Effect of scaling and root planing on serum interleukin-10 levels and glycemic control in chronic periodontitis and type 2 diabetes mellitus

Acharya, Anirudh B.; Thakur, Srinath; Muddapur, M.V.

doi:10.4103/0972-124x.148644

Cited by 25 publications

(27 citation statements)

References 34 publications

(40 reference statements)

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“…According to Novella et al31 Post-menopausal women may have augmented circulating markers like TNF-α, which increases inflammation and increasing artery responsiveness to stimulate vasoconstriction. Studies demonstrated that NSPT reduces inflammation and improves periodontal status 32. Therefore it can be assumed that overall inflammatory markers also reduce after NSPT 171819.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Salivary Neopterin Levels and Its Effects to Periodontal Therapy in Pre- and Post-Menopausal Women

et al. 2017

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ObjectivesNeopterin is a valuable diagnostic biomarker, which is elevated in inflammatory conditions like periodontitis, that is characterized by destruction of the supporting structures of the teeth. Among the biomarkers, neopterin occurs in body fluids, and acts as a diagnostic marker for present and future disease activity.MethodsThirty female subjects with chronic periodontitis, mean age 50 years (40-60 years) were included in this study. Depending upon their menstrual history, subjects were categorized into two groups of fifteen each. Group I 15 pre-menopausal women, and Group II 15 post-menopausal women. Saliva was collected, and neopterin levels were assessed by enzyme-linked immunosorbent assay in both the groups, at base line and after three months of nonsurgical periodontal therapy (NSPT). Periodontal parameters like pocket probing depth (PD) and Russell's periodontal disease index (PDI) were assessed before treatment as well as after three months of scaling and root planning.ResultsIntra group analysis showed significant markdown in the mean values of all the parameters from baseline to three months (P < 0.001), for all patients. The intergroup comparison, from baseline to 3 months also showed no significant change in PD and PDI values, but there was a statistically significant difference in the salivary neopterin levels (P = 0.04).ConclusionsNeopterin levels were found to be reduced in three months after NSPT in both the groups, suggesting that the NSPT is the gold standard therapy, and also that neopterin levels in saliva can be used as an indicator to identify periodontal inflammation and destruction.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Salivary Neopterin Levels and Its Effects to Periodontal Therapy in Pre- and Post-Menopausal Women

et al. 2017

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“…DM2 individuals, with poor glycemic control, are more likely to develop severe and generalized periodontitis . The prevalence of DM2 and CP is high and the association of these two conditions, one influencing the other, is recognized and documented …”

Section: Introductionmentioning

confidence: 99%

“…A severe chronic systemic inflammation in DM2 individuals may be induced or perpetuated by CP, resulting in increased insulin resistance and ineffective glycemic control. The reduction of periodontal inflammation can restore insulin sensitivity and, consequently, better metabolic control . In this context, the host innate immunity components, such as antimicrobial peptides (defensins), are of great importance, playing a crucial role in the defense against pathogens …”

Section: Introductionmentioning

confidence: 99%

“…5 The prevalence of DM2 and CP is high and the association of these two conditions, one influencing the other, is recognized and documented. [5][6][7][8] A severe chronic systemic inflammation in DM2 individuals may be induced or perpetuated by CP, resulting in increased insulin resistance and ineffective glycemic control. The reduction of periodontal inflammation can restore insulin sensitivity and, consequently, better metabolic control.…”

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confidence: 99%

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Evaluation of DEFB1 polymorphisms in individuals with chronic periodontitis and diabetes mellitus type 2 in a population of northeastern Brazil

Dias

Pinho

Almeida

et al. 2018

Special Care in Dentistry

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“…8 Several researchers have indicated that improved oral health leads to improved diabetes control. 9–11 …”

Section: Introductionmentioning

confidence: 99%

Preventive dental care in older adults with diabetes

Wiener¹,

Shen²,

Sambamoorthi³

et al. 2016

The Journal of the American Dental Association

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Background The association between poor oral health and diabetes is well documented. Therefore, preventive oral health is strongly indicated for individuals with diabetes. The purposes of this study were 1) to determine if there were a difference in preventive dental care utilization among older adults with diabetes from 2002 and 2011, and 2) to compare preventive dental care utilization of older adults with and without diabetes from 2002 and 2011. Methods The data were from the Medicare Current Beneficiary Survey. The sample included older, fee-for-service Medicare beneficiaries (ages 65 years and above). The key outcome was self-reported preventive dental care. In 2002, there were 8,725 participants; in 2011, there were 7,425 participants. Chi square and logistic regressions were conducted. Results In 2002, 28.8 % of participants with diabetes had preventive dental care. In 2011, this percentage increased to 36.0%. Similar results were seen among individuals without diabetes (42.9% in 2002 and 45.5% in 2011). The increase in preventive dental care was statistically significant for individuals with and without diabetes. The participants with diabetes, as compared with participants without diabetes, remained statistically less likely to have preventive dental care in adjusted logistic regression analysis with and without considering the interaction between observation year and diabetes (adjusted odds ratios= 0.73, and 0.86, respectively). Conclusion While the increase in preventive dental care is welcoming, older adults with diabetes continue to have significant preventive dental care need. Practical Implication Additional efforts are needed to encourage individuals with diabetes to obtain preventive dental care.

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Effect of scaling and root planing on serum interleukin-10 levels and glycemic control in chronic periodontitis and type 2 diabetes mellitus

Cited by 25 publications

References 34 publications

Comparative Evaluation of Salivary Neopterin Levels and Its Effects to Periodontal Therapy in Pre- and Post-Menopausal Women

Comparative Evaluation of Salivary Neopterin Levels and Its Effects to Periodontal Therapy in Pre- and Post-Menopausal Women

Evaluation of DEFB1 polymorphisms in individuals with chronic periodontitis and diabetes mellitus type 2 in a population of northeastern Brazil

Preventive dental care in older adults with diabetes

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