Effect of SOD-Mimetic Fe-Chlorine e6-Na on the Level of Brain Lipid Peroxide of Rat Fetal Brains Exposed to Reactive Oxygen Species Leading to Intrauterine Growth Retardation

Saito, Kazuru; Maeda, Mika; Yoshihara, Hajime; Amano, Kazutaka; Nishijima, Masahiro; Nakamura, Kohei

doi:10.1159/000014204

Cited by 6 publications

(3 citation statements)

References 19 publications

(27 reference statements)

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“…Since fish micronutrients are assumed to possess antioxidant activity, they may protect tissues and cells by reacting with oxygen free radicals generated by metabolites of PAHs or other ambient toxicants present in fine particulate matter and counteract oxidative DNA damage [44][45][46][47] . Animal studies have already shown that reactive oxygen species and oxidative stress are associated with poor fetal growth [48,49] . Evidence from studies of pregnant women also suggests that oxidative stress plays a role in low birth weight [50,51] .…”

Section: Discussionmentioning

confidence: 99%

Higher Fish Consumption in Pregnancy May Confer Protection against the Harmful Effect of Prenatal Exposure to Fine Particulate Matter

Jędrychowski

Perera²,

Mrozek-Budzyn³

et al. 2010

Ann Nutr Metab

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Background/Aim: The objective of this study was to assess a hypothesized beneficial effect of fish consumption during the last trimester of pregnancy on adverse birth outcomes resulting from prenatal exposure to fine air particulate matter. Methods: The cohort consisted of 481 nonsmoking women with singleton pregnancies, of 18–35 years of age, who gave birth at term. All recruited women were asked about their usual diet over the period of pregnancy. Measurements of particulate matter less than 2.5 µm in size (PM_2.5) were carried out by personal air monitoring over 48 h during the second trimester of pregnancy. The effect of PM_2.5 and fish intake during gestation on the birth weight of the babies was estimated from multivariable linear regression models, which beside the main independent variables considered a set of potential confounding factors such as the size of the mother (height, prepregnancy weight), maternal education, parity, the gender of the child, gestational age and the season of birth. Results: The study showed that the adjusted birth weight was significantly lower in newborns whose mothers were exposed to particulate matter greater than 46.3 µg/m³ (β coefficient = –97.02, p = 0.032). Regression analysis stratified by the level of maternal fish consumption (in tertiles) showed that the deficit in birth weight amounted to 133.26 g (p = 0.052) in newborns whose mothers reported low fish intake (<91 g/week). The birth weight deficit in newborns whose mothers reported medium (91–205 g/week) or higher fish intake (>205 g/week) was insignificant. The interaction term between PM_2.5 and fish intake levels was also insignificant (β = –107,35, p = 0.215). Neither gestational age nor birth weight correlated with maternal fish consumption. Conclusions: The results suggest that a higher consumption of fish by women during pregnancy may reduce the risk of adverse effects of prenatal exposure to toxicants and highlight the fact that a full assessment of adverse birth outcomes resulting from prenatal exposure to ambient hazards should consider maternal nutrition during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Higher Fish Consumption in Pregnancy May Confer Protection against the Harmful Effect of Prenatal Exposure to Fine Particulate Matter

Jędrychowski

Perera²,

Mrozek-Budzyn³

et al. 2010

Ann Nutr Metab

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“…Additionally, vitamin A, the carotenoids, and vitamin E possess antioxidant activity and protect tissues and cells by reacting with oxygen free radicals (14). Animal studies have shown that reactive oxygen species and oxidative stress are associated with poor fetal growth (34,35), and evidence from studies of pregnant women suggests that oxidative stress plays a role in low birth weight (36,37). Compounds with antioxidant activity may help to protect the developing fetus and could therefore play a role in fetal growth and development.…”

Section: Discussionmentioning

confidence: 99%

Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes

Masters

Jędrychowski

Schleicher

et al. 2007

The American Journal of Clinical Nutrition

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“…Reactive oxygen species and oxidative stress have also been associated with poor fetal growth in animal studies. Oxidative stress was associated with the presence of intrauterine growth retardation and fetal weight in rat and pig models (5). Coenzyme Q10 (CoQ10 or ubiquinone) is an essential component of the mitochondrial electron transport chain and is also present in various cellular membranes and in plasma lipoproteins.…”

Section: Introductionmentioning

confidence: 99%

Amniotic Coenzyme Q10: Is It Related to Pregnancy Outcomes?

Raffaele

Tiano²,

Ciavattini³

et al. 2014

Antioxidants & Redox Signaling

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Coenzyme Q10 (CoQ10 or ubiquinone) is an essential component of the mitochondrial electron transport chain and is also present in various cellular membranes and in plasma lipoproteins. Diabetes, cardiovascular, neurodegenerative, and preeclampsia diseases are all associated with an alteration of CoQ10 level or its redox status. During pregnancy, we note that the plasma content of CoQ10 is significantly higher than amniotic. In the fetal growth restriction group, amniotic total CoQ10 levels were significantly higher versus healthy, while the amniotic oxygen radical absorbing capacity level was significantly lower. A significant negative correlation was observed between amniotic total CoQ10 and birthweight. Our observation leads to the hypothesis that the amniotic midtrimester CoQ10 content may be a marker of subsequent obstetric complications. Antioxid. Redox Signal. 21, 1582-1586.

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Effect of SOD-Mimetic Fe-Chlorine e6-Na on the Level of Brain Lipid Peroxide of Rat Fetal Brains Exposed to Reactive Oxygen Species Leading to Intrauterine Growth Retardation

Cited by 6 publications

References 19 publications

Higher Fish Consumption in Pregnancy May Confer Protection against the Harmful Effect of Prenatal Exposure to Fine Particulate Matter

Higher Fish Consumption in Pregnancy May Confer Protection against the Harmful Effect of Prenatal Exposure to Fine Particulate Matter

Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes

Amniotic Coenzyme Q10: Is It Related to Pregnancy Outcomes?

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