Effect of shorter dark adaptation on ISCEV standard DA 0.01 and DA 3 skin ERGs in healthy adults

Hamilton, Ruth; Graham, Kathryn

doi:10.1007/s10633-016-9554-x

Cited by 18 publications

(17 citation statements)

References 23 publications

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“…We did not find increased intersubject amplitude variability with the 10-min adaptation, which is also consistent with the study by Hamilton and Graham [2]. Although there is a statistically significant effect of adaptation duration on peak time, it does not appear clinically relevant if one considers the interindividual variability.…”

Section: Discussionsupporting

confidence: 92%

“…For instance, with 10 min of DA, the amplitude was reduced by 10% and peak times were slightly shorter. Asakawa et al [3] have recently extended this (also using skin electrodes) to cone responses and pupillography, and for the dark-adapted responses found highly similar effects as Hamilton and Graham [2].…”

Section: Introductionmentioning

confidence: 77%

“…While potentially interesting for research questions, the additional benefits of a systematic electrophysiological assessment of the complete time course in clinical routine testing by means of the ERG are not obvious, especially when taking the additional effort into account. However, as pointed out by Hamilton and Graham [2], it might be feasible to increase the diagnostic utility of the ERG by identifying a DA duration where responses show a greater difference between healthy and diseased eyes. Such an approach could possibly also achieve a better differentiation between different pathologies that yield indiscriminable ERG results with 20 min of DA.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Hamilton and Graham [2] have addressed this void and assessed the effect of reduced DA, testing a series of different durations down to 1 min. They found no sizable effect on the ISCEV DA 3.0 response, while the DA 0.01 was markedly reduced in amplitude and peak time with short adaptation durations.…”

Section: Introductionmentioning

confidence: 99%

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ERG shrinks by 10% when reducing dark adaptation time to 10 min, but only for weak flashes

2020

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Purpose To compare dark-adapted (DA) ERG between 10, 15 and 20 min of dark adaptation (DA). Methods In a counterbalanced random block design, 40 healthy adult subjects were dark-adapted for 10, 15 or 20 min before we recorded ERGs to nine flash strengths from 0.001 to 10.0 cd s/m 2 (dilated pupils) with a DTL-like electrode. Before and between sessions, the room was lit. Apart from choosing a wider range of stimulus strengths, and adding shorter DA times, the recordings fully complied with the ISCEV ERG Standard, namely using corneal electrodes, mydriasis and a standard DA sequence. Results The a-wave amplitude was not affected by any adaptation condition. For the b-wave amplitude, effects of reduced DA time are stronger for weaker flashes: Reducing DA from 20 to 10 min had no measurable effect on the DA 3 ERG, but reduced the DA 0.01 b-wave significantly (p \ 0.0001) to 87 ± 2% (mean ± SEM). The DA 0.001 b-wave (not part of the ISCEV ERG Standard) was more affected (down to 72 ± 4%). There was a small, but significant, increase, only for weak flashes, in a-and b-wave peak times for 20 compared to 10-min dark adaptation time. Conclusion Reducing dark adaptation time from 20 to 10 min in normal participants has no effect on the ISCEV DA 3 and DA 10 ERG. The reduction in DA 0.01 ERGs to 87 ± 2% agrees with Hamilton and

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ERG shrinks by 10% when reducing dark adaptation time to 10 min, but only for weak flashes

2020

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“…Inclusion criteria were refractive errors of < 3 dioptres, and a normal Ishihara colour test result. The sample size was selected to power a concomitant study of shorter dark adaptation for ISCEV standard DA ERGs [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Dark-adapted red flash ERGs in healthy adults

Hamilton

Graham

2018

Doc Ophthalmol

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PurposeThe x-wave of the dark-adapted (DA) ERG to a red flash reflects DA cone function. This exploratory study of healthy adults aimed to investigate changes in the DA red ERG with flash strength and during dark adaptation to optimise visualisation and therefore quantification of the x-wave.MethodsThe effect of altering red flash strength was investigated in four subjects by recording ERGs after 20 min dark adaptation to red flashes (0.2–2.0 cd s m−2) using skin electrodes and natural pupils. The effect of dark adaptation duration was investigated in 16 subjects during 20 min in the dark, by recording DA 1.5 red ERGs at 1, 2, 3, 4, 5, 10, 15 and 20 min.ResultsFor a dark adaption period of 20 min, the x-wave was more clearly visualised to weaker (< 0.6 cd s m−2) red flash strengths: to stronger flashes it became obscured by the b-wave. For red flashes of 1.5 cd s m−2, the x-wave was most prominent in ERGs recorded after 1–5 min of dark adaptation: with longer dark adaptation, it was subsumed into the b-wave’s rising edge.ConclusionsThis small study suggests that x-wave visibility in healthy subjects after 20 min dark adaptation is improved by using flashes weaker than around 0.6 cd s m−2; for flash strengths of 1.5 cd s m−2, x-wave visibility is enhanced by recording after only around 5 min of dark adaptation. No evidence was found that interim red flash ERGs affect the dark-adapted state of the normal retina.

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Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording

et al. 2018

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Effect of shorter dark adaptation on ISCEV standard DA 0.01 and DA 3 skin ERGs in healthy adults

Abstract: Reducing dark adaptation from 20 to 10 min or even less has an effect on only DA 0.01 ERGs. Shorter dark adaptation than 20 min may not compromise the clinical utility of the ERG providing clinics adhere to the usual standards of adequate reference data.

Cited by 18 publications

References 23 publications

ERG shrinks by 10% when reducing dark adaptation time to 10 min, but only for weak flashes

ERG shrinks by 10% when reducing dark adaptation time to 10 min, but only for weak flashes

Dark-adapted red flash ERGs in healthy adults

Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording

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