Effect of smoking on tear proteins

Grus, Franz H.; Sabuncuo, P.; Augustin, Albert J.; Pfeiffer, Norbert

doi:10.1007/s00417-002-0539-y

Cited by 34 publications

(23 citation statements)

References 22 publications

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“…Chronic smokers were also reported to have low corneal and conjunctival sensitivity, 39 increased conjunctival squamous metaplasia, 39 and alteration of tear proteins. 7,41,42 In our previous study, we found tear film instability and abnormal lipid layer interferometry patterns in chronic smokers attributing these changes to a possible tear film lipid layer damage. 39 In accordance with studies on tear film stability changes in chronic smokers, we reconfirmed significant perturbation of the tear film stability in our current work.…”

mentioning

confidence: 81%

“…Fume particles and noxious gases such as nicotine and carbon monoxide may influence the circulatory system by inducing profound vasospasm, platelet aggregation, or leading to oxidative damage to lipids, proteins, and cellular DNA. [2][3][4][5][6][7][8] Epidemiological data link cigarette smoking as a risk factor for many ophthalmological disorders including strabismus in offspring of pregnant smokers, anterior ischaemic optic neuropathy, age related macular degeneration, cataract, thyroid ophthalmopathy, primary open angle glaucoma, diabetic retinopathy, uveal melanoma, conjunctival intraepithelial neoplasia, ocular sarcoidosis, and development of dry eyes. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] The Beaver Dam Study related current active smoking and past history of smoking to a higher prevalence of dry eye disease.…”

Section: Introductionmentioning

confidence: 99%

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Alterations of the tear film and ocular surface health in chronic smokers

Matsumoto

Doğru

Goto

et al. 2008

Eye

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Objective To investigate the effects of chronic smoking on ocular surface and tear functions. Methods Fifteen right eyes of 15 healthy chronic smokers (9 men, 6 women; age range: 36-47 years) who smoked 20 cigarettes per day for 20 years and 20 eyes of 20 control nonsmokers (12 men, 8 women; age range: 38-43 years) were included in this prospective study. All subjects underwent measurements of breath and haemoglobin CO concentration, tear lipid layer interferometry, evaporimetry, tear film break-up time (TBUT), Schirmer's I test, corneal fluorescein staining, conjunctival impression, and brush cytology. Results The mean Hb CO level was significantly higher in smokers compared to non-smokers. TBUT was also significantly shorter in smokers. Tear lipid layer showed significant slowing in spread over the tear film with a concomitant significant increase in tear evaporation rate. Conjunctival impression cytology revealed significant loss of goblet cells and squamous metaplasia in smokers. Brush cytology showed significant conjunctival neutrophil infiltration in smoker subjects. Conclusion Chronic smoking induced distinctive quantitative and qualitative disturbances on the ocular surface health.

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mentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Alterations of the tear film and ocular surface health in chronic smokers

Matsumoto

Doğru

Goto

et al. 2008

Eye

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“…Significant changes in the proteomic pattern of dry eye patient tears compared to those of healthy subjects have been reported by several authors [7][8][9][10][11] and were also documented for contact lens wearers [12,13]. However the development of ocular dryness in contact lens wearers seems to be influenced by certain factors like female sex, smoking, use of video display terminals and age [14,15]. Moreover the type of contact lens cleaning solution seems to play an important role.…”

Section: Introductionmentioning

confidence: 74%

Longitudinal analysis of taurine induced effects on the tear proteome of contact lens wearers and dry eye patients using a RP-RP-Capillary-HPLC–MALDI TOF/TOF MS approach

Funke

Azimi

Wolters

et al. 2012

Journal of Proteomics

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“…Smoking also affects tear secretion and protein components in tears [5,6]. Furthermore, cigarette smoking may be harmful to the corneal endothelium.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2015

AOVS

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We compared the biomechanical properties of corneas in eyes of healthy chronic smokers and non-smokers. In this prospective, comparative, and cross-sectional study, 50 eyes of 50 healthy chronic smokers (Study group) and 50 eyes of 50 agematched, healthy non-smokers (Control group) were enrolled. The corneal hysteresis (CH) and corneal resistance factor (CRF) were measured intwo groups using the Ocular Response Analyzer (ORA). Differences in the corneal biomechanical properties were determined using an independent-samples t test. Urine samples were collected to measure urinary levels of cotinine. Correlations between the number of cigarettes smoked per day, smoking duration, age, and CH-CRF values in the smokers group were also evaluated. Mean CH was 10.63±2.08 (SD) mmHg and 10.57±1.45 mmHg and the mean CRF was 10.53±1.81 mmHg and 10.27±1.77 mmHg in the smoker and control groups, respectively (p>0.05). CH and CRF were not correlated with the number of cigarettes smoked per day, smoking duration, or age. The findings indicate that cigarette smoking does not affect corneal biomechanical parameters such as CH and CRF. In addition, CH and CRF are not affected by the number of cigarettes smoked per day, smoking duration, or age. Keywords 2/4 Results and Discussion Demographic FindingsIn this study, 50 eyes of 50 healthy chronic smokers admitted to our department were included. As a control group, 50 eyes of 50 age-matched, healthy non-smokers were included. The mean ± SD age of the included subjects was 36.28±5.91 years (range 28-48) and 35.02±5.83 years (range 27-49 years) for the smokers group and the non-smokers group, respectively (p ˃0.05). On average, smokers smoked 16.70±8.00 (range 10-30) cigarettes per day and had been smoking for 12.20±3.01 (range 10-20) years.). The characteristics of the two groups of subjects are shown in (Table 1). There were no statistically significant differences between the two groups with regard to gender, AL, and CCT distributions (p˃0.05).Cotinine levels in the urine were 44.2±9.8 ng/ml in nonsmokers and 2439±451 ng/ml in smokers (p˂0.05). These data clearly indicate that the smokers were accurately selected, because the urine cotinine concentration in nonsmokers is normally below 500 ng/ml [14]. Biomechanical Parameters (CH and CRF) Urinary Cotinine ConcentrationTo distinguish objectively between smokers and nonsmokers, it was necessary to determine the level of cotinine in the urine. Cotinine, the major metabolite of nicotine, has a half life of 24 hours and is readily detectable in the smoker's urine even several days after the smoker has terminated smoking. Urine samples were collected in clean plastic containers to measure urinary levels of cotinine [11], and the basic technique used was based on spectrophotometric assessment at wavelength 532 nm. Laboratory workups were performed in the laboratory of the Kanuni Sultan Suleyman Education and Research Hospital. The influence of diuresis on urinary cotinine concentrations was corrected using the method described by T...

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Effect of smoking on tear proteins

Cited by 34 publications

References 22 publications

Alterations of the tear film and ocular surface health in chronic smokers

Alterations of the tear film and ocular surface health in chronic smokers

Longitudinal analysis of taurine induced effects on the tear proteome of contact lens wearers and dry eye patients using a RP-RP-Capillary-HPLC–MALDI TOF/TOF MS approach

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