Effect of Smoking on Pharmacokinetics of Clopidogrel, an Antiplatelet Drug

Abstract

p = 0.041, respectively). p = 0.012). Smoking behavior had no influence on Cmax (p = 0.16),. In general, the pharmacokinetic parameters were characterized by considerable coefficient of variation (CV) = 37.9 %), (Tmax = 1.71 ± 1.15 h, CV = 67.2 %), CV = 36.7 %) and (t1/2e = 4.57 ± 3.15 h, CV = 68.9 %). Conclusion: Smoking behavior may not be a significant determinant of the pharmacokinetics of clopidogrel following oral administration of 600 mg dose in patients undergoing PCI.