Effect of solvent and extraction technique on composition and biological activity of Lepidium sativum extracts

Rafińska, Katarzyna; Pomastowski, Paweł; Rudnicka, Joanna; Krakowska, Aneta; Maruška, Audrius; Narkute, Monika; Buszewski, Bogusław

doi:10.1016/j.foodchem.2019.03.025

Cited by 98 publications

(70 citation statements)

References 28 publications

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“…The present results were within the range of those found by Nawaz, Shad, and Rauf (2018) in their study on Brassica oleracea leaves extracts and the study of Rafińska et al. (2019) when working on Lepidium sativum seeds extract.…”

Section: Resultssupporting

confidence: 91%

African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals properties

Rahmani

Bouajila

Jouaidi

et al. 2020

Journal of Food Science

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Brassica tournefortii is an annual herbaceous plant, native to the North Africa and Middle East. It is considered as an excellent medicinal plant due to its richness by antioxidant like isothiocyanates and polyphenols. The present study is the first phytochemical investigation on Brassica tournefortii organs (leaves, stems, and roots) in terms of nutraceutical, chemical composition, and bioactivity. Brassica tournefortii leaves exhibited the highest values of nutraceutical contents. Interestingly, gas chromatograph‐y‐mass spectrometry (GC‐MS) analysis enabled to identify three new isothiocyanates: iberverin nitrile and iberin detected only in roots, and iberin nitrile detected in all organs. HPLC chromatograms displayed different profiles depending on organic solvent and extracted organ. Icariin and 5,7‐dihydroxy 4‐propylcoumarin showed the highest concentrations with 2.3 and 1.3 mg/g of dr among other molecules identified by high performance liquid chromatography (HPLC). Some phenolic compounds were identified in more than one organ extracts such as phenoxodiol and 4‐hydroxy‐3‐propylbenzoic acid methyl ester. Brassica tournefortii extracts showed a moderate total phenolic contents and anti‐15‐LOX activity, while they exhibited a good anti‐α‐glucosidase activity ranging from 40% to 60%. Furthermore, leaves‐MeOH and root‐dichloromethane (DCM) extracts induced the highest cytotoxicity against MCF‐7 cell lines, while roots‐cyclohexane (CYHA) extract highlighted the highest inhibition activity against, both, HCT‐116 and OVCAR cell lines.

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Section: Resultssupporting

confidence: 91%

African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals properties

Rahmani

Bouajila

Jouaidi

et al. 2020

Journal of Food Science

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“…Similar correlation was observed for extraction of Lepidium sativum freeze-dried sprouts and seeds with different techniques. The highest level of flavonoids was noticed for SFE with 96% ethanol as co-solvent-it was over 6 times as high as for maceration with 70% ethanol [28]. The effectiveness of this technique in the extraction of flavonoids from plant material was also confirmed by many other studies, for example on Maydis stigma, Scutellaria baicalensis and Ginkgo leaves [29].…”

Section: Responsesupporting

confidence: 59%

Extraction and Determination of Polar Bioactive Compounds from Alfalfa (Medicago sativa L.) Using Supercritical Techniques

et al. 2019

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The aim of this research was to select parameters for supercritical extraction with CO2 of Medicago sativa L., considered as functional food, in quarter-technical plant, providing the highest concentration of bioactive polar constituents and simultaneously maintaining the highest efficiency of the process. For the purpose of optimization, mathematical statistics was used. Qualitative analysis of products was performed with supercritical fluid chromatography (SFC). The SFC analysis revealed a proper separation of flavonoids and phenolics acids for dedicated TFC and TPC optimal parameters. The obtained results have proved that it is a possibility to extract polar compounds with non-polar solvent under higher values of pressure and temperature and to enrich product with desired group of bioactive compounds with proper optimization. The proposed extraction technique allows to obtain on an industrial scale, using an environmentally friendly solvent, a preparation rich in biologically active nutrients that can be implemented in the cosmetics, pharmaceutical and food industries.

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“…Table 2 shows some of the published works on the extraction of flavonoids using these emerging methods. AmA and CtA [47] Abbreviations…”

Section: Emerging and Advanced Methodsmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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Flavonoids are a group of plant constituents called phenolic compounds and correspond to the nonenergy part of the human diet. Flavonoids are found in vegetables, seeds, fruits, and beverages such as wine and beer. Over 7000 flavonoids have been identified and they have been considered substances with a beneficial action on human health, particularly of multiple positive effects because of their antioxidant and free radical scavenging action. Although several studies indicate that some flavonoids have provident actions, they occur only at high doses, confirming in most investigations the existence of anti-inflammatory effects, antiviral or anti-allergic, and their protective role against cardiovascular disease, cancer, and various pathologies. Flavonoids are generally removed by chemical methods using solvents and traditional processes, which besides being expensive, involve long periods of time and affect the bioactivity of such compounds. Recently, efforts to develop biotechnological strategies to reduce or eliminate the use of toxic solvents have been reported, reducing processing time and maintaining the bioactivity of the compounds. In this paper, we review, analyze, and discuss methodologies for biotechnological recovery/extraction of flavonoids from agro-industrial residues, describing the advances and challenges in the topic.

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Effect of solvent and extraction technique on composition and biological activity of Lepidium sativum extracts

Cited by 98 publications

References 28 publications

African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals properties

African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals properties

Extraction and Determination of Polar Bioactive Compounds from Alfalfa (Medicago sativa L.) Using Supercritical Techniques

Conventional and Emerging Extraction Processes of Flavonoids

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