Effect of Severe Obstructive Sleep Apnea on Morphology of Left-Sided Heart and Pulmonary Artery Pressure

Abstract

P = 0.003), higher left ventricular end-systolic volume (53.25 ± 16.69 vs. 38.82 ± 9.36 ml in controls; P = 0.01), higher mean pulmonary artery pressure (19.41 ± 7.89 vs 14.91 ± 3.55 mmHg in controls; P = 0.04), thicker left ventricular posterior wall (1.25 ± 0.13 vs 0.65 ± 0.25 cm in controls; P < 0.001) after controlling for confounders like age, gender, body mass index and systemic hypertension. An index was calculated for the left atrial size and left ventricular volumes with body surface area. Among these indices, only left ventricular end systolic volume index was found to be higher among subjects with severe OSA after controlling for confounders like age, gender, body mass index and systemic hypertension. Conclusion Severe OSA is associated with remodeling of pulmonary vasculature and left-sided chambers of the heart.