Effect of side chain structure on the liquid crystalline properties of polymers bearing cholesterol, dihydrocholesterol and bile acid pendant groups

Limitations extractives des ingrédients fonctionnels natifs : lipides bioactifs par modifications chimiques

“…Dans un tout autre domaine, de telles structures stéroliques créées synthétiquement [34][35][36][37][38] se sont également révélé posséder des proprié-tés particulièrement intéressantes pour la formation de cristaux liquides ou d'agrégats moléculaires [39] ; notamment à travers l'acquisition de nouvelles propriétés optiques non linéaires obtenues par hydroxysubstitution de dérivés azo-benzéniques avec des esters de cholestérol [40] (figure 5). La capacité de ces molécules bioactives à modifier leur structure a conditionné leur utilisation dans le contrôle photochimique des changements de phases, dans la formation de dispositifs de mémoire optique ou de conducteurs unidimensionnels et photoconducteurs, etc.…”

Novel tri- and tetrafunctional cholic acid-based initiators for the synthesis of star-shaped poly(L-lactide)s

“…42, 3.83, 3.95 ppm for 1b). Furthermore, the 13 C NMR spectrum of compound 3b showed seven carbon signals between 170.7 and 179.2 ppm pertinent to seven Co groups confirming the acylation of all three hydroxyl groups of CA methyl ester by succinic anhydride. Similar considerations can be made for confirming the structure of compound 3a.…”

“…The polyacidic compounds 3a-b were treated with thionyl chloride affording the corresponding acyl chlorides 4a-b which, in turn, were reacted with ethylene glycol to give the final cholic acid-based initiators 2a-b which were fully characterized by 1 H, 13 C NMR and mass spectrometry. NMR, so we used the size exclusion chromatography (SEC) technique to obtain these data.…”

“…[2][3][4] This easily available and low-cost chemical, thanks to its intrinsic biodegradability, biocompatibility and renewability combined with the easy modifiability of the hydroxyl and carboxyl groups and the stability of steroid skeleton, was chosen by many researchers to design and synthesize new cholic acid-containing oligomeric or polymeric materials. [5,6] Various types of such polymers were produced in the last two decades: in several of these, the CAs were part of the main chain, [7][8][9][10] while in others, the CAs were connected as pendants [11][12][13] or, more recently, as the core of star-shaped polymers. [14][15][16][17][18][19] New star-shaped polymers have attracted the attention of scientists for many years in virtue of their unique physicochemical properties.…”

Synthesis of Terpene-Based Polymers

“…PEG-cholic acid derived monomer (low content) has been copolymerized with NIPAM (high content) to give a water-soluble copolymer responding to temperature, salt, and pH when COOH groups in cholic acid moieties are liberated [219]. Differing from the polymer formed by Chol-based methacrylates, polymers with bile acid pendant groups do not form any LC structure [220]. Nevertheless, they show great potential as matrix material for mineralization of biominerals [221].…”