Effect of Selenium-Containing Products on Antioxidant Enzyme Activity in the Kidneys, Liver, and Blood of Guinea Pigs

Sirota, T. V.

doi:10.1007/s10517-010-0958-4

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Therefore, there is a clear relationship between Se deficiency, GPx activity, and protein oxidation in liver, which is also parallel to low liver development. This increase in SOD activity in conditions of Se deficiency has also been detected by other authors in mouse liver (Stỳblo et al 2007), as well as in other tissues (Sirota 2010, Erkekoglu et al 2012. This increase in SOD activity could be to compensate the formation of more superoxide generated by mitochondrial dysfunction, caused in part by the increase in reactive oxygen species (ROS; Shi et al 2012), by the decrease in Se levels that are related to a correct mitochondrial function and its biogenesis (Mehta The results are expressed as meanGS.E.M.…”

Section: Antioxidative Defense and Oxidative Stress Markers In Liversupporting

confidence: 86%

Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring

Nogales¹,

Ojeda²,

Fenutría³

et al. 2013

Reproduction

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Selenium (Se), an essential trace metal, is important in both growth and reproduction and is the constituent of different selenoproteins. The glutathione peroxidase (GPx) family is the most studied as it prevents oxidative stress. Liver oxidation is considered as another mechanism involved in low birth weight. Therefore, in order to ascertain whether GPx is related to the effects of Se on growth during gestation and lactation, three groups of rat pups were used: control, Se deficient (SD), and Se supplemented (SS). Morphological parameters and reproductive indices were evaluated. Hepatic Se levels were measured by graphite furnace atomic absorption while spectrophotometry was used for activity of antioxidant enzymes and oxidative stress markers in liver and western blotting for expression of hepatic GPx1 and GPx4. The SD diet increased mortality at birth; decreased viability and survival indices; and stunted growth, length, and liver development in offspring, thus decreasing hepatic Se levels, GPx, glutathione reductase, and catalase activities, while increasing superoxide dismutase activity and protein oxidation. The SS diet counteracted all the above results. GPx1 expression was heavily regulated by Se dietary intake; however, although Se dietary deficiency reduced GPx4 expression, this decrease was not as pronounced. Therefore, it can be concluded that Se dietary intake is intimately related to growth, length, and directly regulating GPx activity primarily via GPx1 and secondly to GPx4, thus affecting liver oxidation and development. These results suggest that if risk of uterine growth retardation is suspected, or if a neonate with low birth weight presents with signs of liver oxidation, it may be beneficial to know about Se status.

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Section: Antioxidative Defense and Oxidative Stress Markers In Liversupporting

confidence: 86%

Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring

Nogales¹,

Ojeda²,

Fenutría³

et al. 2013

Reproduction

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“…Alpha-toc protects the unsaturated fatty acids of membrane phospholipids from oxidative degeneration through the formation of unreactive radical species and breaking the free radical reactions chain [36]. It is a useful free radical scavenger against stress conditions in several tissues [46]. The increases in selenium-dependent antioxidant enzymes activities decrease free radical-mediated lipid peroxidation and regenerate reduced glutathione.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that alpha-toc has the ability to protect against lipid peroxidation through the oxygen scavenging activity, neutralizing the lipid peroxidation and unsaturated membrane lipids [47]. Stimulation of the radical scavenger and the increase in the antioxidant defense mechanism might be the protecting role of selenium against lipid peroxidation [46].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Selenium and Alpha-Tocopherol against Lead-Induced Hepatic and Renal Toxicity in Oreochromis Niloticus

Khalil¹

2014

J Aquac Res Development

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Lead is a serious poison causing serious injury or death. Current study was designed to investigate the potential protective effect of selenium (Se) and alpha-tocopherol (alpha-toc) against the hepatic and renal toxicity of lead acetate in Oreochromis niloticus. Two hundred and twenty five O. niloticus were divided into five groups; control, lead acetate treated (73.40 mg/liter), Se treated (4 mg sodium selenite/ kg diet), alpha-toc treated (200 mg/kg diet) plus Se + alpha-toc co-treated groups for 10 weeks. Levels of aspartate aminotransferase (AST), alanine transaminase (ALT), total protein, urea, creatinine, calcium (Ca), inorganic phosphate (P), magnesium (Mg), superoxide dismutase (SOD), reduced glutathione (GSH) and the lipid peroxidation index (MDA) were determined The results revealed an increase in the levels of liver enzymes, urea, creatinine and MDA; meanwhile, the total protein, Ca, P, Mg, SOD and GSH were decreased. Therefore, it could be concluded that selenium (Se) and alpha-tocopherol (alpha-toc) may be useful tool to minimize the toxic effects of lead toxicity by its potent antioxidant activity.

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Nephroprotective and antioxidant significance of selenium and α-tocopherol on lead acetate-induced toxicity of Nile Tilapia (Oreochromis niloticus)

Hashish

Elgaml

El-Murr

et al. 2015

Fish Physiol Biochem

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The kidney plays an important physiological function, maintaining the osmoregulation and electrolyte balance of Nile tilapia (Oreochromis niloticus). Selenium and α-tocopherol (α-toc) are potent antioxidants, which improve the aquaculture health. In this study, we tested the potential ability of selenium and α-toc to alleviate the oxidative stress in the kidney induced by lead toxicity. Two hundred and twenty-five O. niloticus were divided into five groups. The control group received a basal diet. Lead nephrotoxicity was induced by daily application of 73.40 mg lead acetate/liter water for up to 10 weeks. Selenium and α-tocopherol were given 1 week before lead intoxication. Selenium was administered as sodium selenite, 4 mg/kg dry diet. Alpha-tocopherol acetate was administered as α-toc, 200 mg/kg dry diet. The last group received a mixture of selenium and α-toc in diet. Fish treated with selenium and/or α-toc (groups III-V) showed an amelioration of the adverse effects of lead toxicity and significant improvement in serum electrolytes (calcium, inorganic phosphate, and magnesium) and creatinine level compared with the positive control group (P ≤ 0.05). Treated groups showed significant decrease in superoxide dismutase (SOD) and reduced glutathione (GSH) activity with significant increase in malondialdehyde (MDA; P ≤ 0.05). It could be concluded that selenium and α-toc have a potential antioxidant effect and have the ability to improve the kidney function after lead intoxication of O. niloticus.

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Effect of Selenium-Containing Products on Antioxidant Enzyme Activity in the Kidneys, Liver, and Blood of Guinea Pigs

Cited by 7 publications

References 9 publications

Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring

Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring

Protective Effects of Selenium and Alpha-Tocopherol against Lead-Induced Hepatic and Renal Toxicity in Oreochromis Niloticus

Nephroprotective and antioxidant significance of selenium and α-tocopherol on lead acetate-induced toxicity of Nile Tilapia (Oreochromis niloticus)

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