Effect of scorpion Leiurus quinquestriatus (H&amp;E) venom on the clinical chemistry parameters of the rat

Omran, Mohamed A.; Abdel‐Rahman, Mohamed S.

doi:10.1016/0378-4274(92)90068-u

Cited by 22 publications

(15 citation statements)

References 38 publications

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“…Such manifestations reveal that scorpion envenomation causes an autonomic storm (6,7,9). In the present study, significant hyperglycemia was noticed after H. lepturus venom administration, which is quite compatible to the results of other studies (2,8,12,19).…”

Section: Discussionsupporting

confidence: 93%

Clinical and biochemical manifestation produced by scorpion (Hemiscorpius lepturus) venom in experimental animals

A.¹,

Zolfagharian²,

Hedayat³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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Several studies have been published about the clinical and biochemical manifestations produced by the venom of scorpions of the Buthidae family, but very few reports have indicated the manifestations induced by the venom of the Scorpionidae family. Hemiscorpius lepturus is an important scorpion species present in the south and southwestern part of Iran, causing morbidity and mortality in children and adults. For the present study, H. lepturus venom was extracted by electric shock and subcutaneously injected (6.3mg/kg) into a group of six rabbits. Blood collection was carried out before and three hours after venom injection for determination of osmotic fragility and levels of blood sugar, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and alkaline phosphatase (ALP). In vitro studies were also carried out to verify the osmotic fragility of red blood cells (RBCs) exposed to venom concentrations ranging from 0-90µg/2ml blood. Results showed the extreme effect of this venom on the lysis of RBCs both in vitro and in vivo. Venom injection caused significant (p>0.001) increase in ALT, AST, LDH and blood sugar levels. There was also an increase in CPK, and ALP levels after venom injection; however, it was not statistically significant. All animals died four hours after having received the venom. The current study revealed that the neurological effect of H. lepturus venom is similar to that of scorpions of the Buthidae family. However, they differ in RBCs lysis, which was highly significant when induced by H. lepturus venom, probably due to the presence of a type of phospholipase in this venom. Further studies are needed to provide a clearer view of the mechanism of action of H. lepturus venom

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Section: Discussionsupporting

confidence: 93%

Clinical and biochemical manifestation produced by scorpion (Hemiscorpius lepturus) venom in experimental animals

A.¹,

Zolfagharian²,

Hedayat³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Thus, in scorpion envenomation lactate is produced but not utilized, leading to lactate acidosis which inhibits the secretory mechanism of uric acid, thereby increasing the serum uric acid level (Radha Krishna Murthy et al, 2003). In contrast to our ¼ndings, serum uric acid level has been reported to decrease after Leiurus quinquestriatus and Palamneus gravimanus envenomation (Omran and Abdel-Rahman, 2002;More et al, 2004). Low cholesterol is a symptom of depression and hyperthyroidism after scorpion sting (Radha Krishna Murthy and Zare, 1998).…”

Section: Discussioncontrasting

confidence: 59%

Biochemical and enzymatic changes after black scorpion Heterometrus fastigiousus Couzijn envenomation in experimental albino mice

Chaubey¹,

Upadhyay

2008

J of Applied Toxicology

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The toxic effects of Asian black scorpion Heterometrus fastigiousus (Family, Scorpionidae) venom were determined in albino mice (NIH strain). Venom was isolated and fractioned by Sepharose CL-6B column chromatography. The toxicity of fractioned venom was determined in albino mice by subcutaneous envenomation. The LD(50) of venom was found to be 15 mg kg(-1) body weight and range of molecular weight of venom proteins responsible for toxicity was found from 9.5-63 kDs. The effects of fractioned venom on different biochemical and enzymatic parameters in blood serum and gastrocnemius muscle tissue of albino mice were determined after experimental envenomation. An increase in serum levels of glucose, free amino acids, uric acid, pyruvic acid and total protein was observed while a decrease in the cholesterol level in serum was observed after 4 h of envenomation. Increase in alkaline phosphatase (ALP), acid phosphatase (ACP), lactic dehydrogenase (LDH) and glutamate-pyruvate transaminase (GPT) enzyme activity in serum was observed. Glycogen content in liver, atria, ventricle, rectus abdominus and gastrocnemius muscle was decreased after experimental envenomation. Activity of ALP, ACP, LDH, GPT, AChE and Na+K+ATPase enzymes in gastrocnemius muscle tissue of envenomed albino mice was studied. Inhibition in ALP, AChE and Na+K+ATPase enzyme activity and increase in ACP, LDH and GPT enzyme activity was observed in gastrocnemius muscle after scorpion envenomation. In vitro studies with AChE and Na+K+ATPase enzymes indicated that enzymatic activity of AChE was inhibited competitively by fractioned venom in gastrocnemius muscle.

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“…Many studies have emphasized that blood glucose levels increase after envenomation resulting in hyperglycemia in animal models (10,16,22,(27)(28)(29)(30)(31)49) and patients (2,11,12,47). In the present study, hyperglycemia was seen after A. crassicauda venom administration.…”

Section: Discussionsupporting

confidence: 55%

“…Some researchers have reported that ALT and AST activities in the serum change during scorpion envenomation (22,26,31,37,49). Similarly, ALT and AST activities were observed following A. crassicauda venom injection.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom on rat metabolism

Özkan¹,

Bakır²,

Adiguzel³

2008

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:Scorpions are venomous arthropods of the Arachnida class and are considered relatives of spiders, ticks and mites. There is not any study about the biochemical effects of Androctonus crassicauda (Olivier, 1807) venom. Therefore, in the present study, we aimed at evaluating the toxicity of the venom from A. crassicauda, which is responsible for a number of deaths of infants, children and adults in tropical and subtropical countries. For this purpose, rats (n=35) were divided into seven groups of five animals each; venom solutions (250µg/kg) were subcutaneously injected into rats; blood samples were taken from each animal at various times; and serum biochemical parameters were measured (levels of total proteins, total bilirubin, albumin, globulin, urea, creatinine, uric acid, glucose, cholesterol, triglycerides, sodium, chlorine, potassium and calcium, and the activity of the enzymes alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase). Serum levels of glucose, cholesterol, aspartate aminotransferase, alanine aminotransferase and uric acid increased in envenomed animals, compared to controls. There was a statistically positive correlation between Na + and Cl -ions.

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Effect of scorpion Leiurus quinquestriatus (H&E) venom on the clinical chemistry parameters of the rat

Cited by 22 publications

References 38 publications

Clinical and biochemical manifestation produced by scorpion (Hemiscorpius lepturus) venom in experimental animals

Clinical and biochemical manifestation produced by scorpion (Hemiscorpius lepturus) venom in experimental animals

Biochemical and enzymatic changes after black scorpion Heterometrus fastigiousus Couzijn envenomation in experimental albino mice

Effects of Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae) venom on rat metabolism

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