Effect of secretin and graded doses of CCK-PZ on pancreatic secretion in man

Vaysse, Nicole; Laval, J; Duffaut, M; Ribet, A

doi:10.1007/bf01076211

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…In fact, the mean bicarbonate output is similar to that obtained with infusion of maximal doses of secretin (3,10,12,18) or secretin plus CCK (15,17). As a maximal dose of secretin was not used in this study, this result confirms the enhancing effect of caerulein on secretininduced bicarbonate secretion already reported by others (8,9).…”

Section: Discussionsupporting

confidence: 80%

Investigation of Exocrine Pancreatic Function by Continuous Infusion of Caerulein and Secretin in Normal Subjects and in Chronic Pancreatitis

et al. 1976

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Exocrine pancreatic function has been evaluated in 24 controls and 29 patients with confirmed chronic pancreatitis by continuous infusion (90 min) of synthetic caerulein, 100 ng/kg/h, plus GIH secretin, 1 CU/kg/h. Mean secretory values of the controls were comparable to those obtained by others using maximal doses of secretin and CCK. Unlike the controls, patients suffering from chronic pancreatitis demonstrated a progressive reduction in secretion during infusion. Thus, the comparison of responses for the final 30-min period gave much clearer and more complete discrimination between normal and abnormal pancreatic function than the preceding 30-min period.

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Section: Discussionsupporting

confidence: 80%

Investigation of Exocrine Pancreatic Function by Continuous Infusion of Caerulein and Secretin in Normal Subjects and in Chronic Pancreatitis

et al. 1976

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“…The maximal bicarbonate secretion observed in this study is of the same order of magnitude as has been reported by others using highly purified natural secretin as well as synthetic secretin (Wormsley, 1968;Petersen, 1970;Konturek, 1970;Berstad et al, 1974;Gutierez and Baron, 1973;Farooq etal., 1974;Vaysse et al, 1974). It can, therefore, be assumed that our higher dose of 2-7 CU/kg/h was sufficiently large to give virtually maximal response in the subjects studied.…”

Section: Discussionmentioning

confidence: 92%

“…In its natural physiological setting, however, secretin may be far more effective than in the fasting state. It has convincingly been shown that cholecystokinin at least doubles the effectiveness of secretin at lower dose levels (Vaysse et al, 1974) and cholecystokinin is probably significantly raised during duodenal acidification . Thus a smaller secretin increment than seen after intraduodenal acid may be an equally effective bicarbonate stimulus in the postprandial state.…”

Section: Discussionmentioning

confidence: 99%

Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.

Häcki¹,

Bloom²,

Mitznegg³

et al. 1977

Gut

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“…Also the 'priming' effect of secretin and CCK-octapeptide on acinar cells in their response to the other secretagogue (secre tin to CCK-octapeptide and CCK-octapeptide to secretin) is an important observation. Related to this, findings of potentiation of secretin stimulation of pancreas in vivo by CCK (3,17,19,20,29) or caerulein, and potentia tion of CCK or caerulein stimulation in pan creas in vivo by secretin (10,20,21,26) had been reported. As these results suggest, a differ ent although perhaps analogous mechanism is involved in enzyme secretion by the pancreas as stimulated by secretin and CCK-octapeptide.…”

Section: Discussionmentioning

confidence: 99%

Effect of CCK-Octapeptide and Secretin on Amylase Secretion in Isolated Rat Pancreatic Acinar Cells

Lee¹

1979

Digestion

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Isolated acinar cells from rat pancreas responded well to hormonal treatment. Both secretin (synthetic and highly purified from porcine origin) and CCK-octapeptide stimulated amylase secretion in these cells. The response in both cases was very rapid. A maximal output of enzyme was reached within 5–lOmin after the addition of hormones. The concentration producing maximal output for synthetic secretin (Schwarz/Mann) was 5 X 10^-8M, synthetic secretin (Squibb), 10^-5M, for purified porcine secretin, 10^-5M, and for CCK-octapeptide was 5 X 10^-10M. Secretin (2-fold at optimal concentration) was found to be less efficient compared to CCK-octapeptide (5-fold at optimal concentration) in stimulating amylase release. A combination of secretin and CCK-octapeptide had a synergistic action in stimulating enzyme release by the acinar cells. In addition, pretreatment of acinar cells with secretin potentiated the secretory response of the treated cells to CCK-octapeptide. To a lesser extent pretreatment with CCK-octapeptide also increased the effect of secretin in stimulating enzyme secretion.

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Effect of secretin and graded doses of CCK-PZ on pancreatic secretion in man

Cited by 8 publications

References 10 publications

Investigation of Exocrine Pancreatic Function by Continuous Infusion of Caerulein and Secretin in Normal Subjects and in Chronic Pancreatitis

Investigation of Exocrine Pancreatic Function by Continuous Infusion of Caerulein and Secretin in Normal Subjects and in Chronic Pancreatitis

Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.

Effect of CCK-Octapeptide and Secretin on Amylase Secretion in Isolated Rat Pancreatic Acinar Cells

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