Effect of Screening for Red Cell Antibodies, Other Than Anti-D, to Detect Hemolytic Disease of the Fetus and Newborn: A Population Study in The Netherlands

Koelewijn, Joke M.; Schoot, Vrijkotte C. E. van der; Bonsel, G.J.; Haas, Masja de

doi:10.1097/01.ogx.0000325907.36552.f4

Cited by 77 publications

(178 citation statements)

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“…A wide variation from 0.9 to 7.1 % can be seen regarding alloimmunization rates in the D antigen-negative group [8,10,17]. The rate of alloimmunization in the D antigen-negative group is higher in present study.…”

Section: Discussionmentioning

confidence: 42%

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Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Sidhu

Bala

Akhtar

et al. 2015

Indian J Hematol Blood Transfus

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Screening and detection of clinically significant antibodies among antenatal women plays an important role in transfusion safety and preventing hemolytic disease of fetus and newborn. Routine screening of antenatal women for antibodies is not done in all blood centres of our country and so immunization rates are not known in pregnant women. We studied the prevalence of alloantibodies and titration of Anti D among antenatal multiparous women in Jammu region. In present prospective study, 750 antenatal multiparous women attending antenatal clinics were typed for ABO and D antigens. Alloantibody screening was done, if positive, specificity of alloantibody was ascertained by using commercially available red cell panel by tube method. Rate of alloimmunization was correlated with Rh D status, gravida, previous transfusion history and bad obstetric history. Titration of alloantibody D was done in first and third trimester of pregnancy. In present study most common blood group detected was B positive (38.4 %). Rh D negative cases constituted 7.6 % of total cases. Rate of alloimmunization was 2 %. A significant correlation was seen between Rh D-negative and alloimmunization (21 % in D-negative and 0.45 % in D-positive). There is significant increasing degree of alloimmunization with increase in Gravida. Alloimmunization in females with bad obstetric history was high

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Section: Discussionmentioning

confidence: 42%

“…Alloimmunization rates in antenatal females ranged from 0.4 to 2.71 % [8][9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Sidhu

Bala

Akhtar

et al. 2015

Indian J Hematol Blood Transfus

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“…The most common antibodies were anti-E, followed by anti-K and anti-C. Severe HDN resulting from immunization to antigens other than D and requiring intrauterine or postnatal transfusions developed in 21 of 567 (3.7 %) of the pregnancies that were at risk; the antibodies were anti-K in 11.6 %; anti-c in 8.5 %; anti-E in 1.1 %; and Rh antibodies other than anti-C, anti-D, or anti-E in 3.8 % [7]. Serum bilirubin direct 11.9 1.5…”

Section: Discussionmentioning

confidence: 99%

Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report

Sheeladevi

Satish

Manjunath

et al. 2012

Indian J Hematol Blood Transfus

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The Rhesus (Rh) blood group is one of the most complex blood groups known in humans. It has remained of primary importance in obstetrics, being the main cause of hemolytic disease of the newborn (HDN). Anti-D causes the most severe form of HDN. Other Rh allo antibodies that are capable of causing severe HDN include anti-c, which clinically is the most important Rh antigen after the D antigen. We report a case of hemolytic disease of the newborn due to Rh anti-c in an infant of an Rh positive mother.

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“…In particular, anti-c (anti-RH4) in the Rh system and anti-K (anti-KEL1) in the Kell system are the next most common causes of HDFN, while Rh antigens C (RH2) and E (RH5) only occasionally result in severe HDFN. 24,25 Analysis of fetal cff DNA obtained from maternal blood represents a noninvasive approach for determining whether the fetus is a carrier of the corresponding antigen. In this approach, the DNA of the fetus is detected in the venous blood of the mother.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of noninvasive polymerase chain reaction testing for the determination of fetal rhesus C, c and E status in early pregnancy

Gutensohn¹,

Müller

Thomann

et al. 2010

BJOG

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Objective The aim of the study was to determine the sensitivity, specificity and accuracy of noninvasive tests for the fetal rhesus CcEc (RHCE) alleles C, c and E in early pregnancy.Design A prospective clinical trial was carried out to evaluate diagnostic accuracy.Setting Women were recruited at four centres specialising in prenatal diagnosis. Peripheral blood and amniotic fluid samples were obtained and sent to a single laboratory for analysis.Sample A total of 233 tests (46 for C, 87 for c and 100 for E) were performed on 181 specimens obtained from pregnant women at weeks 12 to 28 (median week 16) of gestation.Methods Following automated extraction of fetal DNA from maternal plasma, two different real-time polymerase chain reaction (PCR) protocols were used for the detection of the C, c and E alleles of RHCE. The results of the PCR were compared with genotyping results for the amniotic fluid.Main outcome measures Failure rate, sensitivity, specificity and accuracy were the main outcome measures.Results Unequivocal results were obtained for all specimens. With the first PCR protocol, the sensitivity was 100% for C, 38% for c and 59% for E. In contrast, with the second protocol, the sensitivity for C, c and E was 100%. The specificity for all assays was found to be between 99% and 100%.Conclusions A highly accurate protocol has been identified for the detection of fetal RHCE alleles in maternal plasma in early pregnancy. This noninvasive approach can be considered as a useful test in the management of pregnancies with anti-c, anti-E or anti-C alloimmunisation.

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Effect of Screening for Red Cell Antibodies, Other Than Anti-D, to Detect Hemolytic Disease of the Fetus and Newborn: A Population Study in The Netherlands

Cited by 77 publications

References 0 publications

Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Prevalence, Specificity and Titration of Red Cell Alloantibodies in Multiparous Antenatal Females at a Tertiary Care Centre from North India

Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report

Diagnostic accuracy of noninvasive polymerase chain reaction testing for the determination of fetal rhesus C, c and E status in early pregnancy

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