Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems

Abstract

The effects of coating thickness, type of adhesive, and type and concentration of enhancer on the mechanical properties of two acrylic pressure-sensitive adhesives (PSAs) were investigated using a 2(4) factorial design and an optimization technique. Sixteen formulations containing 0% or 10% of either caprylic acid or methyl laurate in two different PSAs, namely Duro-Tak 87-2196 and Duro-Tak 87-2097, were prepared. The adhesive properties of these laminates were evaluated by applying the 90 degrees Dynamic Adhesive Strength Peel Test (90 degrees DASPT) and 1800 Release Liner Peel Test (180 degrees RLPT). Coating thickness, concentration of enhancer, and type of adhesive did affect the 90 degrees DASPT. For the 180 degrees RLPT, the most significant factors were coating thickness and concentration of enhancer, with a strong interaction observed between the two. Coating thickness and concentration of enhancer were also used to create mathematical models that correlated these factors with the mechanical properties of the PSAs. For this purpose, the optimization technique 3(2) was applied. It was found that the correlation of the above factors can be adequately described with polynomial equations, which can be used for predicting the mechanical properties of the laminates containing the above PSAs and methyl laurate (0%-10%).

Adhesion and Cellular Compatibility of Silicone‐Based Skin Adhesives

“…Several studies focused on the investigation of mechanical and adhesive behavior of PSAs from natural or synthetic origin, including research on delamination phenomena . The adhesive properties of PSAs can be varied by, e.g., the incorporation of different monomers during the polymerization process . The modification of the viscoelastic properties of different materials directly influences their pull‐off (tack) and peel strength to yield optimum properties for a wide field of applications including surface protection or medicine .…”

Development of Drug-in-Adhesive Patch with a Honeycomb Film as a Backing Layer

“…22) The thickness, composition, shape, and rigidity, which affect flexibility and elongation of the DIA patch, are determination parameters for the peeling force of the applied patch. 23) In the present study, adhesive properties, as well as drug release and skin permeation profiles from the patch, were investigated with the DIA patch with a honeycomb film as a backing layer by comparing the DIA patch with a non-honeycomb PET film and a commercially available product.…”

“…In contrast, the PSA layer in HC-and HO-PSAs only tightly adhered at the lattice structure in the honeycomb film. Since increasing peeling angle 23) and decreasing peeling speed 24) may provide decreasing peeling force of the adhesive patch, the elongation of the PSA layer in the HC-and HO-PSAs may have changed the peeling angle and speed compared with D-PSA. Therefore, the elongation of the layer may be a reason for the decreased number of SC removed by patch peeling.…”

Evaluation and Characterization of Transdermal Therapeutic Systems: An Exhaustive Pictorial and Figurative Review

“…Nitrogen gas was purged at the rate of 10 ml/m for maintaining inert atmosphere 4 . All the prepared patches were visually inspected for color, clarity, flexibility and smoothness 7,8 .…”