Effect of Sodium Bicarbonate on the Properties of Metronidazole Floating Matrix Tablets

Gutiérrez-Sánchez, Pablo Emilio; Hernández-León, Alejandra; Villafuerte-Robles, Leopoldo

doi:10.1080/03639040701506478

Cited by 24 publications

(10 citation statements)

References 35 publications

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“…We assume that the released CO 2 is weakening the created gel, thus leading to the observed rapid decomposition. This is in accordance with an observation of Gutiérrez-Sánchez et al that report the weakening effect of gas generation by sodium bicarbonate on HPMC-based tablets (Gutierrez-Sanchez et al, 2008).…”

Section: Duration Of Floating and Decomposition Timesupporting

confidence: 81%

Development andin vitrocharacterization of floating sustained-release drug delivery systems of polyphenols

et al. 2013

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The aim of this study was to develop and characterize floating stomach-retentive matrix tablets that will deliver polyphenols in a controlled release manner. The tablets were prepared by direct compression. A number of polymers were examined and egg albumin was chosen in light of a better performance in terms of floating behavior and decomposition time. Dissolution studies for three representative polyphenols loaded into a number of formulations were performed using the ''f 2 '' factor in order to compare release profiles of different polyphenols and formulations. The release data showed a good fit into the power law equation and zero-order kinetics has been determined for some of the systems. Erosion and textural analysis studies revealed that higher concentration of egg albumin results in a higher gel strength that is less susceptible to erosion, potentially leading to a prolonged delivery time of drug. The ability of egg albumin-based tablets to resist high mechanical forces was also determined, while comparison to cellulose-derived polymers revealed that the latter have a much lower ability to resist the same forces. The developed delivery system has the potential to increase the efficacy of the therapy for various pathological stomach conditions and to improve patient compliance.

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Section: Duration Of Floating and Decomposition Timesupporting

confidence: 81%

Development andin vitrocharacterization of floating sustained-release drug delivery systems of polyphenols

et al. 2013

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“…However with time methocel showed good swelling capacity due to high hydration properties. [27] Also swelling index of all tablets increased with time because of the increase in hydration rate of polymers with time. On imbibition of more and more water by polymers, gel floating is formed at the outer surface which depends mainly on polymer concentration and viscosity.…”

Section: Swelling Studiesmentioning

confidence: 98%

“…Carbon dioxide bubbles, obtained after reaction of sodium bicarbonate or calcium carbonate with the acidic dissolution medium, expand the floating volume and produce a reinforcement of the tablet's floatability. [27] Carbon dioxide bubbles show a trend to disappear progressively with time as the hydration of tablet progresses. The presence of citric acid increases the carbon dioxide bubbles and hence decreases the floating lag time in formulation E4 compared to P7.…”

Section: Effect Of Excipientsmentioning

confidence: 98%

Effect of polymers and excipients on the release kinetics, bioadhesion, and floatability of metronidazole tablet

Arora¹,

Rd²

2011

Asian J Pharm

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S tomach-specific floating tablet of metronidazole based on the buoyancy and bioadhesion concept was prepared with a purpose to retain the drug in stomach for longer duration and helps in releasing the drug in the antrum region of gastric mucosa, a safe heaven for Helicobacter pylori. This research work systematically studied the effects of various polymeric blends of bioadhesive polymers namely chitosan and carbopol 971P with low density polymer-methocel K100LV on the desired in vitro drug release profile in the stomach, buoyancy, swelling index, and mucoadhesion of tablet formulation. Chitosan and carbopol 971P concentration significantly influence the in vitro drug release and bioadhesion strength. An increase in buoyancy was observed with increase in Methocel K100LV concentration in the polymeric blend. The increase in buoyancy and drug release was obtained in the presence of microcrystalline cellulose, sodium bicarbonate, and sodium citrate. The optimum formulation provides desired high drug concentration (~35%) during 1 hour and sustained release up to 12 hours, following the Higuchi model. The mechanism of release of metronidazole from the floating bioadhesive tablets was anomalous diffusion transport. The studies indicated successful formulation of gastroretentive compressed tablet with excellent controlled release, mucoadhesion, and hydrodynamic balance.

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“…[12] The most common approach for floating matrix tablets is to use a mixture of hydrophilic polymer and gas generating agent like sodium bicarbonate in the formulation. [13] CO 2 gas is generated when sodium bicarbonate reacts with acidic medium and it provides buoyancy to the dosage form by its entrapment within hydrophilic polymer network. However, the effectiveness of this type of system can be reduced by fluctuation in gastric pH due to factors like disease condition and presence of food.…”

Section: Introductionmentioning

confidence: 99%

Development of non-effervescent floating matrix tablets based on Euryale ferox seeds

Negi¹,

Kasliwal²,

Jugran³

2011

Asian J Pharm

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E uryale ferox (family Nymphaeaceae), a plant belonging to the water lily family, grows in water ponds and remains buoyant on water surface. Similarly, its edible seeds also remain afloat in a wide variety of liquid mediums. Thus, the purpose of this study was to develop non-effervescent floating matrix tablets using E. ferox seeds powder (EFSP). Different matrix tablets were prepared using hydroxy propyl methyl cellulose (HPMC) K4M, ciprofloxacin HCl and EFSP. The effects of various formulation variables were investigated on in vitro drug release and in vitro floating behavior of the matrix tablets. With increase in EFSP proportion in the matrix tablets, improvement in buoyancy was observed. The floating behavior of tablets was also found to be dependent on particle size of EFSP. Further, surface morphology of different particle sizes of EFSP was studied with Scanning Electron Microscope images. Drug release from matrix tablets was reduced in the presence of EFSP particles. Most of the formulations were best fitted with Korsmeyer-Peppas and zero-order release kinetics. The value of n was found to be between 0.45 and 0.89, which indicates non-fickian drug transport. Thus, non-effervescent floating behavior can be successfully achieved by using EFSP in HPMC K4M based matrix tablets. How to cite this article: Negi JS, Jugran V, Kasliwal N. Development of non-effervescent floating matrix tablets based on Euryale ferox seeds. Asian J Pharm 2011;5:93-100. Optimized content for mobile and hand-held devicesHTML pages have been optimized of mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)

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Effect of Sodium Bicarbonate on the Properties of Metronidazole Floating Matrix Tablets

Cited by 24 publications

References 35 publications

Development andin vitrocharacterization of floating sustained-release drug delivery systems of polyphenols

Development andin vitrocharacterization of floating sustained-release drug delivery systems of polyphenols

Effect of polymers and excipients on the release kinetics, bioadhesion, and floatability of metronidazole tablet

Development of non-effervescent floating matrix tablets based on Euryale ferox seeds

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