Effect of sevoflurane on the ex vivo secretion of TNF-α during and after coronary artery bypass surgery

Azab, S. R. El; Rosseel, Peter; Lange, J. de; Groeneveld, A. B. J.; Strik, R. Van; Wijk, E. M. van; Scheffer, Gert-Jan

doi:10.1017/s0265021503000577

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…It has a low blood/gas partition coefficient and the advantages of anesthesia induction, quick recovery and hemodynamic stability. Sevoflurane has anti-inflammatory properties, and pretreatment with sevoflurane can protect lung tissue from ischemia–reperfusion injury, 2 , 3 but the mechanism of its protective effect on reperfusion injury is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Effects of sevoflurane on tight junction protein expression and PKC-α translocation after pulmonary ischemia–reperfusion injury

et al. 2015

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Pulmonary dysfunction caused by ischemia-reperfusion injury is the leading cause of mortality in lung transplantation. We aimed to investigate the effects of sevoflurane pretreatment on lung permeability, tight junction protein occludin and zona occludens 1 (ZO-1) expression, and translocation of protein kinase C (PKC)-α after ischemia–reperfusion. A lung ischemia-reperfusion injury model was established in 96 male Wistar rats following the modified Eppinger method. The rats were divided into four groups with 24 rats in each group: a control (group C), an ischemia-reperfusion group (IR group), a sevoflurane control group (sev-C group), and a sevoflurane ischemia-reperfusion group (sev–IR group). There were three time points in each group: ischemic occlusion for 45 min, reperfusion for 60 min and reperfusion for 120 min; and there were six rats per time point. For the 120-min reperfusion group, six extra rats underwent bronchoalveolar lavage. Mean arterial pressure (MAP) and pulse oxygen saturation (SpO2) were recorded at each time point. The wet/dry weight ratio and lung permeability index (LPI) were measured. Quantitative RT-PCR and Western blot were used to measure pulmonary occludin and ZO-1, and Western blot was used to measure cytosolic and membranous PKC-α in the lung. Lung permeability was significantly increased after ischemia–reperfusion. Sevoflurane pretreatment promoted pulmonary expression of occludin and ZO-1 after reperfusion and inhibited the translocation of PKC-α. In conclusion, sevoflurane pretreatment alleviated lung permeability by upregulating occludin and ZO-1 after ischemia–reperfusion. Sevoflurane pretreatment inhibited the translocation and activation of PKC-α, which also contributed to the lung-protective effect of sevoflurane.

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Section: Introductionmentioning

confidence: 99%

Effects of sevoflurane on tight junction protein expression and PKC-α translocation after pulmonary ischemia–reperfusion injury

et al. 2015

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“…There are several significant advantages of continuous measurements of systemic inflammation during CPB as compared with conventional techniques that will be useful to the physicians. First, pharmacological agent selection including anesthetic drugs, in conjunction with different modes of perfusion has significant effects on systemic inflammation , and continuous monitoring of inflammatory biomarkers will benefit several ongoing surgical studies of the immune response to the use of certain anesthetic agents and anti‐inflammatory steroids. Online measurements would permit a study of the effects of different pharmacological agents and provide indications for intraoperative substitution of agents.…”

Section: Resultsmentioning

confidence: 99%

Continuous Monitoring of Inflammation Biomarkers During Simulated Cardiopulmonary Bypass Using a Microfluidic Immunoassay Device—A Pilot Study

et al. 2013

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This work demonstrates the use of a continuous online monitoring system for tracking systemic inflammation biomarkers during cardiopulmonary bypass (CPB) procedures. The ability to monitor inflammation biomarkers during CPB will allow surgical teams to actively treat inflammation and reduce harmful effects on postoperative morbidity and mortality, enabling improved patient outcomes. A microfluidic device has been designed which allows automation of the individual processing steps of a microbead immunoassay to allow continuous tracking of antigen concentrations. Preliminary experiments have demonstrated that the results produced by the micro-immunoassay are comparable to results produced from a standard ELISA (r=0.98). Additionally, integration of the assay with a simulated CPB circuit has been demonstrated with temporal tracking of C3a concentrations within blood continuously sampled from the circuit. The presented work describes the motivation, design challenges, and preliminary experimental results of this project.

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“…The cardioprotective effects of a volatile anesthetic regimen during CABG were confirmed in other reports that used different anesthetic and surgical protocols, and in patients undergoing off-pump CABG. 46 –53 These clinical studies clearly indicate that volatile anesthetics protect the myocardium during CABG. However, another study in patients undergoing off-pump CABG observed no significant difference in the incidence of myocardial ischemia.…”

Section: Does Choice Of Anesthetic Regimen Matter In Clinical Practice?mentioning

confidence: 85%

Cardioprotection with Volatile Anesthetics in Cardiac Surgery

Cromheecke

Lorsomradee

Hert

2008

Asian Cardiovasc Thorac Ann

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Myocardial ischemia during the perioperative period is a major cause of morbidity and mortality after surgery. Experimental data indicate that clinical concentrations of volatile anesthetics protect the myocardium from ischemia and reperfusion injury, as shown by decreased infarct size and more rapid postoperative recovery of contractile function. These anesthetics may also mediate protective effects in other organs, such as the brain and kidney. A number of recent reports have indicated that these experimentally observed protective effects might also be present in the clinical setting. Implementation of such cardioprotection during surgery may provide an additional tool in the treatment and prevention of ischemic cardiac dysfunction in the perioperative period. This review discusses the clinical studies that have focused on the potential cardioprotective effects of volatile anesthetic agents.

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Effect of sevoflurane on the ex vivo secretion of TNF-α during and after coronary artery bypass surgery

Abstract: Sevoflurane reduces production of TNF-alpha more than total intravenous anaesthesia with midazolam-sufentanil during cardiac surgery. This may reduce cardiac morbidity and the length of stay in the intensive care unit.

Cited by 14 publications

References 25 publications

Effects of sevoflurane on tight junction protein expression and PKC-α translocation after pulmonary ischemia–reperfusion injury

Effects of sevoflurane on tight junction protein expression and PKC-α translocation after pulmonary ischemia–reperfusion injury

Continuous Monitoring of Inflammation Biomarkers During Simulated Cardiopulmonary Bypass Using a Microfluidic Immunoassay Device—A Pilot Study

Cardioprotection with Volatile Anesthetics in Cardiac Surgery

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