Effect of Sodium Amylosulfate (Depepsen) on the Healing of Duodenal Ulcer

Double-blind randomised clinical trial of a pepsin-inhibitory pentapeptide (pepstatin) in the treatment of duodenal ulcer.

“…Antacid consumption was modest and equal in the test and control groups, the proportions of inpatients were likewise equal in the two groups, and, finally, examination of the standard error of the treatment difference in the two patient groups (SED: 0-135) suggested that a true effect favouring pepstatin concealed by random variation in small numbers should not exceed 18'5 %, this would be clinically insignificant. Apart from these considerations the present study is in agreement with a trial by Landecker et al (1976), who found no advantage in amylopectin over placebo. In the development of experimental ulcers the presence of peptic activity was shown to be an important factor (Alphin et al, 1977).…”

“…Amylopectin sulphate seems to accelerate gastric ulcer healing (Zimmon et al, 1969) and to promote a prophylactic effect on the recurrence rate of duodenal ulcer (Sun and Ryan, 1970). However, the drug has been reported to have neither a direct symptomatic effect in patients with radiologically demonstrated duodenal ulcer (Cocking, 1972;Baron, et al, 1977) nor an influence on the ulcer healing rate in patients with an active duodenal ulcer, when evaluated radiologically (Cocking, 1972) and endoscopically (Landecker et al, 1976).…”

Double-blind controlled trial of amylopectin sulphate (Depepsen) in the symptomatic treatment of duodenal ulcer.

“…These results differ from the significant benefit with amylopectin sulphate 250 mg two hourly reported by Sun and Ryan (1970) and Sun (1974). However, in a trial using amylopectin sulphate and propantheline, Cocking (1972) could show no advantage for amylopectin sulphate 500 mg every three hours over a placebo, and in a recent endoscopically controlled eight week trial Landecker et al (1976) also found no advantage for amylopectin.…”

A Controlled Clinical Trial of Sucralfate in the Treatment of Gastric Ulcer

“…Amylopectin sulphate is a similar preparation which has been investigated during the last ten years. Although an early trial in gastric ulcer showed that it accelerated healing (Zimmon et al, 1969) subsequent trials gave rather indifferent results and a recent study by Landecker et al, (1976) has shown that it has no effect in duodenal ulcer.…”