Effect of short‐term propofol administration on pancreatic enzymes and lipid biochemistry in children between 1 month and 36 months

Abstract

We conclude that despite a small, transient increase in serum triglycerides and pancreatic enzymes, short-term propofol administration in recommended dosages in children of ASA status I and II aged between 1 month and 36 months does not produce any clinically significant effect on serum lipids and pancreatic enzymes.

Acute pancreatitis associated with intravenous administration of propofol: evaluation of causality in a systematic review of the literature

“…The duration of propofol administration and its total dose were quite different in these studies. Moreover, these studies did not report in detail the AP diagnosis according to ACG criteria and thus did not meet the eligibility criteria set for this review except for one case from one study [18]. We could not draw definite conclusion from these studies.…”

Confounding Factors Associated With Propofol-Induced Acute Pancreatitis: A Review

“…11 These previous reports suggest that the administration of propofol increases triglycerides, cholesterol, and lipase, all within normal ranges. 6,10,11 Furthermore, these increased levels of triglycerides, amylase, and lipase induced by propofol did not produce acute pancreatitis, which meets the criteria of acute pancreatitis suggested by the American College of Gastroenterology. 6,10,12,13 However, the incidence of hypertriglyceridemia (400 mg/dL) and the median time to cause hypertriglyceridemia in patients taking continuous propofol infusion for mechanical ventilation in intensive care units were reported to be 27.9% (38/136) and 47 hours (16.3–73.5), respectively.…”

“…6,10,11 Furthermore, these increased levels of triglycerides, amylase, and lipase induced by propofol did not produce acute pancreatitis, which meets the criteria of acute pancreatitis suggested by the American College of Gastroenterology. 6,10,12,13 However, the incidence of hypertriglyceridemia (400 mg/dL) and the median time to cause hypertriglyceridemia in patients taking continuous propofol infusion for mechanical ventilation in intensive care units were reported to be 27.9% (38/136) and 47 hours (16.3–73.5), respectively. 14 The only risk factor responsible for propofol-induced hypertriglyceridemia (400 mg/dL) was cumulative dose of propofol, and the incidence of pancreatitis in patients with propofol-induced hypertriglyceridemia was 5.3% (2/38).…”

“…9 Short-term infusion (59 6 21.51 minutes) of propofol increased serum triglyceride and lipase in children, but stayed within the normal limit, but did not produce any clinical sign of acute pancreatitis. 10 Propofol used for sedation in adults older than 90 years, undergoing endoscopic procedures, did not develop pancreatitis. 8 Propofol anesthesia increased triglyceride and cholesterol compared with baseline, which is within normal limits, but did not significantly change amylase.…”

“…Propofol is dissolved in 10% Intralipid (100% long-chain triglyceride), which suggests that propofol-induced acute pancreatitis is associated with hypertriglyceridemia 4,5 Propofol increases triglyceride, cholesterol, and lipase, which are still within normal limits, but did not cause acute pancreatitis. 6–11 However, there are some clinical case reports suggesting that propofol could cause acute pancreatitis (Tables 1 and 2). To the best of our knowledge, there are no studies that examine the factors responsible for this discrepancy between several case reports (Tables 1 and 2) and research (clinical and laboratory).…”