Effect of Short-Term Acclimatization to High Altitude on Sleep and Nocturnal Breathing

Nussbaumer-Ochsner, Yvonne; Ursprung, Justyna; Siebenmann, Christoph; Maggiorini, Marco; Bloch, Konrad E.

doi:10.5665/sleep.1708

Cited by 124 publications

(99 citation statements)

References 21 publications

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“…Fuji about 2.5-fold (Table 2), which is consistent with the findings of previous studies (Bartsch et al, 2004;Luks, 2012). It is plausible that sleeping at higher altitudes causes hypoxemia, and several studies have found that hypoxemia is associated with AMS (Erba et al, 2004;Koehle et al, 2010;Nespoulet et al, 2012;Nussbaumer-Ochsner et al, 2012). Recently, we reported that arterial oxygen saturation gradually decreased when sleeping overnight at a high altitude, ca.…”

Section: Effect Of Sleeping Altitudesupporting

confidence: 90%

Impact of Sleeping Altitude on Symptoms of Acute Mountain Sickness on Mt. Fuji

Horiuchi

Uno

Endo

et al. 2018

High Altitude Medicine & Biology

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Horiuchi, Masahiro, Tadashi Uno, Junko Endo, Yoko Handa, and Tatsuya Hasegawa. Impact of sleeping altitude on symptoms of acute mountain sickness on Mt. Fuji. High Alt Med Biol. 19:193-200, 2018. Aims: We sought to investigate the factors influencing acute mountain sickness (AMS) on Mt. Fuji in Japan, in particular, to assess the effects of sleeping altitude, by means of a questionnaire survey. This study involved 1932 participants who climbed Mt. Fuji, and obtained information regarding sex, age, and whether participants stayed at the mountain lodges. The AMS survey excluded the perceived sleep difficulties assessed with the Lake Louise Scoring (LLS) system for all climbers. Results: The overall prevalence of AMS was 31.6% for all participants (LLS score ‡3 with headache, excluding sleep difficulties). A univariate analysis revealed that overnight stay at Mt. Fuji was associated with an increased prevalence of AMS, but that sex and age were not. For overnight lodgers, the mean sleeping altitude in participants with AMS was slightly higher than that in participants without AMS ( p < 0.05). Moreover, participants who stayed above 2870 m were more likely to experience AMS than those who stayed below 2815 m ( p < 0.001), but sex and age were not significantly associated with the probability of experiencing AMS. Conclusions: Staying overnight at a mountain lodge, especially one above 2870 m, may be associated with an increased prevalence of AMS on Mt. Fuji.

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Section: Effect Of Sleeping Altitudesupporting

confidence: 90%

Impact of Sleeping Altitude on Symptoms of Acute Mountain Sickness on Mt. Fuji

Horiuchi

Uno

Endo

et al. 2018

High Altitude Medicine & Biology

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“…The role of periodic breathing in high-altitude sleep disturbance is still being defined. A recent study related improvements in sleep quality to acclimatization and oxygen saturation, and not to changes in periodic breathing (Nussbaumer-Ochsner et al, 2012b).…”

Section: Discussionmentioning

confidence: 99%

A Randomized Trial of Temazepam versus Acetazolamide in High Altitude Sleep Disturbance

Tanner

Thapa

et al. 2013

High Altitude Medicine & Biology

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. A randomized trial of temazepam versus acetazolamide in high-altitude sleep disturbance. High Alt Med Biol 14: [234][235][236][237][238][239] 2013.-This study is the first comparative trial of sleep medications at high altitude. We performed a randomized, double-blind trial of temazepam and acetazolamide at an altitude of 3540 meters. 34 healthy trekkers with self-reports of highaltitude sleep disturbance were randomized to temazepam 7.5 mg or acetazolamide 125 mg taken at bedtime for one night. The primary outcome was sleep quality on a 100 mm visual analog scale. Additional measurements were obtained with actigraphy; pulse oximetry; and questionnaire evaluation of sleep, daytime drowsiness, daytime sleepiness, and acute mountain sickness. Sixteen subjects were randomized to temazepam and 18 to acetazolamide. Sleep quality on the 100 mm visual analog scale was higher for temazepam (59.6, SD 20.1) than acetazolamide (46.2, SD 20.2; p = 0.048). Temazepam also demonstrated higher subjective sleep quality on the Groningen Sleep Quality Scale (3.5 vs. 6.8, p = 0.009) and sleep depth visual analog scale (60.3 vs. 41.4, p = 0.028). The acetazolamide group reported significantly more awakenings to urinate (1.8 vs. 0.5, p = 0.007). No difference was found with regards to mean nocturnal oxygen saturation (84.1 vs. 84.4, p = 0.57), proportion of the night spent in periodic breathing, relative desaturations, sleep onset latency, awakenings, wake after sleep onset, sleep efficiency, Stanford Sleepiness Scale scores, daytime drowsiness, or change in self-reported Lake Louise Acute Mountain Sickness scores. We conclude that, at current recommended dosing, treatment of high-altitude sleep disturbance with temazepam is associated with increased subjective sleep quality compared to acetazolamide.

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“…Apneas may appear as low as 2400 m, increase with increasing altitude (Waggener et al, 1984;Bloch et al, 2010;Nussbaumer-Ochsner et al, 2012) and decrease with acclimatization (Waggener et al, 1984;Goldenberg et al, 1992;Nussbaumer-Ochsner et al, 2012). In high altitude natives such as Aymaras and Sherpas, very few respiratory disturbances during sleep were found (Lahiri et al, 1983;Lahiri and Data, 1992), suggesting an adjustment of nocturnal respiratory pattern in people living permanently at high altitude.…”

Section: Nocturnal Ventilatory Pattern At High Altitudementioning

confidence: 92%

“…Sleep apneas occur during sleep in humans (Lahiri et al, 1983;Berssenbrugge et al, 1983;Wickramasinghe and Anholm, 1999;Küpper et al, 2008;Nussbaumer-Ochsner et al, 2012) and animals (Pappenheimer, 1977;Han et al, 2002;Wilkinson et al, 2005) exposed to hypoxia or high altitude. Apneas may appear as low as 2400 m, increase with increasing altitude (Waggener et al, 1984;Bloch et al, 2010;Nussbaumer-Ochsner et al, 2012) and decrease with acclimatization (Waggener et al, 1984;Goldenberg et al, 1992;Nussbaumer-Ochsner et al, 2012).…”

Section: Nocturnal Ventilatory Pattern At High Altitudementioning

confidence: 99%