Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording

Ross, Maya; Honig, Hen; Ezra-Elia, Raaya; Banin, Eyal; Obolensky, Alexey; Averbukh, Edward; Rosov, Alexander; Gootwine, E.; Ofri, Ron

doi:10.1007/s10633-018-9661-y

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…These different findings may be partly due to the fact that electrophysiological tests are subject to the variability introduced by technical factors, such as device type, hardware configuration, electrodes, positioning, flash features, test with different number of stimuli arrays, or clusters analyzed (rings or quadrants). Physiological factors-such as pupil dilation or even temperature and oxygenation-can also introduce variability [54]. It should likewise be noted that the studies conducted include patients with different subtypes of the disease and with or without optic neuritis (see Table 3).…”

Section: Discussionmentioning

confidence: 99%

Empirical Mode Decomposition-Based Filter Applied to Multifocal Electroretinograms in Multiple Sclerosis Diagnosis

Santiago

Castillo

García‐Martín

et al. 2019

Sensors

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As multiple sclerosis (MS) usually affects the visual pathway, visual electrophysiological tests can be used to diagnose it. The objective of this paper is to research methods for processing multifocal electroretinogram (mfERG) recordings to improve the capacity to diagnose MS. MfERG recordings from 15 early-stage MS patients without a history of optic neuritis and from 6 control subjects were examined. A normative database was built from the control subject signals. The mfERG recordings were filtered using empirical mode decomposition (EMD). The correlation with the signals in a normative database was used as the classification feature. Using EMD-based filtering and performance correlation, the mean area under the curve (AUC) value was 0.90. The greatest discriminant capacity was obtained in ring 4 and in the inferior nasal quadrant (AUC values of 0.96 and 0.94, respectively). Our results suggest that the combination of filtering mfERG recordings using EMD and calculating the correlation with a normative database would make mfERG waveform analysis applicable to assessment of multiple sclerosis in early-stage patients. Author Contributions: Conceptualization, E.G.-M., M.J.R., E.M.S.M., and L.B.; methodology, L.d.S., M.O.d.C., C.C., J.M.M., A.L., and B.C.; software, L.d.S., M.O.d.C., C.C., J.M.M., and A.L.; validation, L.d.S., M.O.d.C., C.C., J.M.M., and A.L.; formal Analysis, M.O.d.C. and J.M.M.; investigation, E.G.-M., M.J.R., E.M.S.M., and L.B.; resources, L.B. and E.G.-M.; data Curation, L.d.S., M.O.d.C., C.C., J.M.M., A.L., and B.C.; writing-original draft preparation, L.B., E.G.-M., and M.J.R.; writing-review and editing, L.B., E.G.-M., and M.J.R.; visualization, L.B. and E.G.-M.; supervision, L.B. and E.G.-M.; project administration, L.B. and E.G.-M.; funding acquisition, L.B. and E.G.-M. All authors have read and agreed to the published version of the manuscript.

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Section: Discussionmentioning

confidence: 99%

Empirical Mode Decomposition-Based Filter Applied to Multifocal Electroretinograms in Multiple Sclerosis Diagnosis

Santiago

Castillo

García‐Martín

et al. 2019

Sensors

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“…For scotopic ERG test, the animals were dark-adapted for 12 h and for the PhNR protocol light adaptation to a blue background, and red Light Emitting Diode flash was used as stimulus. Both eyes’ pupils were fully dilated with mydriatic eye drops for bilateral simultaneous testing 30 . Electrode impedance discrepancy < 2 kΩ between electrodes was accepted.…”

Section: Methodsmentioning

confidence: 99%

Tunable degrees of neurodegeneration in rats based on microsphere-induced models of chronic glaucoma

Rodrigo

Bravo‐Osuna

Subías

et al. 2022

Sci Rep

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This study compares four different animal models of chronic glaucoma against normal aging over 6 months. Chronic glaucoma was induced in 138 Long–Evans rats and compared against 43 aged-matched healthy rats. Twenty-five rats received episcleral vein sclerosis injections (EPIm cohort) while the rest were injected in the eye anterior chamber with a suspension of biodegradable microspheres: 25 rats received non-loaded microspheres (N-L Ms cohort), 45 rats received microspheres loaded with dexamethasone (MsDexa cohort), and 43 rats received microspheres co-loaded with dexamethasone and fibronectin (MsDexaFibro cohort). Intraocular pressure, neuroretinal function, structure and vitreous interface were evaluated. Each model caused different trends in intraocular pressure, produced specific retinal damage and vitreous signals. The steepest and strongest increase in intraocular pressure was seen in the EPIm cohort and microspheres models were more progressive. The EPIm cohort presented the highest vitreous intensity and percentage loss in the ganglion cell layer, the MsDexa cohort presented the greatest loss in the retinal nerve fiber layer, and the MsDexaFibro cohort presented the greatest loss in total retinal thickness. Function decreased differently among cohorts. Using biodegradable microspheres models it is possible to generate tuned neurodegeneration. These results support the multifactorial nature of glaucoma based on several noxa.

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Comparative analysis of electroretinogram with subdermal and invasive recording methods in mice

Liu

Yuan

Xiang

2023

Biochemical and Biophysical Research Communications

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Consecutive unilateral recording of the two eyes affects dark-adapted ERG responses, when compared to simultaneous bilateral recording

Cited by 5 publications

References 42 publications

Empirical Mode Decomposition-Based Filter Applied to Multifocal Electroretinograms in Multiple Sclerosis Diagnosis

Empirical Mode Decomposition-Based Filter Applied to Multifocal Electroretinograms in Multiple Sclerosis Diagnosis

Tunable degrees of neurodegeneration in rats based on microsphere-induced models of chronic glaucoma

Comparative analysis of electroretinogram with subdermal and invasive recording methods in mice

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