Effect of segment structures on the hydrolytic degradation behaviors of totally degradable poly(L‐lactic acid)‐based copolymers

Abstract

A series of high‐molecular‐weight terpolymers named PTG‐b‐LG and PT‐b‐LG were synthesized based on the macroinitiators of PTG copolymers and PTMC, respectively. In vitro degradation of PTG‐b‐LG and PT‐b‐LG was carried out by immersing into PBS, in comparison with that of PLLA. Mass loss, water uptake, GPC, DSC, WAXD, and 1H NMR were examined for the degradation study. It was found that PTG‐b‐LG degraded faster than PT‐b‐LG and PLLA due to the Di‐random block structure, which had lower regularity of chain and lower crystallinity. The compositional changes appeared to be more complex, but the molar mass decreased owing to chain fragmentation caused by hydrolysis. Moreover, morphological changes were also observed during the degradation in all situations with the crystallization of by‐products and a preferential degradation of amorphous domains. Specifically, PTG‐b‐LG presented an adjustable degradation rate and may be used for the fabrication of totally biodegradation stents in the future. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47887.

Synergistic effect of adding lignin and carbon black in poly(lactic acid)

“…To be considered a biodegradable polymer, it must present, after significant degradation, final products compatible with the environment, such as carbon dioxide, water and microbial biomass [9] . Among the biodegradable polymers, the poly(lactic acid) (PLA) is one of those that has attracted researchers attention due possesses a variety of desirable properties, such as biodegradability, biocompatibility and exhibiting excellent mechanical properties under tensile tests [10,11] . As limitations, PLA has a high cost, low mechanical toughness, and degradation that ranges from 6 months to 2 years, depending on the conditions under which the material is submitted [12,13] .…”

Surface Modification of PTLG Terpolymer Using PNIPAAm and Its Cell Adhesion/Detachment Behavior

“…The number‐average molecular weight () of PTMC macroinitiator is 3 × 10 4 g mol −1 . PTMC was prepared by ROP where catalyzed by Zn(acac) 2 ·H 2 O and initiated by propylene glycol 1,28. Then, the sample was dissolved in dichloromethane in Quartz box.…”

“…PTMC was prepared by ROP where catalyzed by Zn(acac) 2 ·H 2 O and initiated by propylene glycol. [1,28] Then, the sample was dissolved in dichloromethane in Quartz box. After solvent evaporation, the membranes dried by vacuum chamber at 40 °C for 72 h. Finally, the membranes were cut into square specimens with dimensions of ≈10 × 10 × 0.3 mm.…”

A review on biodegradable biliary stents: materials and future trends

“…One of the major advantages of this 3D4P technology is that it has an extremely high efficiency in producing porous tubular scaffolds because it greatly reduces the number of layers needed to produce a tubular scaffold. 3D4P also has been used to print biodegradable peripheral stents using novel biodegradable copolymers, such as Poly(TMC‐b‐(LLA‐ran‐GA)) [ 66 , 67 ]. It is therefore anticipated that 3D4P will be a promising fabrication technology for developing biliary stents.…”