Abstract:Data from previous studies published on the induction by mutagens of sister chromatid exchanges (SCEs) and structural chromosome damage were compared qualitatively and quantitatively. Although a good correlation between the incidence of both cytogenetic phenomena has been pointed out in many previous publications, about 30% of the agents for which comparable data were available yielded non-corresponding qualitative results concerning both indicator effects. However, even in groups with good qualitative agreeme… Show more
“…The clastogenic effect of several cytostatic agents has been documented (2,4,7,15,19). The present results, together with those of previous studies, suggest that even seemingly small doses can change genetic material.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study the known environmental factors, such as radiation, viral diseases, chemicals, drugs, and smoking (7,13), were evaluated carefully. With respect t o these factors there were n o clear group differences which could explain the greater number of chromosome breaks in the oncologic nurses.…”
Section: Discussionmentioning
confidence: 99%
“…Cytostatic agent5 have been shown to cause chromosome aberrations and sister chromatid exchanges both in vitro (2,3,7,16,19) and in cells of patients after cytostatic therapy (1, 4, 8, 9, 10, 14, 15, 16).…”
“…The clastogenic effect of several cytostatic agents has been documented (2,4,7,15,19). The present results, together with those of previous studies, suggest that even seemingly small doses can change genetic material.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study the known environmental factors, such as radiation, viral diseases, chemicals, drugs, and smoking (7,13), were evaluated carefully. With respect t o these factors there were n o clear group differences which could explain the greater number of chromosome breaks in the oncologic nurses.…”
Section: Discussionmentioning
confidence: 99%
“…Cytostatic agent5 have been shown to cause chromosome aberrations and sister chromatid exchanges both in vitro (2,3,7,16,19) and in cells of patients after cytostatic therapy (1, 4, 8, 9, 10, 14, 15, 16).…”
“…They are not generally associated with cell death. 3 SCEs induced bv a number of chemicals exhibit a clear dose -re.sponse relationship, irrespective of whether cells are exposed in vivo or in vitro; 1 and 463 then generally provide a more sensitive indication of chemical exposure than chromosom e aberrations. Th's sensitivity often results in observations of high SCE frequen cies at chemical concentrations that induce few,.…”
Section: Sister Chromatid Exchangementioning
confidence: 99%
“…Although most investigators believe that an increased SCE frequency indicates chromosome damage, the biological significance of SCE is not clear. 1 Certain powerful mutagens, such as ionizing rudiation and some chemicals, cause only small increases in SCE frequency, whereas some weak carcinogens readily induce SCEs.…”
Reported effects of ultrasound on sister chromatid exchange have been contradictory. These studies are discussed and their results , including ultrasonic dosimetry and biologic considerations, are compared. In the few studies showing positive effects, the magnitude was small, and the eflects occurred as a result of in vitro exposure. Based on a review of these reports, there does not appear to be sufficient reason to alter presently held views on the safety of clinical ultrasound. (Key words: sister chromatid exchange; ultrasound safety; biologic effects) Several papers have recently appeared in the ultrasonic bioeffects literature that examine the effect of ultrasound on sister chromatid exchange (SCE) frequency in a number of biological sys tems.
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