Effect of sodium selenite and methyl methanesulfonate or N-hydroxy-2-acetylaminofluorene co-exposure on sister-chromatid exchange production in human whole blood cultures☆

Ray, James H.; Altenburg, Lewis C.; Jacobs, Maryce M.

doi:10.1016/0027-5107(78)90220-8

Cited by 10 publications

(1 citation statement)

References 33 publications

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“…9 5~1 O -~M , at least at our laboratory. These results differ from those by RAY et al (1978). who exposed blood cells to Na2Se03 concentrations of 1 .…”

Section: Discussioncontrasting

confidence: 99%

Protective effect of selenium against arsenic-induced chromosomal damage in cultured human lymphocytes

Sweins

2008

Hereditas

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Combined effects of Na2SeO3 and NaAsO2 were studied on the chromosomes of cultured human lymphocytes. The cells were exposed to selenium and/or arsenic for 48 hours, and the total culture time was 72 hours. Two arsenic concentrations were combined with three different selenium concentrations. Arsenic produced increased frequencies of chromosomal aberrations, while selenium had a modest clastogenic effect. Selenium was found to reduce the frequency of gaps and chromatid breaks induced by arsenic, while no certain effect on the frequency of chromosome breaks was observed. The reducing effect of selenium was smaller when the cells were exposed to a higher arsenic dose.

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“…9 5~1 O -~M , at least at our laboratory. These results differ from those by RAY et al (1978). who exposed blood cells to Na2Se03 concentrations of 1 .…”

Section: Discussioncontrasting

confidence: 99%

Protective effect of selenium against arsenic-induced chromosomal damage in cultured human lymphocytes

Sweins

2008

Hereditas

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Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing

Gebhart

1981

Hum Genet

175

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Data from previous studies published on the induction by mutagens of sister chromatid exchanges (SCEs) and structural chromosome damage were compared qualitatively and quantitatively. Although a good correlation between the incidence of both cytogenetic phenomena has been pointed out in many previous publications, about 30% of the agents for which comparable data were available yielded non-corresponding qualitative results concerning both indicator effects. However, even in groups with good qualitative agreement distinct quantitative differences indicated different molecular mechanisms of the formation of SCEs and breaks. Additional information supporting the importance of these differences for the validity of both indicator systems has been derived from the results obtained using strong clastogens exhibiting a low or no SCE-inducing activity and vice versa, from special observations on chromosomal breakage syndromes, and from studies on the action of known co- and anti-clastogens on SCE-induction by chemical mutagens. As a result, it has been suggested that the SCE-technique should be considered as a valuable additional method for cytogenetic mutagenicity testing, which, however, is not adequate to replace the classical methods of analysis of structural chromosome damage.

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Effects of selenium on chemical carcinogens

Jacobs¹

1980

Preventive Medicine

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Effect of sodium selenite and methyl methanesulfonate or N-hydroxy-2-acetylaminofluorene co-exposure on sister-chromatid exchange production in human whole blood cultures☆

Cited by 10 publications

References 33 publications

Protective effect of selenium against arsenic-induced chromosomal damage in cultured human lymphocytes

Protective effect of selenium against arsenic-induced chromosomal damage in cultured human lymphocytes

Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing

Effects of selenium on chemical carcinogens

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