Protective Effects of Selenium and Alpha-Tocopherol against Lead-Induced Hepatic and Renal Toxicity in Oreochromis Niloticus

Khalil, Shimaa A Elgaml Ryad

doi:10.4172/2155-9546.1000299

Cited by 7 publications

(2 citation statements)

References 44 publications

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“…9 Different studies showed beneficial renoprotection effects of selenium in lead and cadmium toxicities. 37,38 Plasma glutathione peroxidase produced mainly by kidneys. 24 Selenium can increase glutathione peroxidase production and activity.…”

Section: Renoprotectionmentioning

confidence: 99%

Protective Effects of Selenium in Patients with Beta-Thalassemia Major

Jouyban

Chavoshi

et al. 2020

Pharm Sci

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Background: Beta-thalassemia major patients require repeated blood transfusion which is associated with iron overload in different organs such as heart, liver, kidney and their related complications. In this study the effects of selenium in iron overload related complications of patients with beta-thalassemia major were assessed. Methods: In this clinical trial, 34 beta-thalassemia major patients over 12 years old were enrolled. Patients with severe renal failure, history of selenium consumption over the last three months, change of blood transfusion pattern, and any change of chelating agent were excluded from the study. For all patients, tablet of selenium 200 µg/day was administered for a month. Blood samples were taken at baseline and after one-month to assess the level of ferritin, total iron-binding capacity (TIBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine (Scr), selenium. Hair loss was assessed by questionnaire before and after intervention. Results: From 34 patients, 27 (79.4%) had deficient level of selenium at baseline. The selenium level was increased after intervention (p=0.005). The level of serum ALT and Scr decreased remarkably after one-month selenium consumption (p=0.007 for both). In addition, the AST level decreased remarkably after intervention (p=0.053). Severe hair loss profile has improved significantly after supplementation (p=0.004). Conclusion: One-month selenium consumption improved liver and kidney function related markers remarkably. Moreover, selenium improved hair profile and severe hair loss in thalassemia patients. Further studies are needed on the effect of selenium administration on liver and kidney function.

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Section: Renoprotectionmentioning

confidence: 99%

Protective Effects of Selenium in Patients with Beta-Thalassemia Major

Jouyban

Chavoshi

et al. 2020

Pharm Sci

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“…The antioxidants compose the group of drugs which has been investigated the most. Selenium and α-tocopherol showed the positive effect for the level of aspartate and alanine transaminases, total protein, urea, creatinine, superoxide dismutase and glutathione, as well as the lipid peroxidation index [33]. Some drugs like morpholine salt of titanic acid with membrane stabilizing and antioxidant properties and sulfur-containing products inproved hepatocytes morphology and biochemical parameters [1].…”

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confidence: 99%

Pathomorphology of fetal and mature liver under the lead intoxication and after the correction: the review of experimental data

Dovhal

Romanenko³

2019

Patologìâ

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A-research concept and design; B-collection and/or assembly of data; C-data analysis and interpretation; D-writing the article; E-critical revision of the article; F-final approval of the article Lead is one of the most widespread pollutant which alters the mature liver and is especially harmful for the fetal liver. The typical alterations in the mature liver after the lead exposure are the hypertrophy and vacuolization of hepatocytes, circulatory disorders, mononuclear cellular infiltration. The morphological changes in the liver during prenatal development under the maternal lead treatment are inhibition of hematopoiesis, dystrophy of hepatocytes, disturbances in the liver architecture, its vessels and stroma with a gradient of pathological changes toward the peripheral parts of the organ. The manifestations of liver alteration after birth become deeper with age and develop to the necrosis, edema and inflammation. The biochemical disturbances in the liver are the decrease in the activity of enzyms of energy metabolism, inhibition of protein and nucleic acids synthesis, imbalance of the lipid peroxide oxidation system, and the increasing of oxidative stress with the further alteration of the membranes of the endothelium, red blood cells, hepatocytes, as well as mitochondrial membrane.

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