Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin‐rich extracts

Corona, Giulia; Coman, Maria Magdalena; Guo, Yuxuan; Hotchkiss, Sarah; Gill, Chris; Yaqoob, Parveen; Spencer, Jeremy P. E.; Rowland, Ian

doi:10.1002/mnfr.201700223

Cited by 56 publications

(49 citation statements)

References 54 publications

(111 reference statements)

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“…Seaweeds are rich in phenolic compounds with varied bioactive properties [46,47]. Rajauria et al [48] identified and characterized eight phenolic compounds from brown Irish seaweed Himanthalia elongate, which exhibited strong antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

Sustainable Agronomic Strategies for Enhancing the Yield and Nutritional Quality of Wild Tomato, Solanum Lycopersicum (l) Var Cerasiforme Mill

et al. 2019

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Urbanization and global climate change have constrained plant development and yield. Utilization of wild gene pool, together with the application of sustainable and eco-friendly agronomic crop improvement strategies, is being focused on to tackle mounting food insecurity issues. In this aspect, the green seaweed, Ulva flexuosa, was assessed for plant biostimulant potential on cherry tomato, in terms of seed priming effects, nutrition and yield. SEM-EDX analysis of U. flexuosa presented the occurrence of cell wall elements (O, Na, Mg, S, Cl, K and Ca). The phytochemical analyses of liquid seaweed extract (EF-LSE) revealed the presence of carbohydrates, protein, phenols, flavonoids, saponins, tannins and coumarins. The EF-LSEs were found to stimulate seed germination in a dose-dependent manner, recording higher seed germination, and biomass and growth parameters. The seedlings of treated seeds altered the biochemical profile of the fruit, in terms of TSS (93%), phenol (92%), lycopene (12%) and ascorbic acid (86.8%). The EF-LSEs positively influenced fruit yield (97%). Henceforth, this investigation brings to light the plant biostimulant potential of the under-utilized seaweed source, U. flexuosa, to be useful as a bio fertilizer in agronomic fields for a cumulative enhancement of crop vigour as well as yields to meet the growing food demands.

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Section: Discussionmentioning

confidence: 99%

Sustainable Agronomic Strategies for Enhancing the Yield and Nutritional Quality of Wild Tomato, Solanum Lycopersicum (l) Var Cerasiforme Mill

et al. 2019

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“…Another study separated the small (< 2 kDa) phlorotannins from Ascophyllum nodosum on a C18 column into two distinct peaks using diode array detector (DAD) . However, separation and identification of phlorotannins by HPLC fitted with a DAD is complicated even further by the lack of standards available for comparison . Whilst DAD detection can be useful for analysis of compounds with similar molecular weights but different electronic distribution in the chromophore, leading to different UV spectra, standards or literature data are needed for comparison if the compounds are to be identified.…”

Section: Liquid Chromatography Of Phlorotannins and Hyphenated Technimentioning

confidence: 99%

A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds

Ford

Theodoridou

Sheldrake

et al. 2019

Phytochemical Analysis

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IntroductionPhlorotannins, the phenolic compounds found in brown seaweeds, are a unique and diverse class of compounds showing a huge potential for food and pharmaceutical applications.ObjectiveThis review will give an account of the colorimetric assays used and a discussion of their quantitative and qualitative analytical shortcomings. It will also discuss other more complex and modern analytical chemistry methods that are currently being developed to study phlorotannins. The purpose of this review is to increase awareness of these bioactive compounds and promote further development of robust analytical methods for use in biology, food science, pharmacology and biomedical and cosmeceutical sciences.ResultsWhilst the biological activity and huge commercial potential of the phlorotannins has been widely reported throughout the literature, the chemical structures and reactivity of these compounds is still not well understood. The phlorotannin content of seaweed is usually characterised using colorimetric assays. However, although these methods give a reasonable overall estimation of the total phenolic content, they lack precision and specificity.ConclusionThis review highlights the strengths and weaknesses of commonly used colorimetric assays. Novel techniques are highlighted using more selective chemistry to identify this class of compounds.

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“…Several reports indicated that polyphenolic compounds extracted from natural materials including plants have anti-genotoxic properties (Corona et al, 2017;Surh & Ferguson, 2003;Williams, Dashwood, Hendricks, & Bailey, 1989). These reports indicated that the polyphenolic components scavenge free radicals from the cells and consequently protect the cellular systems from oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity of Nitraria retusa leaf extracts against mitomycin C-induced genetic toxicity in male mice

Khalil

Ahmed

Kassem

et al. 2019

JoBAZ

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Background: Recently, a great interest in the usage of new derived drugs extracted from plant has been increased to treat and/or prevent several diseases including cancer. Therefore, the present study was conducted to use Nitraria retusa leaf extract to increase the antioxidant activity and reduce the genotoxic activity of chemotherapeutic drugs mitomycin C (MMC) in male mice. Male Swiss albino mice (n = 80) were divided in several experimental groups and treated with single dose of MMC with supplementation of 50 and 100 mg/kg body wt Nitraria retusa leaf extract for several time intervals (3 days, 1 week, and 1 month). Results: This study found that MMC-treated mice observed significant increases in the frequency of chromosomal abnormalities in both cell types including bone marrow and spermatocyte cells, induce the mean values of DNA damage, and decrease the expression values of antioxidant enzyme-related genes (CAT, GPx, and GSTT1) compared with control mice. However, supplementation of MMC-treated mice with Nitraria retusa leaf extract suppressed the harmful impacts induced by MMC especially with the high dose and longer duration of the administration. Conclusion: The results suggested that the protective capacity of the Nitraria retusa leaf extract in protecting the hepatic cells could be attributed to the presence of isorhamnetin 3-o-robinobioside, palmitic acid, and β-sitosterols in its extract which are known for their anti-tumor and anti-mutagenic activities.

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Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin‐rich extracts

Cited by 56 publications

References 54 publications

Sustainable Agronomic Strategies for Enhancing the Yield and Nutritional Quality of Wild Tomato, Solanum Lycopersicum (l) Var Cerasiforme Mill

Sustainable Agronomic Strategies for Enhancing the Yield and Nutritional Quality of Wild Tomato, Solanum Lycopersicum (l) Var Cerasiforme Mill

A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds

Antioxidant capacity of Nitraria retusa leaf extracts against mitomycin C-induced genetic toxicity in male mice

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