Effect of six different peri‐implantitis disinfection methods on <i>in vivo</i> human oral biofilm

Gosau, Martin; Hahnel, Sebastian; Schwarz, Frank; Gerlach, Till; Reichert, Torsten E.; Bürgers, Ralf

doi:10.1111/j.1600-0501.2009.01908.x

Cited by 131 publications

(141 citation statements)

References 59 publications

(133 reference statements)

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“…For the treatment of peri-implant diseases, oral hygiene instructions should be undertaken in order to enhance oral hygiene of natural teeth and dental implants. 40 Unfortunately, studies on treatment options for peri-implant diseases are generally limited in number, with small sample sizes and short follow up periods. 41 However, clinical data must be interpreted from controlled and randomized studies, with big sample size.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Karimi¹,

Hasani²,

Khosroshahian

2016

J Lasers Med Sci

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Introduction:The purpose of the present study was to assess the clinical effects of antimicrobial photodynamic therapy (PDT) after closed surface scaling in the treatment of peri-implant diseases. Methods: Ten patients with a total of 15 pairs of dental implants, showing clinical and radiographic signs of peri-implant diseases, were included in this study. In each patient, one implant randomly served as control implant and the other served as test implant. The control implants were treated with closed surface scaling only and the test implants received additionally PDT, using light with a wavelength of 630 nm and intensity of 2000 mw/cm 2 for 120 seconds after application of photosensitizer in peri-implant sulcus. Clinical parameters were evaluated before and 1.5 and 3 months after treatment. Results: Statistical analysis showed significant differences in probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and gingival index (GI) at each time point between the two groups. There were no statistically significant changes with respect to any of the parameters in the control group. Complete resolution of BOP at 3 months was achieved in 100% of test implants. At 1.5 and 3 months, there were significant differences in the mean probing depth and CAL gain measurements at implants in the test group. Conclusion: The present study revealed that adjunctive use of PDT following closed surface scaling could lead to clinical improvement of peri-implant diseases. Further studies are necessary to confirm our results. Keywords: clinical trial; dental implant; mechanical debridement; peri-implantitis; photodynamic therapy Please cite this article as follows: Karimi MR, Hasani A, Khosroshahian S. Efficacy of antimicrobial photodynamic therapy as an adjunctive to mechanical debridement in the treatment of peri-implant diseases: a randomized controlled clinical trial.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Karimi¹,

Hasani²,

Khosroshahian

2016

J Lasers Med Sci

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“…So far, this variable has not been evaluated, with studies found in which the volunteers did not brush their teeth at all [50,51], while there are others in which they did [7–9,52,53]. Our results revealed that the thickness of the SF-biofilm formed after 48 h and its bacterial viability were significantly affected by the toothbrushing protocol, as these microscopic parameters were higher in test 1 (without toothbrushing), especially in the medial-mesial positions.…”

Section: Discussionmentioning

confidence: 99%

In situ substrate-formed biofilms using IDODS mimic supragingival tooth-formed biofilms

Tomás

Prada-López

Quintas

et al. 2018

Journal of Oral Microbiology

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This study aimed to compare the bacterial viability and diversity of a substrate-formed biofilm (SF-biofilm) in situ to a supragingival tooth-formed biofilm (TF-biofilm) in the same group of individuals. The impact of the device/disc position and toothbrushing during the formation of SF-biofilm was also assessed. Two tests were run. In test 1, 15 volunteers wore two hemi-splints carrying six discs of human enamel, glass, and hydroxyapatite for 2 days, and were instructed to not perform any oral hygiene measure. Biofilm samples were collected from the substrates and the contralateral tooth and were analysed using CLSM. In five volunteers, half of the biofilm present on the discs and their contralateral teeth were scraped and analysed using 16S pyrosequencing. In test 2, the microscopic analysis was repeated only on the SF-biofilm samples, and the volunteers were allowed to brush their teeth. Multivariate analyses revealed that the donors had a significant effect on the composition of the biofilm, confirming its subject-dependent character. The bacterial composition of the SF-biofilm was similar to the TF-biofilm, with significant differential abundance detected in very few taxa of low abundance. The toothbrushing during the formation of SF-biofilm was the only factor that conditioned the thickness or bacterial viability.

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“…Using this model, we have generated realistic biofilms on dental implants in 48 h and then used these to test the effectiveness of various debridement methods. Other groups have likewise developed methods for developing dental plaque on implants using in situ appliances [102][103][104], and this will likely be a productive approach for future studies. A particular advantage of our own system is that it can use both a flat titanium disc and an actual commercial titanium implant, whereas other models use flat titanium discs.…”

Section: In Situ Modelsmentioning

confidence: 99%

Novel Models to Manage Biofilms on Microtextured Dental Implant Surfaces

Tran¹,

Walsh²

2016

Microbial Biofilms - Importance and Applications

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Dental implants are used extensively to replace missing teeth. To enhance their integration with the bones of the jaws, the surfaces of titanium dental implants are modified to make them hydrophilic, high energy, and microtextured. These same features make biofilm development occur readily upon exposure to the saliva. The presence of mature biofilms on dental implant surfaces drives local inflammatory responses in the adjacent soft and hard tissues (peri-implantitis), which leads to pathological loss of bone and the formation of a saucer shaped bone defects. This chapter examines the unique challenges posed by biofilms formed on highly complex dental implant surfaces, which are difficult to access for cleaning, and easily damaged by conventional cleaning approaches. We explore how biofilms can be removed from implant surfaces using a variety of novel methods, without causing surface damage or other undesirable modifications, and show how different laboratory and clinical models can be used to assess the performance of both conventional and novel methods of biofilm removal.

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Effect of six different peri‐implantitis disinfection methods on in vivo human oral biofilm

Abstract: All tested antiseptics seem to be able to reduce the total amount of microorganisms accumulating on titanium surfaces. Furthermore, sodium hypochlorite, hydrogen peroxide, chlorhexidine, and Listerine showed a significant bactericidal effect against adhering bacteria.

Cited by 131 publications

References 59 publications

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

In situ substrate-formed biofilms using IDODS mimic supragingival tooth-formed biofilms

Novel Models to Manage Biofilms on Microtextured Dental Implant Surfaces

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