gastrointestinal system (Mishra et al, 2010). Inflammatory changes, hypertrophic remodeling and cell death have been reported to occur in the diabetic hearts in experimental animals as early as 7 days after the induction of the diabetic state (Cai et al, 2006).…”

Verification of the Antidiabetic Effects of Cinnamon (Cinnamomum zeylanicum) Using Insulin-Uncontrolled Type 1 Diabetic Rats and Cultured Adipocytes

“…[9][10][11] Cinnamon has also increased endogenous insulin production, and ameliorated the nephropathy occurring sometimes at the early stage of diabetes. [12][13][14] Most of the studies on cinnamon have therefore confirmed its diabetic effect to be insulinpotentiating, although the effects independent from insulin have not yet been elucidated. Altschuler et al have performed a prospective, double-blind, placebocontrolled study on cinnamon using adolescent type 1 diabetic subjects, and no significant effect on suppressing hemoglobin A1c was found.…”

Edible plants from traditional Chinese medicine is a promising alternative for the management of diabetic nephropathy

“…For example, cinnamaldehyde ( Fig. 1A) from C. zeylanicum has been shown to exert protective effects against alloxan-induced renal damage by reducing glomerular expansion, eradicating hyaline casts, and decreasing tubular dilatations (Mishra, Bhatti, Singh, & Singh Ishar, 2010). Another large group of polyphenolic compounds flavonoids also show anti-DN activity.…”