Effect of Sm2O3 substitution on mechanical and biological properties of 45S5 bioactive glass

Ershad,; Vyas, Vikas Kumar; Prasad, S. K.; Ali, Akher; Pyare, Ram

doi:10.1007/s41779-018-0190-7

Cited by 17 publications

(9 citation statements)

References 31 publications

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“…Even for these two cases, it is possible to attain a better evolution at longer testing intervals. Overall, the LIVE/DEAD assay confirms the beneficial influence of Sm on the cells development in simulating conditions, as it was also reported by other researchers [ 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Resultssupporting

confidence: 87%

“…The glasses with Sm content (maximum 2 mol% Sm 2 O 3 ) showed improved osteoblastic behavior and antibacterial effects, dependent on the amount of Sm in the composition [ 32 ]. Ershad et al [ 33 ] studied melt-derived bioactive glasses with up to 4 wt.% Sm 2 O 3 ; they found that nucleation and crystal growth temperature decrease, while bioactivity and mechanical properties improve with Sm 2 O 3 concentration increasing. Sm-doped thin films were prepared from the desire to ensure two key features contributing to a better outcome following bone graft implantation: rapid osseointegration and infection avoidance; the tests evidenced antifungal properties, simultaneously with lack of toxicity against regular cell lines for Sm contents below 1 mol% [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route

et al. 2021

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Three different inorganic scaffolds were obtained starting from the oxide system SiO2‒P2O5‒CaO‒MgO, to which Ce4+/Sm3+/Sr2+ cations were added in order to propose novel materials with potential application in the field of hard tissue engineering. Knowing the beneficial effects of each element, improved features in terms of mechanical properties, antibacterial activity and cellular response are expected. The compositions were processed in the form of scaffolds by a common sol-gel method, followed by a thermal treatment at 1000 and 1200 °C. The obtained samples were characterized from thermal, compositional, morphological and mechanical point of view. It was shown that each supplementary component triggers the modification of the crystalline phase composition, as well as microstructural details. Moreover, the shrinkage behavior is well correlated with the attained compression strength values. Sm was proven to be the best choice, since in addition to a superior mechanical resistance, a clear beneficial influence on the viability of 3T3 fibroblast cell line was observed.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route

et al. 2021

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“…Baranowska et al [ 96 ] used the luminescent properties (at 601 and 648 nm) of bioactive 45S5 BG fibers doped with Sm 3+ to investigate the degradation behavior of the fibers. Furthermore, in vitro formation of apatite-like structures on Sm-BG substrates was observed after incubation in SBF by Ershad et al [ 97 ]. The authors found that adding Sm 2 O 3 to BGs up to a concentration of 3 wt.% increased the formation of hydroxycarbonate-apatite (HCA) layer on the surface after 21 days.…”

Section: Rare Earth Elements-containing Bioactive Glassesmentioning

confidence: 99%

“…Furthermore, Sm-BGs exhibited enhanced mechanical properties. Young’s modulus (76.36–78.89 GPa), shear modulus (30.25–31.95 GPa), and bulk modulus of Sm-containing 45S5 BGs increased with increasing concentration of Sm 2 O 3 [ 97 ]. Poisson’s ratio, on the other hand, decreased as the concentration of Sm 2 O 3 increased.…”

Section: Rare Earth Elements-containing Bioactive Glassesmentioning

confidence: 99%

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Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Bioactive ZnO‐assisted 1393 glass scaffold promotes osteogenic differentiation: Some studies

et al. 2022

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We developed ZnO‐assisted 1393 bioactive glass‐based scaffold with suitable mechanical properties through foam replica technique and observed to be suitable for bone tissue engineering application. However, the developed scaffolds' ability to facilitate cellular infiltration and integration was further assessed through in vivo studies in suitable animal model. Herein, the pure 1393 bioactive glass (BG) and ZnO‐assisted 1393 bioactive glass‐ (ZnBGs; 1, 2, 4 mol% ZnO substitution for SiO2 in pure BG is named as Z1BG, Z2BG, Z3BG, respectively) based scaffolds were prepared through sol–gel route, followed by foam replica techniques and characterized by a series of in vitro and some in vivo tests. Different cell lines like normal mouse embryonic cells (NIH/3T3), mouse bone marrow stromal cells (mBMSc), peripheral blood mononuclear cells, that is, lymphocytes and monocytes (PBMC) and U2OS (carcinogenic human osteosarcoma cells) were used in determination and comparative analysis of the biological compatibility of the BG and ZnBGs. Also, the alkaline phosphatase (ALP) activity, and osteogenic gene expression by primer‐specific osteopontin (OPN), osteocalcin (OCN), and glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) genes were performed to study osteogenic differentiability of the stromal cells in different BGs. Moreover, radiological and histopathological tests were performed in bone defect model of Wister rats to evaluate the in vivo bone regeneration and healing. Interestingly, these studies demonstrate augmented biological compatibility, and superior osteogenic differentiation in ZnBGs, in particular Z3BG than the pure BG in most cases.

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Effect of Sm2O3 substitution on mechanical and biological properties of 45S5 bioactive glass

Cited by 17 publications

References 31 publications

Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route

Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Bioactive ZnO‐assisted 1393 glass scaffold promotes osteogenic differentiation: Some studies

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