Effect of selected wound antiseptics on adult articular cartilage (bovine sesamoid bone) in the presence of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>

Objective: Daily wound assessment, including dressing changes and the removal of old ointments causes discomfort for the patient. We therefore developed a new thermoreversible and transparent gel formulation that allows for filling wounds of different shapes and depths. The aim of the study was to investigate the effect of a wound covering gel on wound healing and the skin’s microcirculation. Materials and Methods: Investigations were carried out in a standardized and reproducible wound model (hairless mice SKH1/hr, n = 30). Three groups were studied by intravital fluorescence microscopy: treatment with polihexanide-preserved wound covering gel, a formulation containing 3% povidone (PVP)-iodine, and physiological saline for control. Microcirculatory standard parameters were analysed. Results: The non-perfused area vanished within 14 days due to angiogenesis. The venular diameter, oedema formation and functional capillary density showed no significant differences between the three groups. Conclusion: The use of the newly developed wound covering gel has no toxic effects on microcirculation and angiogenesis and reveals no significant differences in the overall assessment of microcirculation compared to the control group and the well-established PVP-iodine. The transparent antibacterial wound covering gel allows for direct wound assessment. Due to its thermoreversible gel formulation it enables good wound contact and easy handling.

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“…In contrast to iodine, no toxic effects of polihexanide on wound healing have as yet been reported in the literature [10,12,16] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Goertz

Ring²,

Knie³

et al. 2009

Eur Surg Res

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“…A comparative in vitro study of cell toxicity reported best results of polyhexanide compared to octenidine and povidone-iodine [10] . Thus far no toxic effects of polyhexanide on wound healing have been reported in the literature [4,6,11,12] , whereas polyhexanide shows a good microbicidal activity and therefore qualifies for reduction in bacterial populations on the wounds [2,13,14] . Accordingly, in our study no infection was seen.…”

Section: Discussionmentioning

confidence: 99%

Clinical Safety and Efficacy of a Novel Thermoreversible Polyhexanide-Preserved Wound Covering Gel

et al. 2010

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Background: An ideal topical formulation for wound therapy does not exist. The aim of this study was to develop a novel improved therapeutic option for the treatment of acute and chronic wounds. Methods: A transparent wound gel which is in a liquid state below and in a gel state at or above room temperature was developed. Forty-four patients were included in this open randomized controlled single-center study. Flammazine™ served as control in the treatment of skin graft donor sites. Wounds were assessed for time of dressing change and overall satisfaction of patients and health care providers. The data were analyzed using the nonparametric Mann-Whitney test. Results: The wound gel proved to be superior in comparison with Flammazine with respect to wound assessment (p = 0.002), staining (p = 0.007), leaking (p = 0.032) and smell (p = 0.034). Flammazine showed favorable results regarding the parameters dehydration of the dressings (p = 0.012) and wound adherence (p = 0.005). The evaluation of the overall dressing change process showed no significant differences. Conclusion: The thermoreversible wound gel containing polyhexanide allows for good handling and wound assessment. This study demonstrated a high satisfaction level of patient and health care providers, and the wound gel proved an effective alternative to commonly used treatments.

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“…PHMB was effective against planktonic E. coli and S. aureus as well as P. aeruginosa in suspension and biofilms [37,38,39,40,41,42,51,52,53]. In addition, PHMB was also effective against E. faecalis and C. albicans [54], as well as against intracellular bacteria such as Chlamydia sp.…”

Section: Resultsmentioning

confidence: 99%

Clinical Use of the Antiseptic Polihexanide for Genital Tract Infections

Koban

Bender

Assadian

et al. 2012

Skin Pharmacol Physiol

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Background: In clinical practice, treatment of genital tract infections is based on administration of either antibiotics or antiseptics. While antibiotics may be applied systemically or topically, antiseptics may be applied only topically. In case of bacterial vaginosis (BV), antibiotic therapy may often be limited and side effects due to systemic administration may develop. Polihexanide (PHMB) is a promising option for the topical treatment of genital tract infections, in particular BV and vaginitis. Method: A systematic search for publications on the use of PHMB for the treatment of genital infections in two electronic databases was performed. Titles, abstracts and citations were imported into a reference database. Duplicates were removed and two reviewers assessed each identified publication separately. Results: Among a total of 204 references, 3 prospective randomized trials were identified. Two trials treated BV infections with PHMB in comparison to clindamycin as antibiotic standard therapy with no significant differences either in safety or in efficacy. The third controlled trial investigated the clinical efficacy of PHMB compared to placebo in the treatment of human papilloma virus. Patients treated with PHMB daily for up to 16-weeks showed significantly higher (52%) clearance of genital warts as compared to patients treated with placebo (4%). Conclusion: PHMB may be a clinically effective alternative for the treatment of BV and human papilloma virus. Although PHMB-based antiseptics are available since the late 90s, controlled trials to investigate its clinical potential for antiseptic treatment are scant. Clinical use of antiseptics for the treatment of infectious diseases should be explored and supported further.

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Effect of selected wound antiseptics on adult articular cartilage (bovine sesamoid bone) in the presence of Escherichia coli and Staphylococcus aureus

Abstract: After removing an inoculum of 108-10' cfu of Esckrrichiu coli (E. cdi)

Cited by 72 publications

References 29 publications

Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Clinical Safety and Efficacy of a Novel Thermoreversible Polyhexanide-Preserved Wound Covering Gel

Clinical Use of the Antiseptic Polihexanide for Genital Tract Infections

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