Effect of Sleeve Gastrectomy Plus Side-to-Side Jejunoileal Anastomosis for Type 2 Diabetes Control in an Obese Rat Model

Wang, Kaijing; Zhou, Xiao-Gang; Quach, Giang; Lu, Jiajun; Gao, Wei; Xu, Anan; Zhu, Jinxia

doi:10.1007/s11695-015-1811-7

Cited by 7 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The db/db mouse has a dysfunctional leptin receptor that leads to obesity and insulin resistance. SG does not lead to sustained weight loss in mice deficient in leptin signaling (11)(12)(13)(14)(15), but we observed improved glycemic control even after mice had surpassed their presurgical weight and when compared with pair-fed mice. The improvement was reflected mainly in increased peripheral hepatic insulin sensitivity and not in b-cell recovery and was characterized by hepatic regulation of peroxisome proliferator-activated receptor-a (PPARa) and hepatocyte nuclear factor-a (HNF4a) target genes.…”

contrasting

confidence: 53%

“…Studies comparing nonobese patients and murine models who had lost weight after bariatric surgery or food restriction have identified weight-independent effects of surgery (10,(31)(32)(33). Rodents deficient in leptin signaling are hyperphagic and have been shown by us and others to gain weight after surgery, highlighting the importance of leptin in weight loss after SG (11)(12)(13)(14)(15)(34)(35)(36). Moreover, these models decouple surgical effects from weight loss while keeping experimental groups obese.…”

Section: Discussionmentioning

confidence: 99%

“…4B and C). In addition, 14 C-2-deoxyglucose tracing demonstrated that skeletal muscle but not epididymal adipose tissue was more insulin sensitive in SG-operated mice (Fig. 4D).…”

Section: Sg Increases Insulin Sensitivity Compared With Pair-fed Micementioning

confidence: 91%

See 2 more Smart Citations

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

et al. 2018

View full text Add to dashboard Cite

Bariatric surgery dramatically improves glycemic control, yet the underlying molecular mechanisms remain controversial because of confounding weight loss. We performed sleeve gastrectomy (SG) on obese and diabetic leptin receptor-deficient mice (/). One week postsurgery, mice weighed 5% less and displayed improved glycemia compared with sham-operated controls, and islets from SG mice displayed reduced expression of diabetes markers. One month postsurgery SG mice weighed more than preoperatively but remained near-euglycemic and displayed reduced hepatic lipid droplets. Pair feeding of SG and sham / mice showed that surgery rather than weight loss was responsible for reduced glycemia after SG. Although insulin secretion profiles from islets of sham and SG mice were indistinguishable, clamp studies revealed that SG causes a dramatic improvement in muscle and hepatic insulin sensitivity accompanied by hepatic regulation of hepatocyte nuclear factor-α and peroxisome proliferator-activated receptor-α targets. We conclude that long-term weight loss after SG requires leptin signaling. Nevertheless, SG elicits a remarkable improvement in glycemia through insulin sensitization independent of reduced feeding and weight loss.

show abstract

contrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A meta-analysis including 16 RCT with a total of 1,132 patients revealed that the RYGB procedure was more effective than SG in terms of weight loss and short-term glycemic control in patients with and without T2D [21]. Wang et al [22] compared the effects of the RYGB and SG procedures in ZDF rats and found that the RYGB group had a greater weight loss than the SG group every week and better glucose control 5 weeks after the operation. Our observational findings in animal models further support the previous conclusions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study

et al. 2021

View full text Add to dashboard Cite

Background: While bariatric surgery could result in weight loss as well as glycaemia improvement, the short-term impact on bone health in a high glycemic environment following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) remains intriguing. Objective: The aim of this study was to compare the short-term effects of RYGB and SG procedures on bone health in Zucker diabetic fatty (ZDFfa/fa) rats. Methods: Thirty age-matched male ZDFfa/fa rats were randomized into RYGB, SG, and sham groups after establishment of the diabetic model. Body weight, blood glucose, bone mineral density (BMD), the level of bone turnover markers (BTM), vitamin D, and serum calcium and phosphorus were measured 4 weeks after the operation. Results: The RYGB procedure brought about lower blood glucose, BMD, serum calcium and phosphorus levels, as well as a relatively higher bone turnover rate and 1,25(OH)2VD level, compared to the SG and sham groups, while the influences of the SG procedure were not significant. 25(OH)VD demonstrated no significant difference among the 3 groups. Conclusions: Despite its excellent ability to provide short-term glycemic control, the RYGB procedure could led to more severe impairment of bone health compared to the SG procedure. Bone health should be procured after bariatric surgery, especially with the RYGB procedure. Early detection of BMD and BTM may help to avoid deterioration of bone.

show abstract

“…To improve LSG's success, an additional intestinal bypass surgery combined with traditional SG (Sleeve Gasrectomy) side to side with jejunoileal anastomosis (JI-SG) has recently been examined and revealed favorable results in weight loss and enhancement of T2DM remission rate [23,24]. These two combined surgeries (JI-SG) comprise two physiological changes: the first is the exclusion of the gastric body and fundus of the stomach, which declines stomach capacity [25], and the second is side-to-side anastomosis of the ileum and jejunum, which transfers food more rapidly into the terminal ileum, without excluding or resecting any segments of the digestive tract. Based on the hindgut theory, this process of accelerating nutrient delivery to the hindgut produces better glycemic control [26].…”

Section: Different Types Of Surgeriesmentioning

confidence: 99%

Resolving of diabetes mellitus post laparoscopic sleeve gastrectomy

Arrowaili¹

2017

IJMDC

View full text Add to dashboard Cite

The prevalence of type 2 diabetes mellitus (T2DM) is increasing globally with obesity as a risk factor for T2DM. Non-surgical and surgical methods are used to treat morbid obesity. Laparoscopic Sleeve Gastrectomy (LSG) is being recognized as an effective independent procedure for treating morbidly obese patients with T2DM by removing the gastric fundus and transforming the stomach into a narrow gastric tube. This paper discusses effects of LSG in T2DM resolution and remission, and its short-term and long-term influence on obese patients with T2DM with making comparison with other types of surgeries to resolve T2DM. LSG seems to have a substantial beneficial influence on T2DM, producing resolution in the majority of patients included in the studies. LSG has gained popularity for its relative operative ease and lower risk profile.

show abstract

Effect of Sleeve Gastrectomy Plus Side-to-Side Jejunoileal Anastomosis for Type 2 Diabetes Control in an Obese Rat Model

Abstract: JI-SG induced higher ghrelin and GLP-1 levels and improved glycemic control in Zucker diabetic fatty rats. Compared with SG and RYGB, JI-SG appeared to be a simple, relatively safe, and more effective procedure for treating type 2 diabetes and obesity in this animal model.

Cited by 7 publications

References 30 publications

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study

Resolving of diabetes mellitus post laparoscopic sleeve gastrectomy

Contact Info

Product

Resources

About