Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney

Jung, Kyung Jin; Lee, E. K.; Kim, J. Y.; Zou, Yang; Sung, Bokyung; Heo, Hyoung-Sam; Kim, M. K.; Lee, J.; Kim, N. D.; Yu, Bo; Chung, Hae Young

doi:10.1007/s00011-008-7227-2

Cited by 109 publications

(76 citation statements)

References 29 publications

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“…Our finding that short-term CR was as effective as longterm CR is important for several reasons, not the least of which is that if clinical therapy is to be designed on the basis of CR, it would be difficult for patients to comply with CR for life, but would be much more feasible if the therapy could be instituted in old patients, already afflicted with the adverse effects of aging. Other studies have noted that gene changes and vascular changes of aging can be effective with CR instituted in older animals (Jung et al 2009;Rippe et al 2010), but this is the first study to show that functional effects of aging on a major organ, i.e., aging cardiomyopathy can be completely rescued by CR after the cardiomyopathy developed. Another novel finding is that, although CR protects against cardiac apoptosis (Fig.…”

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confidence: 76%

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

Yan

Gao

et al. 2013

AGE

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Calorie restriction (CR) is the most widely studied intervention protecting from the adverse effects of aging. Almost all prior studies have examined the effects of CR initiated in young animals. Studies examining the effects of CR on development of aging cardiomyopathy found only partial prevention. The major goal of this study was to determine whether CR initiated after aging cardiomyopathy developed could reverse the cardiomyopathy. Aging cardiomyopathy in 2-year-old mice was characterized by reduced left ventricular (LV) function, cardiac hypertrophy, and increased cardiac apoptosis and fibrosis. When short-term (2 months) CR was initiated after aging cardiomyopathy developed in 20-month-old mice, the decrease in cardiac function, and increases in LV weight, myocardial fibrosis and apoptosis were reversed, such that the aging hearts in these mice were indistinguishable from those of young mice or mice where CR was initiated in young mice. If apoptosis was the mechanism for protecting against aging cardiomyopathy, then total myocyte numbers should have reverted to normal with CR, but did not. However, the alterations in cytoskeletal proteins, which contribute to aging cardiomyopathy, were no longer observed with CR. This is the first study to demonstrate complete prevention of aging cardiomyopathy by CR and, more importantly, that instituting this intervention even later in life can rapidly correct aging cardiomyopathy, which could have important therapeutic implications.

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confidence: 76%

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

Yan

Gao

et al. 2013

AGE

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“…These effects are mediated by a wide spectrum of biochemical and cellular adaptations, including redox homeostasis, mitochondrial function [80] , inflamma tion [81,82] , apoptosis [83] , and autophagy [84] . Oxidative stress plays an important role in the pathogenesis of coronary artery disease by mediating expression of inflammatory genes and eliciting oxidative modification of lipoprotein particles [85,86] .…”

Section: Signal Transduction Mechanism Involved In Crmentioning

confidence: 99%

“…Table 1 summaries some of the most important signaling molecules involved in CR-induced biological and physiological responses. FOXO ↓ [89,97] GSK-3β ↓ [93,98] HIF-1 ↓ [95,99] HSF-1 ↑ [94] HSP-70 ↑ [94,100] mTOR ↓ [90,101] NF-κB ↓ [81,82,95,97] PGC-1α ↑ [91,92] PPAR α ↑ [91,102] SIRT1 ↑↓ [92,93,103] ↑=increase in signal transduction; ↓=decrease in signal transduction.…”

Section: Signal Transduction Mechanism Involved In Crmentioning

confidence: 99%

Caloric restriction and heart function: is there a sensible link?

Han

Ren

2010

Acta Pharmacol Sin

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Calorie restriction (CR) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. In general, the daily caloric intake subjected to CR has been restricted to 50% to 70% of the average food intake in subjects eating ad libitum [1,2] . CR was first reported to retard aging and prolong median and maximal life span in the 1930s [3] . Over the last several decades, CR has been widely studied which exhibits an apparent beneficial impact on longevity, ageassociated diseases, and attenuation of functional decline, across a broad variety of species (including rats, mice, fish, flies, worms and yeast) [4,5] . Moreover, CR provides protection against a cadre of chronic diseases including diabetes mellitus, neurodegenerative diseases, autoimmune disorders [6][7][8] and cancer [9][10][11][12] . CR has been shown to alter a variety of physiological parameters especially reduced metabolic rate and oxidative damage, resulting in a decrease in the incidence of cardiovascular diseases [13] . In response to energy deficiency, experimental animals experience a drastic decrease in both fat mass and lean body mass. Muscle mass is overtly reduced, although the rate of loss of function and mass/body weight with the aging process is attenuated [9,[14][15][16] . Metabolic rate may decrease transiently although studies have indicated similar metabolic rate per kg lean body mass to that of ad libitum fed rodents in longterm CR protocol [17] . Body temperature, systolic and diastolic blood pressure all decrease [18,19] along with the reduced sympathetic activity [20] . CR-treated animals are more spontaneously active and display superior cognitive abilities compared to their ad libitum counterparts [21,22] .The most prominent mechanism that may be responsible for the beneficial health and physiological effects of CR are usually mediated through increased insulin sensitivity which results in reduced plasma glucose and insulin concentrations and improved glucose tolerance [23] ; reduced levels of oxidative stress (decreased oxidative damage to proteins, lipids and DNA) [24] , increased resistance to various types of stress including heat, oxidative and metabolic stress [25] as well as enhanced immune function [26] . Impact of CR on agingAn inverse relationship between calorie intake and lifespan has been revealed in mice, suggesting a key role for regulators of energy metabolism in the mechanism of CR. Accordingly, CR-induced metabolic reprogramming may be a key event in the mechanism of lifespan extension [27,28] . The age when CR is started, the severity of restriction, and strain or genetic background of animals determine the magnitude of life extension. The only mammals in which CR has clearly been shown ReviewCaloric restriction and heart function: is there a sensible link? Calorie restriction (CR) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. Ample of clinical and experimental evidence has demonstrated that CR is capable of retarding aging p...

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“…A few studies have reduced the intake by a fixed number of calories rather than a percentage of the regular intake. CR is typically instituted for a period of 6-12 months and longer [9]; however some studies have also investigated short term CR lasting up to 10 days [10].…”

Section: Introductionmentioning

confidence: 99%

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

Jain

Singh

2014

Ind J Clin Biochem

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L-carnitine is popular as a potential ergogenic aid because of its role in the conversion of fat into energy. The present study was undertaken to investigate the effect of short term supplementation of L-carnitine on metabolic markers and physical efficiency tests under short term calorie restriction. Male albino rats were divided into four groups (n = 12 in each)-control, calorie restricted (CR for 5 days, 25 % of basal food intake), L-carnitine supplemented (CAR, given orally for 5 days at a dose of 100 mg/kg), CR with L-carnitine supplementation (CR ? CAR). Food intake and body weight of the rats were measured along with biochemical variables like blood glucose, tissue glycogen, plasma and muscle protein and enzymatic activities of CPT-1 (carnitine palmitoyl transferase-1) and AMP kinase. Results demonstrated that Lcarnitine caused marked increase in muscle glycogen, plasma protein, CPT-1 activity and swim time of rats (P \ 0.05) on short term supplementation. In addition to the substantive effects caused by CR alone, L-carnitine under CR significantly affected muscle glycogen, plasma protein, CPT-1 activity and AMP kinase (P \ 0.05). Short term CR along with L-carnitine also resulted in increased swim time of rats than control, CR and L-carnitine treated rats (P \ 0.05). The present study was an attempt towards developing an approach for better adherence to dietary restriction regimen, with the use of L-carnitine.

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Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney

Abstract: We report for the first time that 10-day CR can attenuate the altered signaling transduction for inflammatory processes which is mediated through RS-induced NF-kB and AP-1 in aged kidney.

Cited by 109 publications

References 29 publications

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

Caloric restriction and heart function: is there a sensible link?

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

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