Effect of Single Administration of Coffee on Pupil Size and Ocular Wavefront Aberration Measurements in Healthy Subjects

Bardak, Handan; Günay, Murat; Mumcu, Uğur; Bardak, Yavuz

doi:10.1155/2016/9578308

Cited by 14 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future research into the relationship between fatigue and PNS activation could use both HRV and pupillometry indices of SNS and PNS activation, and assess both the effects of task-evoked and daily-life fatigue [ 63 ]. Furthermore, the processes driving the PLR may be even more complex, as recent work in the fields of neuroscience and psychology has shown it to be affected by visual attention and higher-level processing [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pupil light reflex evoked by light-emitting diode and computer screen: Methodology and association with need for recovery in daily life

Wang

Zekveld²,

Wendt

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

ObjectivesPupil light reflex (PLR) has been widely used as a method for evaluating parasympathetic activity. The first aim of the present study is to develop a PLR measurement using a computer screen set-up and compare its results with the PLR generated by a more conventional setup using light-emitting diode (LED). The parasympathetic nervous system, which is known to control the ‘rest and digest’ response of the human body, is considered to be associated with daily life fatigue. However, only few studies have attempted to test the relationship between self-reported daily fatigue and physiological measurement of the parasympathetic nervous system. Therefore, the second aim of this study was to investigate the relationship between daily-life fatigue, assessed using the Need for Recovery scale, and parasympathetic activity, as indicated by the PLR parameters.DesignA pilot study was conducted first to develop a PLR measurement set-up using a computer screen. PLRs evoked by light stimuli with different characteristics were recorded to confirm the influence of light intensity, flash duration, and color on the PLRs evoked by the system. In the subsequent experimental study, we recorded the PLR of 25 adult participants to light flashes generated by the screen set-up as well as by a conventional LED set-up. PLR parameters relating to parasympathetic and sympathetic activity were calculated from the pupil responses. We tested the split-half reliability across two consecutive blocks of trials, and the relationships between the parameters of PLRs evoked by the two set-ups. Participants rated their need for recovery prior to the PLR recordings.ResultsPLR parameters acquired in the screen and LED set-ups showed good reliability for amplitude related parameters. The PLRs evoked by both set-ups were consistent, but showed systematic differences in absolute values of all parameters. Additionally, higher need for recovery was associated with faster and larger constriction of the PLR.ConclusionsThis study assessed the PLR generated by a computer screen and the PLR generated by a LED. The good reliability within set-ups and the consistency between the PLRs evoked by the set-ups indicate that both systems provides a valid way to evoke the PLR. A higher need for recovery was associated with faster and larger constricting PLRs, suggesting increased levels of parasympathetic nervous system activity in people experiencing higher levels of need for recovery on a daily basis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…All participants visited the lab for a two-hour experiment. Participants were asked not to drink coffee on the same day before the experiment, as the effect of caffeine on the pupil response remains unclear [ 62 , 63 ]. The NfR was completed by the participant shortly after he or she had arrived.…”

Section: Methodsmentioning

confidence: 99%

Pupil light reflex evoked by light-emitting diode and computer screen: Methodology and association with need for recovery in daily life

Wang

Zekveld²,

Wendt

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In our study, we also instructed our study subjects to abstain from alcohol, caffeine and nicotine for a period of at least four hours prior to testing. Minimal data is available on which to base potential duration of effect of these agents on pupil function, though there is data to suggest that caffeine effects on pupil function begin to resolve by four hours (30,31), nicotine effects within 20 minutes (32), and alcohol with effects on pupil size that resolve with signs of intoxication (33). In alert subjects, dark-adapted pupil size has been shown to have minimal day-to-day variability, without the need to control for sleep, diet or activity levels (34), and remains stable for up to six months in individuals up to 47 years of age (35,36).…”

Section: Discussionmentioning

confidence: 99%

Altered pupillary light response scales with disease severity in migrainous photophobia

et al. 2017

View full text Add to dashboard Cite

Background Autonomic dysfunction and light sensitivity are core features of the migraine attack. Growing evidence also suggests changes in these parameters between attacks. Though sensory and autonomic responses likely interact, they have not been studied together across the spectrum of disease in migraine. Methods We performed digital infrared pupillometry while collecting interictal photophobia thresholds (PPT) in 36 migraineurs (14 episodic; 12 chronic; 10 probable) and 24 age and sex-matched non-headache controls. Quantitative pupillary light reflexes (PLR) were assessed in a subset of subjects, allowing distinction of sympathetic vs parasympathetic pupillary function. A structured questionnaire was used to ascertain migraine diagnosis, headache severity, and affective symptoms. Results Photophobia thresholds were significantly lower in migraineurs than controls, and were lowest in chronic migraine, consistent with a disease-related gradient. Lower PPT correlated with smaller dark-adapted pupil size and larger end pupil size at PPT, which corresponded to a reduced diameter change. On PLR testing, measures of both parasympathetic constriction and sympathetic re-dilation were reduced in migraineurs with clinically severe migraine. Conclusions In summary, we show that severity of photophobia in migraine scales with disease severity, in association with shifts in pupillary light responses. These alterations suggest centrally mediated autonomic adaptations to chronic light sensitivity.

show abstract

“…The effects of coffee on IOP, 9 choroidal thickness, 10 pupillary response, 11 ocular perfusion, 5 and macular degeneration 12 have been widely assessed in previous studies, however no study so far has investigated the association of coffee intake with AL, ACD, AD, and LT. In this study, we aimed to evaluate the potential acute changes in the ocular biometric measurements after ingestion of a cup of coffee.…”

Section: Introductionmentioning

confidence: 99%

The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

Uzun

Aslan

Öter

et al. 2019

Journal of Current Ophthalmology

View full text Add to dashboard Cite

PurposeTo evaluate ocular biometric changes in healthy subjects after caffeine consumption from a cup of coffee.MethodsA total of 36 subjects were included in this prospective observational study. Axial length (AL) and anterior segment parameters including aqueous depth (AD), anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT) were measured with optic biometry, Lenstar LS 900 (Haag-Streit, Inc., Koeniz, Switzerland) before and 1 and 4 h after ingesting a cup of coffee (60 mg caffeine/100 mL).ResultsMean age of the participants was 30.05 ± 7.43 years (range, 19–45). At baseline, 1st, and 4th hour, AL values were 23.9 ± 1.04 mm, 23.91 ± 1.04 mm, and 23.89 ± 1.04 mm, respectively, and no significant difference was observed (P>0.05). At baseline, 1st, and 4th hour, AD values were 3.06 ± 0.3 mm, 3.11 ± 0.3 mm, and 3.09 ± 0.3 mm, and ACD values were 3.6 ± 0.32, 3.66 ± 0.31, and 3.64 ± 0.31, respectively. AD and ACD values were significantly greater than baseline at 1st and 4th hours following coffee ingestion. Coffee intake caused a significant reduction in LT, compared with baseline and at the 1st and 4th hours which were 3.76 ± 0.28 mm, 3.69 ± 0.32 mm, and 3.72 ± 0.27 mm, respectively. No statistically significant difference was determined in between the 3 measurements in terms of CCT (P>0.05).ConclusionCaffeine causes a significant increase in AD and ACD and a significant decrease in LT following oral intake, for at least 4 h.

show abstract

Effect of Single Administration of Coffee on Pupil Size and Ocular Wavefront Aberration Measurements in Healthy Subjects

Cited by 14 publications

References 25 publications

Pupil light reflex evoked by light-emitting diode and computer screen: Methodology and association with need for recovery in daily life

Pupil light reflex evoked by light-emitting diode and computer screen: Methodology and association with need for recovery in daily life

Altered pupillary light response scales with disease severity in migrainous photophobia

The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

Contact Info

Product

Resources

About