Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems

Dimas, Dimitrios A.; Dallas, Paraskevas; Rekkas, Dimitrios M.; Choulis, N.H.

doi:10.1007/bf02830531

Cited by 8 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is reported that the thickness of the adhesive layer has an impact on the peeling force required to remove a patch. A thicker adhesive layer leads to a higher peeling force [1,43,44].…”

Section: Discussionmentioning

confidence: 99%

Evaluating adhesion properties of transdermal adhesives using novel skin mimetic substrate

Bagde,

Mosley-Kellum,

Salau

et al. 2024

Preprint

View full text Add to dashboard Cite

Even though, the transdermal patches are evaluated for adhesion testing using current adhesion protocols (based on stainless steel (SS) probe), they fail to correlate to in vivo studies. Therefore, our objective was to print the probes (skin mimetic substrate) using 3D Fused Deposition Modeling (FDM) printing using materials with similar surface energy as skin and evaluate the adhesion property of pressure sensitive adhesives (PSAs). Additionally, the objective of the present study was to study the effect of various intrinsic factors including coat weight, elastic properties of backing membranes and viscosity of PSAs on adhesion properties of PSAs. Our novel 3D printed polypropylene (PP) probe was successfully printed and postprocessed using FDM printing coupled with automated robotic arm setup for adhesion testing. Probe tack test results showed no significant difference in peak adhesive force in case of skin adhered to SS probe and PP probe. However, PP probe showed about 10.26-fold decrease (p<0.0001) in the adhesive force as compared to SS probe. Effect of coat weight using PP robe results revealed that both amine (PSA-4302) and non-amine (PSA-4501) compatible silicone PSAs showed significant (p<0.05) increase in their adhesion prosperities at 10 mg/cm2 as compared to 5 mg/cm2 coating. Further, choice of backing membrane and viscosity of silicone PSAs also showed significant (p<0.0001) effect on PSAs adhesion property. In conclusion, PP probe could be a promising approach for in vitro adhesion testing of TDS products. Further, intrinsic properties including coat weight and viscosity of silicone PSAs significantly affected their adhesion properties.

show abstract

“…It is reported that the thickness of the adhesive layer has an impact on the peeling force required to remove a patch. A thicker adhesive layer leads to a higher peeling force [1,43,44].…”

Section: Discussionmentioning

confidence: 99%

Evaluating adhesion properties of transdermal adhesives using novel skin mimetic substrate

Bagde,

Mosley-Kellum,

Salau

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…It is reported that the thickness of the adhesive layer has an impact on the peeling force required to remove a patch. A thicker adhesive layer leads to a higher peeling force 1,44,45 . Our peel adhesion data showed a signi cant increase in peel adhesive force at 10 mg/cm 2 as compared to 5 mg/cm 2 coating when the laminates were evaluated using both PP and SS plates.…”

Section: Discussionmentioning

confidence: 99%

Development of Novel Skin Mimetic Substrate to Assess the Adhesion Properties of Transdermal Patches

Bagde,

Mosley-Kellum,

Salau

et al. 2024

Preprint

View full text Add to dashboard Cite

The objective of the present study was to develop novel skin mimetic substrates using 3D Fused Deposition Modeling (FDM) printing using materials with similar surface energy as skin and evaluate the adhesion property of pressure-sensitive adhesives (PSAs). Additionally, the objective was to study the effect of various intrinsic factors, including coat weight, elastic properties of backing membranes, and viscosity of PSAs on adhesion properties of PSAs. Our novel 3D-printed polypropylene (PP) probe was successfully printed and postprocessed using FDM printing coupled with an automated robotic arm setup for adhesion testing. Probe tack test results showed no significant difference in peak adhesive force in case of skin and PP probes. However, PP probes showed about a 10.26-fold decrease (p < 0.0001) in the adhesive force compared to the SS probe. Probe tack and peel adhesion tests of the marketed Salonpas patch also showed a significant decrease (p < 0.0001) in the adhesive force in case of PP as compared to the SS probe/plate. Effect of coat weight using PP probe results revealed that both amine (PSA-4302) and non-amine (PSA-4501) compatible silicone PSAs showed significant (p < 0.05) increase in their adhesion prosperities at 10 mg/cm2 as compared to 5 mg/cm2 coating. Further, the choice of backing membrane and viscosity of silicone PSAs also showed a significant (p < 0.0001) effect on the PSA’s adhesion property. In conclusion, PP probes/plates could be a promising approach for in vitro adhesion testing of TDS products. Further, intrinsic properties, including coat weight and viscosity of silicone PSAs, significantly affected their adhesion properties.

show abstract

“…Tack properties: It is the ability of the polymer to adhere to substrate with little contact pressure. Tack is dependent on molecular weight and composition of polymer as well as on the use of tackifying resins in polymer [55][56][57][58] .…”

Section: Water Vapor Transmission Studies (Wvt)mentioning

confidence: 99%

Transdermal Drug Delivery Systems: An Overview

Ahmed¹,

Karki²,

Charde³

et al. 2011

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

SummaryWith the advent of modern era of pharmaceutical dosage forms, transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems. Transdermal patches are polymeric formulations which when applied to skin deliver the drug at a predetermined rate across dermis to achieve systemic effects. Transdermal dosage forms, though a costly alternative to conventional formulations, are becoming popular because of their unique advantages. Controlled absorption, more uniform plasma levels, improved bioavailability, reduced side effects, painless and simple application and flexibility of terminating drug administration by simply removing the patch from the skin are some of the potential advantages of transdermal drug delivery. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches viz., matrix patches, reservoir type, membrane matrix hybrid patches, drug-in-adhesive patches and micro reservoir patches. In addition, the various methods of evaluation of transdermal dosage form have also been reviewed.

show abstract

Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems

Cited by 8 publications

References 2 publications

Evaluating adhesion properties of transdermal adhesives using novel skin mimetic substrate

Evaluating adhesion properties of transdermal adhesives using novel skin mimetic substrate

Development of Novel Skin Mimetic Substrate to Assess the Adhesion Properties of Transdermal Patches

Transdermal Drug Delivery Systems: An Overview

Contact Info

Product

Resources

About