Effect of silymarin on gluconeogenesis and lactate production in exercising rats

Choi, Eun‐Ju; Kim, Min Jung; Jeoung, Nam Ho; Kim, Sang-Hyun

doi:10.1007/s10068-016-0108-5

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…However, the use of SM as an ergogenic in exercise-training models is limited. Choi et al [ 17 ] determined the effect of SM on gluconeogenesis during exercise in rats and found that, after four weeks of exercise training that included running on a treadmill, the administration of SM (50 mg/kg) may improve the gluconeogenesis and β-oxidation induced by exercise training, reducing lactate and triglyceride serum levels, reducing the expression of Akt, phosphoenolpyruvate carboxykinase (PEPCK), and the peroxisome proliferator-activated receptor-γ (PPARγ) in the liver; in muscle, the expression of AMP-activated kinase (AMPK) was low and the expression of pyruvate dehydrogenase kinase 4 (PDK4) was favored. The relevance of these findings lies in that the enzyme PEPCK is involved in the first-rate limiting step of AMPK, and these are also engaged in fatty acid oxidation and gluconeogenesis and PDK4 in mitochondrial glucose oxidation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Vargas-Mendoza

Ángeles-Valencia

Madrigal-Santillán

et al. 2020

IJMS

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(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.

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Section: Discussionmentioning

confidence: 99%

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Vargas-Mendoza

Ángeles-Valencia

Madrigal-Santillán

et al. 2020

IJMS

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“…Many clinical trials have been conducted to prove the effectiveness of silymarin or its flavonolignans in several medical disorders; however, information on the effects of physical exercise is very scarce. Previously, one study reported that the administration of silymarin (50 mg/kg) may improve the metabolism of glucose, lactate, and lipids during exercise by interfering with the expression of the genes involved in gluconeogenesis, β-oxidation, and glucose oxidation in a 4-week treadmill running protocol in rats [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model

Vargas-Mendoza

Ángeles-Valencia

Morales-González

et al. 2021

JFMK

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Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

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“…3 -Hydroxy 3 -Coenzyme Methyl Glutaryl A is a speed-limiting enzyme reductase in CHO biosynthesis (32). Using the same mechanism, statin drugs are used to lower CHO (33).…”

Section: Discussionmentioning

confidence: 99%

The effect of aerobic training with silymarin consumption on some cardiovascular risk factors in men with type 2 diabetes

2020

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Background and objective: Type 2 diabetes (T2D) is a metabolic disease that leads to increased levels of lipids, therefore the present study aimed to investigate the effect of eight weeks of aerobic training(AT) with silymarin (S)consumption on lipid profile in men with type 2 diabetes. Methods: 60 middle-aged male volunteers were randomly divided into 4 groups, including: (1) control(C) + placebo, (2) AT + placebo, (3) S consumption and (4) AT+S consumption. The AT groups performed for eight weeks, three sessions per week and 20-45 minutes per session at an intensity of 60 to 85% of the reserve heart rate, and the S groups of consumed 140 mg / kg of S daily (in two meals). Serum levels of Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Cholesterol (CHO), and Triglyceride (TG) were measured before and after the test. Data were analyzed using one-way ANOVA and Bonferroni's test, and P value less than 0.05 was considered significant. Results: AT reduced serum levels of LDL, CHO, TG and increased HDL in men with T2D(P ≥ 0.05). Consumption of S reduced LDL, CHO, TG and increased HDL in men with T2D(P ≥ 0.05). AT and S consumption reduced LDL, CHO, TG and increased HDL; also, decrease in LDL, CHO, TG and increase in HDL in the AT and S consumption group was more favorable than the effect of S alone (P ≥ 0.05). Conclusion: It seems that AT and S consumption simultaneously have interactive effects on reducing LDL, CHO, TG and increasing HDL in men with T2D.

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Effect of silymarin on gluconeogenesis and lactate production in exercising rats

Cited by 9 publications

References 31 publications

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model

The effect of aerobic training with silymarin consumption on some cardiovascular risk factors in men with type 2 diabetes

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