Effect of scaling &amp; root planing on the activity of ALP in GCF &amp; serum of patients with gingivitis, chronic and aggressive periodontitis: A comparative study

Singh, Nishi; Chandel, Siddhartha; Singh, Harpreet; Agrawal, Amiya; Savitha, A N

doi:10.1016/j.jobcr.2017.03.006

Cited by 15 publications

(13 citation statements)

References 15 publications

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“…This finding is in agreement with a study indicated that ALP levels in gingival crevicular fluid increased significantly during the active phase of disease of chronic periodontitis followed by a statistically significant reduction after phase I therapy. 34 The gain of improvement of ALP was more in group A, according to a study conducted by Kushiyama and Shimazaki. 35 Green tea has an inhibitory effect on the growth and cellular adherence of bacterial pathogens and their production of virulence factors.…”

Section: Discussionmentioning

confidence: 90%

Efficacy of green tea mouth wash as an adjunct to non-surgical periodontal treatment in patients with chronic periodontitis

Mustafa

Baban

2019

EDJ

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Background and objectives: Periodontal disease is the most common disease associated with microbial infection with the destruction of supporting structures. This study was carried out to evaluate the effectiveness of green tea as a mouthwash in the management of chronic periodontitis in comparison to chlorhexidine mouthwash. Patients and methods: A randomized controlled trial on 45 healthy humans with mild to moderate localized chronic periodontitis. They were randomly assigned into 3 equal groups (15 patients each), and they all received scaling and root surface debridement treatments. Group A used prepared green tea 5% as mouth wash for 2 weeks, group B used chlorhexidine mouthwash 0.12% for 2 weeks and group C did not use any mouth wash. Intra-oral clinical examination and blood samples collection were done for all patients for estimating the biochemical parameters C-reactive protein, alkaline phosphatase, Malondialdehyde at baseline and 30 days after periodontal therapy. For statistical analysis, SPSS program was used. Results: The study groups showed significant reduction in clinical periodontal parameters and inflammatory markers after 30 days of periodontal therapy (P<0.001). A significant difference was seen between group A and group B in relation to clinical periodontal parameters and inflammatory markers after periodontal therapy P<0.05, while the difference between group B and group C was non-significant in relation to gingival index, clinical attachment level, C-reactive protein, alkaline phosphatase, and Malondialdehyde. Conclusion: Green tea as a mouthwash could be an appropriate and effective choice as an adjunctive measure in the treatment of chronic periodontitis.

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Section: Discussionmentioning

confidence: 90%

Efficacy of green tea mouth wash as an adjunct to non-surgical periodontal treatment in patients with chronic periodontitis

Mustafa

Baban

2019

EDJ

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“…This is probably due to an impaired PMN function in patients with AP. In line with the intensity of the pathological process in periodontal tissue, the release of ALP also correlated.In patients with chronic periodontitis, the GI values and the depth of the periodontal pocket were statistically correlated with the level of ALP in the saliva [10] and gingival fluid [25]. The authors believe that the ALP enzyme can be a predictor of progression of periodontal diseases.…”

Section: Discussionmentioning

confidence: 99%

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

et al. 2021

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Introduction/Objective. Aggressive periodontitis (AP) is a progressive disease that leads damage to periodontal tissues. The aim of the study was the analysis of intracellular enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) and electrolytes in the saliva of patients with AP and their correlation with clinical parameters before and after the therapy. Methods. The study included 30 patients with AP (experimental group) and 35 patients with healthy parodontium (control group). Intracellular enzymes and electrolytes were analyzed in an unstimulated saliva of subjects with AP, before and after the therapy and in saliva of the control group. The analysis of biochemical markers was carried out using kinetic methods with commercial reagents. Results. Concentrations of the biochemical markers AST (28.18 ? 25.16), ALT (5.48 ? 5.14), ALP (31.13 ? 37.79), ACP (17.53 ? 14.77), calcium (2.80 ? 1.97), phosphate (4.43 ? 1.92) in the saliva of subjects of the experimental group were statistically significantly higher in relation to the control group (p = 0.000; p = 0.001). Significant correlation was found between AST values, debris index (? = -0.444; p = 0.026) and calculus index (? = -0.513; p = 0.009), and between the plaque index and ALP level in the saliva after therapy (p = 0.020). Conclusion. The investigation will contribute to a better understanding and standardization of biomarkers in the saliva that mayhelp in diagnosing the AP and evaluation of the applied therapy.

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“…[14][15][16][17][18][19][20][21][22][23][24] Gibert (2003) 25 This study showed a positive and statistically significant correlation with ALP saliva level and not significant relation with serum ALP levels after phase I therapy which is in accordance to a study by Singh (2017). 26 Jeyasree (2018) found the difference in salivary and serum ALP levels from baseline (79.55 ± 6.40 and 97.62 ± 4.17)…”

Section: Levels Of Saliva Alp Change Was Positively Correlated Tomentioning

confidence: 99%

Alkaline Phosphatase Levels Before and After Nonsurgical Periodontal Therapy

Pradhan¹,

Koirala²

2019

J Nepal Soc Perio Oral Implantology

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Introduction: Chronic periodontitis is a multifactorial disease resulting in the inflammation and destruction of the supporting structures. Early detection of periodontal changes, prognosis and efficacy of treatment have been monitored by Alkaline Phosphatase Levels (ALP) levels. Objective: This study was carried out to determine level of ALP in saliva and serum before and after periodontal therapy. Methods: This pretest posttest study included 22 patients with generalised chronic periodontitis (GCP). The patients received nonsurgical periodontal therapy (NSPT). Saliva and serum levels of ALP were measured at baseline and after two months of periodontal therapy. Results: Twenty-two patients of mean age 44 years were analysed. Participants had significantly better periodontal parameters after two months. Salivary ALP levels, which were high at baseline, decreased after periodontal treatment. A significant positive correlation (0.0001) was found between the salivary levels of ALP and periodontal inflammatory conditions. Gingival index was found directly proportional with salivary ALP level but not with serum ALP. Conclusion: Periodontal therapy lowered the levels of ALP saliva in GCP patients with high ALP levels. Biochemical analysis of enzymes found in saliva may help in patients’ evaluation to determine the control and progression of periodontal destruction and aid in a correct diagnosis, prognosis and, consequently, better treatment.

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Effect of scaling & root planing on the activity of ALP in GCF & serum of patients with gingivitis, chronic and aggressive periodontitis: A comparative study

Cited by 15 publications

References 15 publications

Efficacy of green tea mouth wash as an adjunct to non-surgical periodontal treatment in patients with chronic periodontitis

Efficacy of green tea mouth wash as an adjunct to non-surgical periodontal treatment in patients with chronic periodontitis

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

Alkaline Phosphatase Levels Before and After Nonsurgical Periodontal Therapy

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