Effect of serotonin and tricyclic antidepressants on intracellular calcium concentrations in Spisula oocytes

Juneja, Renu; Ito, Etsuro; Koide, S. S.

doi:10.1016/0143-4160(94)90099-x

Cited by 20 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In some animals, neurotransmitters function as triggers for maturation. Thus, in bivalve mollusks, 5-I-rI~ acting via receptors located on oocyte surfaces, initiates maturation divisions, and a number of 5 -H T antagonists specifically block meiosis [36,43,44,48,56,57]. In starfish and vertebrates, neurotransmitters function as modulators of maturation hormones: 1-methyladenine or hypophyseal hormones and progesterone respectively [3,4,9,16,17,24,31,76].…”

Section: Neuronal and Pre-nervous Neurotransmitters As Triggers And Rmentioning

confidence: 99%

Changes in the physiological roles of neurotransmitters during individual development

Buznikov

Shmukler

Lauder

1999

Neurosci Behav Physiol

View full text Add to dashboard Cite

The classical neurotransmitters (acetylcholine and biogenic monoamines) are multifunctional substances involved in intra- and intercellular signaling at all stages of ontogenesis in multicellular animals. A cyclical scheme is proposed to describe age-related changes in neurotransmitter functions at different stages of development from oocyte maturation to neuron formation. This may reflect not only the temporospatial organization of neurotransmitter processes, but also the origin of the functions of acetylcholine and biogenic monoamines from the protosynapses of the cleaved embryo to neuronal synapses.

show abstract

Section: Neuronal and Pre-nervous Neurotransmitters As Triggers And Rmentioning

confidence: 99%

Changes in the physiological roles of neurotransmitters during individual development

Buznikov

Shmukler

Lauder

1999

Neurosci Behav Physiol

View full text Add to dashboard Cite

show abstract

“…We studied the effects of 5-HT, verapamil, and tricyclic antidepressants on [ca2+]i in individual Fura-2 loaded Spisula oocytes ( Juneja et al, 1994). After a lag period of 5 min, an increase in [ca2Ti occurred in 5-HT-treated oocytes .…”

Section: Lntracellular Calcium Concentration [~A2']mentioning

confidence: 99%

“…Stimulation of caz+-influx would lead to the release of intracellular bound calcium which subsequently activates caz+-dependent enzymes and metabolic pathways (Juneja et a1.,1993a;Juneja et al, 1994;Dedman and Kaetzel, 1995). These actions of 5-HT to trigger GVBD, to stimulate ~a~+ -u~t a k e , and to increase [ca2+li are blocked by verapamil, a voltage-sensitive calcium-channel blocker, and by tricyclic antidepressants Juneja et a1.,1993a;Juneja et al, 1994). The role of&+, cyclic nucleotides, protein phosphorylation, and protein kinase C in 5-HTinduced spawning, and oocyte maturation of Spisula is discussed.…”

Section: Introductionmentioning

confidence: 99%

Biochemical pathways involved in serotonin-regulatedSpisulaoocyte maturation and fertilization

Juneja

Koide

1996

Invertebrate Reproduction & Development

View full text Add to dashboard Cite

Full-grown oocytes of the surf clam Spisula solidissima are naturally arrested at the dictyate stage of meiosis and resume maturation following insemination or treatment with various chemical stimuli. Serotonin or 5-hydroxytryptamine (5-HT) triggers spawning when injected into the gonads of Spisula and induces maturation when added in vitro to a suspension of isolated oocytes. The physiological relevance of this observation is supported by the identification of 5-HT or a related compound in the body fluid and ganglion cells of Spisula. 5-HT-induced germinal vesicle breakdown (GVBD) is absolutely dependent on the presence of extracellular calcium in the suspension medium. 5-HT affects ca2+-uptake mediated by voltage-gated ca2+-channels in Spisula oocytes that leads to increased levels of intracellular calcium. Verapamil, a voltage-sensitive ca2+-channel blocker, completely inhibits the actions of 5-HT to induce GVBD, to stimulate ca2+-uptake, and to influence intracellular calcium concentrations [ca2+li. Tricyclic antidepressants block neurotransmitter-induced oocyte maturation by acting as serotonin-receptor antagonists and thus inhibiting 5-HT-affected ca2+-uptake b voltage-gated I+ ca2+-channels. The present results suggest that 5-HT is hctionally affecting Ca -uptake mediated by the gating of verapamil-sensitive ca2+-channels in Spisula oocytes, thereby activating the signal transduction system leading eventually to the resumption of meiosis.

show abstract

“…Klinische Studien wurden mit Flunarizin und Nimodipin, die beide gut die Blut-Hirn-Schranke passieren, durchgeführt. Eckmann (1985a) Aghajanian 1978, Wang u. Aghajanian 1980, Juneja et al 1994. Für Fluoxetin und die MAG-Inhibitoren Iproniazid und Phenelzin sowie für Imipramin wurde eine Abschwächung des serotonininduzierten Einwärtsstromes in isolierten Ganglienzellen der Ratte gefunden (Fan 1994).…”

Section: Kalziumantagonisten Bei Dementen Syndromen Und Depressionunclassified

“…Längerfristig wird auch via Änderung der Zahl, Dichte und Empfindlichkeit von Serotoninrezeptoren eine kalziumantagonistische Wirkung berichtet (de Montigny u. Aghajanian 1978, Wang u. Aghajanian 1980,Juneja et al 1994. Über diesen Mechanismus können auch diejenigen Antidepressiva, z.…”

Section: Diskussionunclassified

Bedeutung kalziumantagonistischer Effekte für die medikamentöse Therapie affektiver Störungen^*

Langosch

Walden²

1998

Fortschr Neurol Psychiatr

View full text Add to dashboard Cite

Disturbances of intra- and extracellular calcium levels are often reported during the course of affective disorders. In this review calcium antagonistic properties of drugs used in the treatment of affective disorders are discussed. The effects of calcium channel blockers in animal models of depression and in clinical trials are compared to established treatment strategies. Knowledge on changes in calcium homoeostasis during the treatment of affective disorders may increase the scope of therapeutic options.

show abstract

Effect of serotonin and tricyclic antidepressants on intracellular calcium concentrations in Spisula oocytes

Cited by 20 publications

References 12 publications

Changes in the physiological roles of neurotransmitters during individual development

Changes in the physiological roles of neurotransmitters during individual development

Biochemical pathways involved in serotonin-regulatedSpisulaoocyte maturation and fertilization

Bedeutung kalziumantagonistischer Effekte für die medikamentöse Therapie affektiver Störungen^*

Contact Info

Product

Resources

About

Effect of serotonin and tricyclic antidepressants on intracellular calcium concentrations in Spisula oocytes

Cited by 20 publications

References 12 publications

Changes in the physiological roles of neurotransmitters during individual development

Changes in the physiological roles of neurotransmitters during individual development

Biochemical pathways involved in serotonin-regulatedSpisulaoocyte maturation and fertilization

Bedeutung kalziumantagonistischer Effekte für die medikamentöse Therapie affektiver Störungen*

Contact Info

Product

Resources

About

Bedeutung kalziumantagonistischer Effekte für die medikamentöse Therapie affektiver Störungen^*