Effect of Semisolid Formulation of Persea Americana Mill (Avocado) Oil on Wound Healing in Rats

Abstract

The aim of this study was to evaluate the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natura, on incisional and excisional cutaneous wound models in Wistar rats. An additional objective was to quantify the fatty acids present in avocado oil. On the 14th day, a significant increase was observed in percentage wound contraction and reepithelialization in the groups treated with 50% SSFAO or avocado oil compared to the petroleum jelly control. Anti-inflammatory activity, increase in density of collagen, and tensile strength were observed inSSFAO 50% or avocado oil groups, when compared to control groups. The analysis of the components of avocado oil by gas chromatography detected the majority presence of oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%). Our results show that avocado oil is a rich source of oleic acid and contains essential fatty acids. When used in natura or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process and may thus be considered a new option for treating skin wounds.

The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats

“…The percentage of wound contraction at each time point was derived by the following formula: wound contraction percentage ¼ (initial wound area − current wound area)/initial wound area  100 %. Epithelialization period was evaluated as the number of days for each scar to vanish and it must be noted that no raw wound left behind as it was monitored [5,11,[26][27][28].…”

Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology

“…Vegetable butters and oils have shown promising results in in vitro and in vivo studies. They affect phases of the wound‐healing process through their bacteriostatic, antimicrobial, anti‐inflammatory, and antioxidative activities and by promoting cell proliferation, increasing collagen synthesis, stimulating dermal reconstruction, and repairing the skin's lipid barrier function (Cornily et al, ; de Oliveira et al, ; Lamaud, Huc, & Wepierre, ; Lewinska, Zebrowski, Duda, Gorka, & Wnuk, ; T.‐K. Lin, Zhong, & Santiago, ; Mandawgade & Patravale, ; Nasopoulou, Karantonis, Detopoulou, Demopoulos, & Zabetakis, ; Shinagawa, de Santana, Torres, & Mancini‐Filho, ; Vaughn, Clark, Sivamani, & Shi, ).…”

“…Lin, Zhong, & Santiago, ; Mandawgade & Patravale, ; Nasopoulou, Karantonis, Detopoulou, Demopoulos, & Zabetakis, ; Shinagawa, de Santana, Torres, & Mancini‐Filho, ; Vaughn, Clark, Sivamani, & Shi, ). Fatty acids were shown to play major role in the wound‐healing process (Cardoso, Souza, Ferro, Favoreto, & Pena, ; de Oliveira et al, ; McDaniel, Belury, Ahijevych, & Blakely, ). Linolenic, linoleic, and oleic acids are precursors for the synthesis of inflammatory or anti‐inflammatory mediators and are part of the structure of cell membrane phospholipids, ceramides, and sebum, that is, important components of the lipid barrier (Hankenson, Watkins, Schoenlein, Allen, & Turek, ; Lewinska et al, ; Ruthig & Meckling‐Gill, ).…”

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

“…Avocado oil is a functional oil extracted from the avocado pulp and has been widely utilised in the dietary supplement and healthcare products. Previously, avocado oil has been reported to possess pharmacologic and therapeutic effects on osteoarthritis treatment (Kucharz, ), blood pressure management (Salazar et al ., ), wound healing (Oliveira et al ., ), body weight management (Furlan et al ., ) and diabetes treatment (Ortiz‐Avila et al ., ) as it contains a variety of bioactive compounds. A latest study performed by Furlan et al .…”

“…Avocado oil is a functional oil extracted from the avocado pulp and has been widely utilised in the dietary supplement and healthcare products. Previously, avocado oil has been reported to possess pharmacologic and therapeutic effects on osteoarthritis treatment (Kucharz, 2003), blood pressure management (Salazar et al, 2005), wound healing (Oliveira et al, 2013), body weight management (Furlan et al, 2017) and diabetes treatment (Ortiz-Avila et al, 2017) as it contains a variety of bioactive compounds. A latest study performed by Furlan et al (2017) suggested the hypocholesterolaemic potential of avocado oil, whereby their study showed that substitution of butter with avocado oil resulted in decreased levels of cholesterol, LDL-C and triglyceride in overweight subjects.…”