Effect of Schistosoma Mansoni Infection on Pentobarbital-Induced Sleeping-Time in Mice *

Biodistribution Study of the Anaesthetic Sodium Phenobarbital Labelled with Technetium-99m in Swiss Mice Infected with Schistosoma mansoni Sambon, 1907

“…The anatomical, histological and physiopathlogical alterations due to the schistosomiasis infection could justify the decreasing of the radioactivity uptake in liver and spleen (Coelho et al 1977). In the S. mansoni infected animals there is a severe diminishement of the hepatic function and its capacity to metabolize drugs is reduced due to the microsomial enzyme activities are altered (Cha et al 1980).…”