“…Sericin has multifunctional properties, including not only antioxidant effects (Isobe et al, 2012;Takechi, Wada, Fukuda, Harada, & Takamura, 2014) but also stimulation of cell proliferation (Terada, Nishimura, Sasaki, Yamada, & Miki, 2002), improvement of cryotolerance (Miyamoto et al, 2010(Miyamoto et al, , 2012Ohnishi et al, 2012), and progression of oocyte maturation (Do et al, 2014), in addition to its use as a substitute for FBS on cell culture (Hosoe et al, 2014;Terada, Sasaki, Yanagihara, & Yamada, 2005). Therefore, although detailed mechanism is not clear, these properties of sericin may synergistically affect to protect embryos from heat shock.…”