Effect of Si and Fe doping on calcium phosphate glass fibre reinforced polycaprolactone bone analogous composites

Mohammadi, Maziar Shah; Ahmed, Ifty; Muja, Naser; Almeida, S.; Rudd, C.D.; Bureau, Martin; Nazhat, Showan N.

doi:10.1016/j.actbio.2011.12.030

Cited by 31 publications

(28 citation statements)

References 39 publications

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“…In this study, MG63 cells cultured on Mg coated and non-coated fibre reinforced composites showed no significant difference in terms of cell metabolic activity (Figure 8), proliferation (Figure 9), differentiation ( Figure 10) or cell attachment, morphology and spreading ( Figure 11). Cells demonstrated usual functions; attachment, metabolism and differentiation were comparable to the results reported by Mohammadi et al 39 and Jiang et al 17 The similarities observed from the cell culture studies for the Mg coated and non-coated composite samples is expected, in that the cell interaction was primarily with the PCL surface of the composite. Therefore, the only variation to be expected would be from the ions leached into the culture medium from the Mg coated and non-coated glass fibres.…”

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confidence: 84%

“…This further suggested that the glass fibre degradation process had been inhibited due to the magnesium coating, which correlated well with the weight loss profiles observed. Mohammadi et al 39 investigated 50% P 2 O 5 -40% CaO-(10-x)% SiO 2 -x% Fe 2 O 3 (x ¼ 0, 5 and 10) phosphate glass reinforced PCL composites and also suggested that the ion release behaviour of these composites was dominated by the degradation of the phosphate glass. Glass fibres with higher degradation rates resulted in higher ion release profiles.…”

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confidence: 99%

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Mechanical, degradation and cytocompatibility properties of magnesium coated phosphate glass fibre reinforced polycaprolactone composites

et al. 2014

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Retention of mechanical properties of phosphate glass fibre reinforced degradable polyesters such as polycaprolactone and polylactic acid in aqueous media has been shown to be strongly influenced by the integrity of the fibre/polymer interface. A previous study utilising 'single fibre' fragmentation tests found that coating with magnesium improved the fibre and matrix interfacial shear strength. Therefore, the aim of this study was to investigate the effects of a magnesium coating on the manufacture and characterisation of a random chopped fibre reinforced polycaprolactone composite. Short chopped strand non-woven phosphate glass fibre mats were sputter coated with degradable magnesium to manufacture phosphate glass fibre/polycaprolactone composites. The degradation behaviour (water uptake, mass loss and pH change of the media) of these polycaprolactone composites as well as of pure polycaprolactone was investigated in phosphate buffered saline. The Mg coated fibre reinforced composites revealed less water uptake and mass loss during degradation compared to the non-coated composites. The cations released were also explored and a lower ion release profile for all three cations investigated (namely Na(+), Mg(2+) and Ca(2+)) was seen for the Mg coated composite samples. An increase of 17% in tensile strength and 47% in tensile modulus was obtained for the Mg coated composite samples. Both flexural and tensile properties were investigated and a higher retention of mechanical properties was obtained for the Mg coated fibre reinforced composite samples up to 10 days immersion in PBS. Cytocompatibility study showed both composite samples (coated and non-coated) had good cytocompatibility with human osteosarcoma cell line.

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confidence: 99%

Mechanical, degradation and cytocompatibility properties of magnesium coated phosphate glass fibre reinforced polycaprolactone composites

et al. 2014

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“…The poly(β-caprolactone) composites can be to be used as bone analogous materials in applications such as bone fracture fixation devices or, in the case of a porous structure, scaffolds for bone tissue engineering [6].…”

Section: Methodsmentioning

confidence: 99%

“…Calcium phosphate has been the subject of many studies in the last decade because of it biocompatibility, ability to fill bone cavities and properties which are desirable for surgical applications. The synthesis of nanocrystalline calcium hydroxyapatites for the fabrication of composite materials as bone graft substitutes is a critical issue in bioceramic research [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Doped calcium carbonate-phosphate used for bone tissue technology

Koroleva¹,

Dobrinskaya²,

Каманцев³

2017

Intergr Clin Med

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Doped with K + , Mg 2+ , Fe 2+ , Zn 2+ , Mn 2+ , Li + , Au 3+ , SiO 2 nanocrystalline calcium carbonate-phosphate extends significantly the functionality for drug delivery: it can be used to speed up the processes of bone repair and bone tissue strengthening. The advantage over other calcium phosphate biomaterials is strengthening of bone and tooth tissues of a human being of any age, the substances being transported through skin to restore broken bones in a critically short period of time regardless of age. The mechanical fracture strength of bone tissue increases almost in 5 times. These studies suggest doped calcium carbonate-phosphate is the most appropriate material, because reduce of the cholesterol rate in the blood in 2-2.5 time. The best results have been observed with concentrations of 5-10% doped calcium carbonatephosphate in the implant used the polycaprolactone. Young`s modulus is maximal for specimens with 5% doped calcium carbonate-phosphate.

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“…It was previously shown that the smaller particles of bioactive glass, incorporated into poly(e-caprolactone-co-DL-lactide) matrix, significantly enhanced the water absorption compared to larger particles, resulting in faster loss of polymer molecular weight [9]. In the literature, there are several works indicating that the chemical composition of resorbable phosphate glasses significantly affects degradation of PCL matrix [31,51]. Phosphate glass fillers, depending on formulation, dissolve in different rate, creating voids and channels within the polymer matrix, affecting water absorption, and therefore polymer degradation.…”

Section: In Vitro Degradationmentioning

confidence: 99%

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

et al. 2017

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In the present work, the role of content, size and chemical composition of gel-derived bioactive glass particles from the SiO 2 -CaO-P 2 O 5 system in modulating the in vitro bioactivity, osteoinductive properties and long-term (up to 15 months) degradation behaviour of poly(e-caprolactone)-based composite films was investigated. Bioactivity was assessed in simulated body fluid (SBF) and HEPES-free Dulbecco's modified Eagle medium (DMEM) supplemented with 10% foetal bovine serum (FBS), while hydrolytic degradation tests were performed in phosphate buffer saline. Obtained composite films showed excellent calcium phosphate (CaP) layer forming ability in both SBF and DMEM-10% FBS. However, kinetics of bioactivity process strongly depended on the type of medium used. The layer of amino acids and proteins, derived from cell culture medium, on the surfaces of composites created barrier that inhibited release of the ions on the one hand, while increasing nucleation density of calcium phosphates, affecting the morphology of formed CaP layers on the other. The presence of bioactive glass fillers was shown to impart osteoinductive properties to obtained films, supporting osteoblast attachment and proliferation, as well as stimulating cell differentiation and also matrix mineralization process in vitro. We showed that kinetics of bioactivity process and also osteoinductive properties of composite films could be easily modulated with the use of different contents and chemical compositions of fillers. The results showed that modification of PCL matrix with bioactive glass particles accelerated its degradation. We proved that the degradation rate of composites could be controlled and optimized for bone regeneration, in particular by using bioactive fillers causing different calcium phosphate layer forming ability on the surfaces of composites, depending on particle size and chemical composition. We have presented new opportunities to design and obtain multifunctional composites with tunable degradation and bioactivity kinetics, as well as biological properties that can meet complex requirements of bone tissue engineering.

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Effect of Si and Fe doping on calcium phosphate glass fibre reinforced polycaprolactone bone analogous composites

Cited by 31 publications

References 39 publications

Mechanical, degradation and cytocompatibility properties of magnesium coated phosphate glass fibre reinforced polycaprolactone composites

Mechanical, degradation and cytocompatibility properties of magnesium coated phosphate glass fibre reinforced polycaprolactone composites

Doped calcium carbonate-phosphate used for bone tissue technology

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

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