Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes

Masters, Elizabeth T.; Jędrychowski, Wiesław; Schleicher, Rosemary L.; Tsai, Wei Yann; Tu, Yi-Hsuan; Camann, David; Tang, Deliang; Perera, Frederica P.

doi:10.1093/ajcn/86.4.1139

Cited by 37 publications

(35 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We concluded that high efficiency of vitamin A transfer in our study, regardless of the low maternal serum vitamin A status could also manifest the effect of vitamin A on birth outcomes. Several reports have shown that cord vitamin A concentration is significantly correlated with neonatal head circumference (38,39,43). The relationship between maternal vitamin status and neonatal head circumference remains to be confirmed further.…”

Section: Effect Of Maternal Vitamin a Status On Birth Outcomesmentioning

confidence: 93%

“…Scholl et al (16) reported that at 28 wk, higher circulating concentrations of vitamin E were positively associated with several indicators of fetal growth. Masters et al (38) also reported that infants whose mothers had low plasma ␣-tocopherol concentrations (below the median) weighed 92.9 g less and had 0.41 cm smaller head circumference than did infants whose mothers had high ␣-tocopherol concentrations. Other studies reported that maternal vitamin E levels at gestation of 18 and 30 wk were not related to birth outcomes (47).…”

Section: Effect Of Maternal Vitamin C and Vitamin E Status On Birth Omentioning

confidence: 99%

“…Most indices of maternal vitamin status were not associated with birth outcomes measured in our study. The associations between levels of maternal serum vitamin A during pregnancy and birth outcomes have been examined by other investigators, who also found the positive relationship (18,38,39), but others did not (20). Several reports also have found a negative correlation between maternal vitamin A status and birth weight (40).…”

Section: Effect Of Maternal Vitamin a Status On Birth Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Summary Background: Emerging evidence indicates that maternal oxidative stress during pregnancy could impair fetal growth and that antioxidant vitamins (e.g. vitamins A, E and C) have a significant role in miantaining physiological processes of pregnancy and growth. Aims: To determine the concentrations of vitamins A, E, and C in pair-matched maternal and cord serum samples of neonate, and thus to investigate the relationship between maternal serum levels of these vitamins at delivery and birth outcomes. Methods: A total of 143 mother-neonate pairs were recruited into the cross-sectional descriptive study. Demographic information was investigated by questionnaire. After delivery, both cord and maternal blood were collected for quantification of serum levels of vitamins A, E and C by HPLC. Results: Maternal serum levels of vitamins A and E were significantly higher than those in cord serum. In contrast, vitamin C level in cord serum was significantly higher than that in maternal serum. Further, we found that maternal vitamin A status was significantly correlated to both birth weight ( r ϭ 0.19, p ϭ 0.0419) and birth height ( r ϭ 0.21, p ϭ 0.0311), and these were manifested by these findings: (i) per 250.2 g reduction in birth weight concomitant with 1 mol/L increase in maternal serum vitamin A level ( p Ͻ 0.01; 95% CI: 56.9-451.5); and (ii) per 1% increase in the ratio of serum vitamin A level of neonate to mother concomitant with 0.8 cm increase in birth height ( p ϭ 0.049; 95% CI: 0.004-1.639). Conclusion: Maternal vitamin A, but not vitamins E and C, during pregnancy had a significant effect on birth outcomes. Further studies are necessary to investigate the role of these antioxidant vitamins in fetal growth at various gestation stages.

show abstract

Section: Effect Of Maternal Vitamin a Status On Birth Outcomesmentioning

confidence: 93%

Section: Effect Of Maternal Vitamin C and Vitamin E Status On Birth Omentioning

confidence: 99%

Section: Effect Of Maternal Vitamin a Status On Birth Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…There are studies that suggest micronutrients have direct effects or may be markers of other underlying determinants of pregnancy outcomes [8]. It is known that vitamin A (retinol) is a lipid-soluble micronutrient required for normal mammalian reproduction and embryonic [9] and fetal development [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction

et al. 2009

View full text Add to dashboard Cite

IUGR (intrauterine growth restriction) increases the incidence of perinatal complications and, although several placental transport functions have been shown to be altered in pregnancies complicated by IUGR, the mechanism behind it is not well understood. The aim of the present study was to investigate factors in maternal and cord blood plasma from normal and IUGR-complicated pregnancies associated with the body weight of newborns. At the time of Caesarean section, 24 women with IUGR pregnancies were compared with a group of 30 normal controls with AGA (appropriate gestational age) fetuses who were studied at Caesarean section, which took place 5 weeks later than IUGR pregnancies, and also to a group of 25 non-delivered gestational age-matched control pregnant women (AGA-35wk). Maternal plasma retinol, gamma- and alpha-tocopherol, NEFAs (non-esterified fatty acids), and palmitic, palmitoleic, gamma-linolenic and arachidonic acids were higher in women with IUGR pregnancies than in AGA-35wk controls, whereas stearic and alpha-linolenic acids were lower. Smaller differences were found when comparing these variables for IUGR and AGA women. However, umbilical vein plasma gamma-tocopherol, cholesterol, triacylglycerols and NEFAs were higher in the IUGR group than in the AGA group, whereas arachidonic acid was lower. Maternal plasma retinol and NEFAs were the only variables negatively correlated with birthweight when multiple linear regressions were analysed. In conclusion, the increased levels of circulating retinol and NEFAs in maternal plasma are negatively associated with birth and placental weights, which may reflect an impaired placental transfer in IUGR pregnancies. As retinoids are involved in the control of gene transcription, it is proposed that a decrease in placental transfer of retinol could underlie the metabolic dysfunction of IUGR pregnancies.

show abstract

“…(Helzlsouer, 1989) The oxidative pathways connecting low lycopene to preterm birth and PPROM have not been fully studied, but have been linked by several investigators. (Luo et al, 2006;Masters et al, 2007) Lycopene has been linked to a decrease in preterm birth by Sharma et al, (2002) who entered 251 primagravida women in a prospective randomized control trial in the second trimester. One hundred sixteen women received lycopene (2mg twice daily) while 135 women received placebo (both until delivery).…”

Section: Preterm Birth/preterm Premature Rupture Of the Membranesmentioning

confidence: 99%

Oxidative Stress and Antioxidants: Preterm Birth and Preterm Infants

Knuppel¹,

Hassan²,

McDermott³

et al. 2012

Preterm Birth - Mother and Child

View full text Add to dashboard Cite

Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes

Abstract: Maternal alpha-tocopherol and cord retinol concentrations were significantly and positively associated with BW and HC. These micronutrients may have direct effects or may be markers for other underlying determinants of these pregnancy outcomes.

Cited by 37 publications

References 39 publications

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction

Oxidative Stress and Antioxidants: Preterm Birth and Preterm Infants

Contact Info

Product

Resources

About