E uryale ferox (family Nymphaeaceae), a plant belonging to the water lily family, grows in water ponds and remains buoyant on water surface. Similarly, its edible seeds also remain afloat in a wide variety of liquid mediums. Thus, the purpose of this study was to develop non-effervescent floating matrix tablets using E. ferox seeds powder (EFSP). Different matrix tablets were prepared using hydroxy propyl methyl cellulose (HPMC) K4M, ciprofloxacin HCl and EFSP. The effects of various formulation variables were investigated on in vitro drug release and in vitro floating behavior of the matrix tablets. With increase in EFSP proportion in the matrix tablets, improvement in buoyancy was observed. The floating behavior of tablets was also found to be dependent on particle size of EFSP. Further, surface morphology of different particle sizes of EFSP was studied with Scanning Electron Microscope images. Drug release from matrix tablets was reduced in the presence of EFSP particles. Most of the formulations were best fitted with Korsmeyer-Peppas and zero-order release kinetics. The value of n was found to be between 0.45 and 0.89, which indicates non-fickian drug transport. Thus, non-effervescent floating behavior can be successfully achieved by using EFSP in HPMC K4M based matrix tablets. How to cite this article: Negi JS, Jugran V, Kasliwal N. Development of non-effervescent floating matrix tablets based on Euryale ferox seeds. Asian J Pharm 2011;5:93-100.
Optimized content for mobile and hand-held devicesHTML pages have been optimized of mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)
The present study was undertaken to develop and evaluate an oro-dispersible, sustained release tablet of metoclopramide HCl. The technology was comprised of developing sustained release microparticles, and compression of resultant microspheres into a fast dispersible tablet by direct compression. The microspheres of metoclopramide HCl were prepared by an emulsification-solvent evaporation method using ethylcellulose as the matrix polymer. The prepared microspheres were evaluated for morphology, particle size, entrapment efficiency, and in vitro drug release characteristics. Scanning electron microscopy demonstrated spherical particles with a mean diameter of 81.27 ± 5.87 μm and the drug encapsulation efficiency was found to be 70.15 ± 3.06%. The process and formulation variables such as rotation speed, polymer concentration, and drug concentration influenced the drug encapsulation efficiency and in vitro drug release. Optimized microspheres were compressed into tablets which were comprised of metoclopramide HCl microspheres, 53% (w/v) of D-mannitol granules, 7% (w/w) of Polyplasdone XL 10, and 0.5% (w/w) of calcium stearate. The tablets demonstrated a hardness of 59 ± 3 N, friability of 0.21% and disintegration time of 27 ± 3 sec. The formulations were subjected to stability studies as per ICH guidelines and were found to be stable after a 6 month study. In vivo experiments conducted in rats demonstrated that a constant level of metoclopramide HCl in plasma could be maintained for up to 20 h at a suitable concentration for antiemetic activity. An appropriate combination of excipients made it possible to obtain orally disintegrating sustained release tablets of metoclopramide HCl using simple and conventional techniques.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.