Changes in the physiological roles of neurotransmitters during individual development

Buznikov, G. A.; Shmukler, Yuri B.; Lauder, Jean M.

doi:10.1007/bf02461353

Cited by 31 publications

(20 citation statements)

References 79 publications

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“…165,167 To date, it has been reported that oocytes of starfish, fish, amphibians, and mammals contain 5-HT, and 5-HT receptors have been detected on the cell surface of oocytes as well as follicular cells of various species. 168 Even prior to the presence of differentiated serotonergic neurons releasing neurotransmitter, 5-HT is involved in the regulation of basic developmental processes related to early embryogenesis, including cell proliferation, migration, differentiation, and morphogenetic cell movements during gastrulation and postgastrulation. 165 By controlling morphogenesis, for instance, 5-HT of maternal origin appears to influence the development and maturation of the mouse brain.…”

Section: Serotonergic Regulation Of Embryo Developmentmentioning

confidence: 99%

Physiological Endpoints for Potential SSRI Interactions in Fish

Kreke

Dietrich

2008

Critical Reviews in Toxicology

114

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Selective serotonin reuptake inhibitors (SSRIs) are among the pharmaceutical compounds frequently detected in sewage treatment plant effluents and surface waters, albeit at very low concentrations, and have therefore become a focus of interest as environmental pollutants. These neuroactive drugs are primarily used in the treatment of depression but have also found broader use as medication for other neurological dysfunctions, consequently resulting in a steady increase of prescriptions worldwide. SSRIs, via inhibition of the serotonin (5-hydroxytryptamine, 5-HT) reuptake mechanism, induce an increase in extracellular 5-HT concentration within the central nervous system of mammals. The phylogenetically ancient and highly conserved neurotransmitter and neurohormone 5-HT has been found in invertebrates and vertebrates, although its specific physiological role and mode of action is unknown for many species. Consequently, it is difficult to assess the impact of chronic SSRI exposure in the environment, especially in the aquatic ecosystem. In view of this, the current knowledge of the functions of 5-HT in fish physiology is reviewed and, via comparison to the physiological role and function of 5-HT in mammals, a characterization of the potential impact of chronic SSRI exposure on fish is provided. Moreover, the insight on the physiological function of 5-HT strongly suggests that the experimental approaches currently used are inadequate if not entirely improper for routine environmental risk assessment of pharmaceuticals (e.g., SSRIs), as relevant endpoints are not assessed or impossible to determine.

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Section: Serotonergic Regulation Of Embryo Developmentmentioning

confidence: 99%

Physiological Endpoints for Potential SSRI Interactions in Fish

Kreke

Dietrich

2008

Critical Reviews in Toxicology

114

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“…In particular, studies of the functional linkage of such systems with various second messengers were very relevant [3,5,10,22,34]. One of these studies [4] showed that acetylcholine increases the level of specific anomalies arising as a result of exposure of early sea urchin embryos to protein kinase C activators.…”

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confidence: 99%

Cholinoreceptors of early (preneural) sea urchin embryos

Buznikov

Rakich

2000

Neurosci Behav Physiol

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Agonists of nicotinic cholinoreceptors (n-AChR) and 1-acetyl-4-methylpiperazine (100 microM) had no effect on early embryogenesis in sea urchins, while in the presence of phorbol-12-myristate-13-acetate (PMA) and various other protein kinase C activators, these agents induced rapid lysis of oocytes or early embryos, as a result of calcium shock. Many n-AChR ligands which do not penetrate into the cytoplasm (not being antagonists of muscarinic cholinoreceptors) protected against this cytotoxic effect. In the presence of PMA, acetylcholine and carbachol had actions which were much weaker than those of nicotine, while muscarine was completely inactive in these conditions. Thus, the surfaces of sea urchin oocytes and early embryos bear receptor structures, presumably n-AChR, which are functionally linked with second messengers which are endogenous protein kinase C activators.

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“…We hypothesize that neurotransmitters could mediate the homotypic inhibitory signaling implied by our results. Several attributes of neurotransmitters and their signaling mechanisms make them attractive candidates: they provide a basis for cell-type specificity; plausible mechanisms for neurotransmitter delivery have been reported, including volume transmission of molecules released from a synaptic apparatus (Mora-Ferrer et al, 1999;Cragg and Rice, 2004); neurotransmitters can activate complex intracellular signaling cascades, potentially resulting in changes in gene transcription (Paspalas and Goldman-Rakic, 2004); neurotransmitters are known to regulate various aspects of cellular development (Lankford et al, 1988;Rodrigues et al, 1990;Jung and Bennett, 1996;Lima et al, 1996;Buznikov et al, 1999;Moiseiwitsch, 2000;Zachor et al, 2000;Herlenius and Lagercrantz, 2001). Direct evaluation of the neurotransmitter hypothesis of cell-fate determination and cellular pattern formation in the growing goldfish retina is the subject of ongoing investigation.…”

Section: Hypothesized Signaling Mechanisms For Controlling Cell-fate mentioning

confidence: 99%

Control of Cellular Pattern Formation in the Vertebrate Inner Retina by Homotypic Regulation of Cell-Fate Decisions

Tyler¹,

Carney²,

Cameron³

2005

J. Neurosci.

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The vertebrate retina is composed of cellular arrays that are nonrandom across two-dimensional space. The determinants of these nonrandom two-dimensional cellular patterns in the inner nuclear layer of the retina were investigated using empirical and computational modeling techniques. In normal and experimental models of goldfish retinal growth, the patterns of tyrosine hydroxylase-and serotonin-positive cells indicated that neither cell death nor lateral migration of differentiated cells were dominant mechanisms of cellular pattern formation. A computational model of cellular pattern formation that used a signaling mechanism arising from differentiated cells that inhibited homotypic cell-fate decisions generated accurate simulations of the empirically observed patterns in normal retina. This model also predicted the principal atypical cellular pattern characteristic, a transient cell-type-specific hyperplasia, which was empirically observed in the growing retina subsequent to selective ablation of differentiated retinal cells, either tyrosine hydroxylase positive or serotonin positive. The results support the hypothesis that inhibitory spatiotemporal regulation of homotypic cell-fate decisions is a dominant mechanistic determinant of nonrandom cellular patterns in the vertebrate retina.

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Changes in the physiological roles of neurotransmitters during individual development

Cited by 31 publications

References 79 publications

Physiological Endpoints for Potential SSRI Interactions in Fish

Physiological Endpoints for Potential SSRI Interactions in Fish

Cholinoreceptors of early (preneural) sea urchin embryos

Control of Cellular Pattern Formation in the Vertebrate Inner Retina by Homotypic Regulation of Cell-Fate Decisions

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