Alkaline Phosphatase Levels Before and After Nonsurgical Periodontal Therapy

Abstract

Introduction: Chronic periodontitis is a multifactorial disease resulting in the inflammation and destruction of the supporting structures. Early detection of periodontal changes, prognosis and efficacy of treatment have been monitored by Alkaline Phosphatase Levels (ALP) levels.
 Objective: This study was carried out to determine level of ALP in saliva and serum before and after periodontal therapy.
 Methods: This pretest posttest study included 22 patients with generalised chronic periodontitis (GCP). The patients received nonsurgical periodontal therapy (NSPT). Saliva and serum levels of ALP were measured at baseline and after two months of periodontal therapy.
 Results: Twenty-two patients of mean age 44 years were analysed. Participants had significantly better periodontal parameters after two months. Salivary ALP levels, which were high at baseline, decreased after periodontal treatment. A significant positive correlation (0.0001) was found between the salivary levels of ALP and periodontal inflammatory conditions. Gingival index was found directly proportional with salivary ALP level but not with serum ALP.
 Conclusion: Periodontal therapy lowered the levels of ALP saliva in GCP patients with high ALP levels. Biochemical analysis of enzymes found in saliva may help in patients’ evaluation to determine the control and progression of periodontal destruction and aid in a correct diagnosis, prognosis and, consequently, better treatment.

Salivary Alkaline Phosphatase Level in People with Healthy Periodontium and Generalised Chronic Periodontitis

“…In addition interventional studies are also necessary to examine the potential benefits of periodontal treatment. 26 If the consequences of treatment had been included in the study, it would have been more effective. Further longitudinal studies can be recommended.…”

Vitamin D, Calcium, Alkaline Phosphatase, and Parathyroid Hormone in Patients with and without Chronic Periodontitis

“…Pradhan et al found significantly increased salivary as well as serum ALP levels in generalised chronic periodontitis patients and after two months of non-surgical periodontal therapy significant reduction was seen in salivary ALP levels; however, no significant reduction was seen in serum ALP levels after two months 29. This might have occurred as serum ALP level depends on function of other organs as well such as bone, kidney, liver, etc.…”